Oligonucleotide/atom fine nanocluster compound capable of efficiently penetrating through blood brain barrier and preparation method and application thereof

A technology of oligonucleotide and nanocluster, which is applied in the field of oligonucleotide/atom fine nanocluster complex and its preparation, can solve the problems of lack of efficient materials for crossing the blood-brain barrier, and achieve good biological learning effect, improving crossing efficiency, and efficient crossing effect
CN111991561APending Publication Date: 2020-11-27SHANGHAI ADVANCED RES INST CHINESE ACADEMY OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI ADVANCED RES INST CHINESE ACADEMY OF SCI
Publication Date
2020-11-27

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Abstract

The invention provides an oligonucleotide / atom fine nanocluster compound capable of efficiently penetrating through a blood brain barrier. The oligonucleotide / atom fine nanocluster compound is composed of oligonucleotide and hydrophobic atom fine nanocluster, and is viroid particles which has a hydrophilic oligonucleotide shell and has a hydrophobic atom fine nanocluster core, wherein the oligonucleotide is an oligonucleotide single chain formed by arranging at least one of adenine, guanine, cytosine and thymine according to any combination, and the hydrophobic atom fine nanocluster is a cluster of hydrophobic metal atoms with an atom fine structure. The oligonucleotide / atom fine nanocluster compound provided by the invention provides an effective drug carrier for brain near-infrared imaging and imaging and treatment of brain tumors or neurodegenerative diseases.
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Description

technical field

[0001] The invention belongs to the field of nano-biological materials, and in particular relates to an oligonucleotide / atom fine nano-cluster complex efficiently passing through the blood-brain barrier, a preparation method and application thereof. Background technique

[0002] The Blood-Brain Barrier (BBB) ​​is an international problem in the treatment of brain diseases. Because of its existence, 100% of macromolecular drugs and more than 98% of small molecule drugs cannot pass through and reach brain tissue, which greatly limits the efficacy of drugs on brain diseases. Therefore, the invention of a biomaterial or drug carrier that can effectively penetrate the blood-brain barrier has been highly anticipated.

[0003] The blood-brain barrier is a special structure mainly composed of brain capillary endothelial cells, sticky ends of astrocytes and tight junctions of pericytes. Under normal physiological conditions, the blood-brain barrier only allows gases...

Claims

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