A kind of iron/shikonin nanocomposite, preparation method of its supramolecular self-assembly and application of the nanocomposite

A nanocomposite, shikonin technology, applied in the field of iron/shikonin nanocomposites, can solve the problems of unsatisfactory therapeutic properties of nanomedicine, and achieve uniform and adjustable product size, good biocompatibility, The effect of improving bioavailability

Active Publication Date: 2022-03-11
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

On the basis of enhanced permeability and retention (EPR), nano-drugs have many advantages such as increasing the solubility of hydrophobic drugs. However, during the transport of shikonin-loaded nano-materials to the tumor area, the problem of drug loss and release remains to be solved. Furthermore, designing nanomaterials that can trigger drug release at the lesion site is also a major challenge; in addition, the therapeutic properties of these nanomedicines are not satisfactory, prompting researchers to incorporate more therapeutic methods into nanoformulations , to enhance its anticancer effect

Method used

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  • A kind of iron/shikonin nanocomposite, preparation method of its supramolecular self-assembly and application of the nanocomposite
  • A kind of iron/shikonin nanocomposite, preparation method of its supramolecular self-assembly and application of the nanocomposite
  • A kind of iron/shikonin nanocomposite, preparation method of its supramolecular self-assembly and application of the nanocomposite

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Embodiment 1

[0029] Dissolve ferric chloride hexahydrate in water to prepare an aqueous ferric chloride solution with a concentration of 100 mg / mL; dissolve shikonin monomer in ethanol to prepare a shikonin ethanol solution with a concentration of 5 mg / mL. Under stirring at room temperature, 1 mL of ferric chloride aqueous solution and 5 mL of shikonin ethanol solution were successively added into 40.75 mL of water. After stirring at room temperature for 1 hour, centrifuge at 15,000 rpm for 15 minutes and centrifuge 3 times in total to obtain an iron / shikonin nanocomposite solution with an average size of 30 nm, which can finally dissolve the iron / shikonin nanocomposite To obtain a nanocomposite solution with a concentration of 100 mg / mL in water.

Embodiment 2

[0031] Dissolve ferric chloride hexahydrate in water to prepare an aqueous ferric chloride solution with a concentration of 100 mg / mL, and dissolve shikonin monomer in ethanol to prepare a shikonin ethanol solution with a concentration of 5 mg / mL. Under stirring at room temperature, 500 μL of ferric chloride aqueous solution and 5 mL of shikonin ethanol solution were sequentially added to 41.25 mL of water. After stirring at room temperature for 1 hour, centrifuge at 15,000 rpm for 15 minutes and centrifuge 3 times in total to obtain an iron / shikonin nanocomposite solution with an average size of 50 nm.

Embodiment 3

[0033] Dissolve ferric chloride hexahydrate in water to prepare an aqueous ferric chloride solution with a concentration of 100 mg / mL, and dissolve shikonin monomer in ethanol to prepare a shikonin ethanol solution with a concentration of 5 mg / mL. Under stirring at room temperature, 100 μL of ferric chloride aqueous solution and 5 mL of shikonin ethanol solution were sequentially added to 41.65 mL of water. After stirring at room temperature for 1 hour, centrifuge at 15,000 rpm for 15 minutes and centrifuge 3 times in total to obtain an iron / shikonin nanocomposite solution with an average size of 70 nm.

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Abstract

An iron / shikonin nanocomposite, its supramolecular self-assembly preparation method and application of the nanocomposite belong to the technical field of functional materials. The complex is composed of shikonin monomer and ferric ion; shikonin monomer coordinates with ferric ion, and the hydroxyl group and carbonyl group in shikonin monomer coordinate with ferric ion to form a complex, and then Glutathione-responsive nanocomplexes are assembled via π‑π stacking and hydrophobic interactions. It is obtained by sequentially adding a ferric iron salt solution and an organic solvent solution of shikonin monomer to water under stirring at room temperature; after continuing to stir at room temperature, it is obtained by centrifugal purification and water washing. The invention has mild reaction conditions, uniform and controllable particle size of the complex, can significantly increase the solubility of shikonin in water, and improve bioavailability; it can be dismantled responsively in the tumor cell environment, releasing iron and shikonin, effectively It is used in the field of biomedicine to prepare drugs for treating cancer.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and specifically relates to an iron / shikonin nanocomposite, a preparation method for its supramolecular self-assembly and an application of the nanocomposite. The preparation method can effectively increase the solubility of shikonin in water, and the nanocomposite can better play the role of chemokinetic therapy and chemotherapy in cancer treatment, and can be used to prepare medicines for treating cancer. Background technique [0002] Shikonin is the main bioactive component extracted from the root of comfrey, and it is a class of polyphenolic compounds. In cancer treatment, it has received widespread attention. Many studies have shown that shikonin can play an anti-cancer role by inhibiting cancer cell proliferation, inducing apoptosis, inhibiting cancer cell migration and invasion; it can also activate anti-tumor immunity through various molecular mechanisms. However, shikonin ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61K47/52A61P35/00B82Y5/00B82Y40/00
CPCA61K31/122A61K47/52A61P35/00B82Y5/00B82Y40/00A61K47/6929A61K9/143
Inventor 张皓封文洁刘轶张乐宁石万瑞
Owner JILIN UNIV
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