Check patentability & draft patents in minutes with Patsnap Eureka AI!

Rapidly-formed injectable multifunctional hydrogel, preparation method and application thereof

A hydrogel and multifunctional technology, which is applied in the field of rapid prototyping injectable multifunctional hydrogel and its preparation, can solve the problems of uneven gel formation, long gel formation time, etc. Fast, good biocompatibility results

Active Publication Date: 2020-12-11
GUANGDONG PROV MEDICAL INSTR INST
View PDF6 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, the first purpose of the present invention is to propose a preparation method of a rapidly prototyping injectable multifunctional hydrogel (hereinafter referred to as hydrogel), which can improve the problems of uneven gelation and long gelation time, and quickly Produces uniform, transparent hydrogels

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Rapidly-formed injectable multifunctional hydrogel, preparation method and application thereof
  • Rapidly-formed injectable multifunctional hydrogel, preparation method and application thereof
  • Rapidly-formed injectable multifunctional hydrogel, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A kind of hydrogel, its preparation method comprises the steps:

[0031] (1) Weigh a certain quality of sodium alginate, make it into a sodium alginate solution with a mass concentration of 1.5% with pure water, then add EDC to stir the solution for 4 hours to complete the carboxylation treatment, then add 0.1% NaCl to it and stir Evenly, a solution was obtained.

[0032] (2) Take a certain mass of chitosan quaternary ammonium salt with a degree of substitution of 95%, make it into a solution with a mass concentration of 3% with pure water, then add 0.1% NaCl therein and stir evenly to obtain b solution.

[0033] (3) CaCl with a molar concentration of 0.1% 2 The solution is ready for use.

[0034] (4) Mix solution a and solution b at a volume ratio of 1:1 to form a hydrogel.

[0035] (5) soak the hydrogel in 0.1% CaCl 2 Injectable hydrogel of certain strength can be obtained in the solution.

[0036] Wherein, the photo and SEM figure of the hydrogel formed in step ...

Embodiment 2

[0040] A kind of hydrogel, its preparation method comprises the steps:

[0041] (1) Weigh a certain quality of sodium alginate, make it into a sodium alginate solution with a mass concentration of 2% with pure water, then add EDC to stir the solution for 4 hours to complete the carboxylation treatment, then add 0.1% NaCl to it and stir Evenly, a solution was obtained.

[0042] (2) Take a certain amount of chitosan, make it into a chitosan solution with a mass concentration of 2% with 0.1% acetic acid solution, then add 0.1% NaCl and 0.1% molar concentration of CaCO 3 solution (from CaCO 3 Soluble in acidic system to get Ca 2+ solution) and stirred evenly to obtain b solution.

[0043] (3) Mix solution a and solution b uniformly at a volume ratio of 2:1 to form an injectable hydrogel of a certain strength.

[0044] Similar to Example 1, the hydrogel prepared in this example is transparent, has good molding effect and uniform structure. After testing, the hydrogel can norma...

Embodiment 3

[0046] A kind of hydrogel, its preparation method comprises the steps:

[0047] (1) Weigh a certain amount of sodium carboxymethyl cellulose, make it into a sodium alginate solution with a mass concentration of 3% with pure water, then add EDC to stir the solution for 4 hours to complete the carboxylation treatment, and then add 0.1% NaCl was stirred evenly to obtain a solution.

[0048] (2) Take a certain mass of chitosan quaternary ammonium salt with a degree of substitution of 90%, make it into a solution with a mass concentration of 3% with pure water, then add 0.1% NaCl therein and stir evenly to obtain b solution.

[0049] (3) CaCl with a molar concentration of 0.1% 2 The solution is ready for use.

[0050] (4) Mix solution a and solution b at a volume of 1:1 to form a hydrogel, soak the gel in 0.1% CaCl 2 Injectable hydrogel of certain strength can be obtained in the solution.

[0051] Similar to Example 1, the hydrogel prepared in this example is transparent and unif...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a rapidly-formed injectable multifunctional hydrogel, a preparation method and application thereof. The preparation method of the hydrogel comprises the following steps: (1) adding a carboxyl activator and a charge shielding agent into a polyanion solution to obtain a solution a; (2) adding a charge shielding agent into a polycation solution to obtain a solution b; and (3)mixing the solution a and the solution b to obtain the hydrogel. According to the invention, the charge shielding agent is added into the polyanion solution and the polycation solution to avoid agglomeration of polyanions and polycations, after the solution a and the solution b are mixed, uniform and transparent hydrogel is immediately formed under the electrostatic action of non-covalent bonds between polyanions and cations and the action of hydrogen bonds between molecules in the system, and the gel is immediately formed after mixing, so that the gel forming time is short, and static precipitation is not needed.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, and in particular relates to a rapidly prototyping injectable multifunctional hydrogel and a preparation method and application thereof. Background technique [0002] Hydrogels are a class of polymers with a cross-linked network structure that can absorb and retain a large amount of water, and their applications in the biomedical field are gradually expanding. Injectable hydrogel is a new type of hydrogel that can be implanted into the body by injection, and its application prospects in tissue repair, complex wound treatment and care, cell culture, etc. are increasingly prominent. [0003] Most of the injectable hydrogels in the prior art are self-crosslinked gels, the gelation effect is not ideal, and the mechanical properties are not good. The injectable gel has a single function, and there are few reports on multi-functional injectable hydrogels. For example, the Chinese patent whose public...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J7/12C08L5/08C08L5/04A61L27/52A61L27/50A61L27/20C12N5/00
CPCC08J3/075C08J7/12A61L27/52A61L27/50A61L27/20C12N5/00C08J2305/08C08J2405/04C08J2305/04C08J2405/08A61L2400/06C12N2533/30C08L5/04C08L5/08C08L1/286
Inventor 耿志杰刘群峰于珊纪禹行国翠平裴大婷鲁道欢
Owner GUANGDONG PROV MEDICAL INSTR INST
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com