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Antibacterial drug and application thereof

A technology of antibacterial drugs and drugs, which is applied in antibacterial drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of difficult research and development of new antibiotics, long cycle, and low speed of research and development, and achieve the probability of drug resistance Low, reduce drug resistance, reduce the effect of drug dose

Inactive Publication Date: 2020-12-15
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the development speed of new drugs is far lower than the evolution speed of bacterial resistance, and the development of new antibiotics is difficult and takes a long time

Method used

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  • Antibacterial drug and application thereof
  • Antibacterial drug and application thereof
  • Antibacterial drug and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] An antibacterial drug of the present invention includes idarubicin (IDAR).

[0046] Investigate the effect of antibacterial drug of the present invention in inhibiting microorganisms, its investigation method is as follows:

[0047] Experiment 1: Investigate the minimum inhibitory concentration (MIC) of idarubicin on Staphylococcus aureus and Staphylococcus epidermidis.

[0048] Experimental process: Using the micro-broth dilution method, dilute idarubicin into solutions with concentrations of 0.313, 0.438, 0.625, 0.875, 1.25, 1.75, 2.5, 3.5, 5, 7, and 10 μg / ml, and carry out according to CLSI operate.

[0049] figure 1 It is an analysis chart of the results of different concentrations of idarubicin inhibiting methicillin-resistant Staphylococcus aureus ATCC43300 strain in Experiment 1 of the present invention. like figure 1 Shown: when the concentration is 0.875ug / ml, the growth of bacteria can be partially inhibited; when the concentration of idarubicin is 4μg / ml, t...

Embodiment 2

[0098] An antibacterial medicine that includes fosfomycin and idarubicin.

Embodiment 3

[0100] An antibacterial drug that includes amikacin and idarubicin.

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Abstract

The invention discloses an antibacterial drug and application thereof. The antibacterial drug is idarubicin. The idarubicin achieves the effect of resisting staphylococcus aureus by blocking DNA topoisomerase IIA subunit, can be applied to preparation of drugs for resisting staphylococcus aureus infection, is low in drug resistance probability, is low in cytotoxicity and cardiotoxicity after beingcombined with traditional antibiotics, and has potential to become a new antibiotic.

Description

technical field [0001] The invention relates to the field of research and development of new antibiotics, in particular to an antibacterial drug and its application. Background technique [0002] Staphylococcus aureus, referred to as Staphylococcus aureus, is a common opportunistic pathogen that causes community and hospital-acquired infections. Staphylococcus aureus can cause a variety of infections, such as skin / soft tissue infection, osteomyelitis, joint infection, bacteremia, and sepsis. With the irrational use of antibiotics, the drug resistance of Staphylococcus aureus is increasing year by year, especially the emergence of Methicillin-resistant Staphylococcus aureus (MRSA), resulting in a great increase in the resistance of Staphylococcus aureus. In addition, Staphylococcus aureus can also adhere to the surface of medical devices or human tissues to form biofilms. Compared with planktonic bacteria, the drug resistance of bacteria in the biofilm state is significantly...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K31/665A61K31/7036A61P31/04
CPCA61K31/665A61K31/7036A61K31/704A61P31/04A61K2300/00
Inventor 伍勇佘鹏飞陈丽华陈辉李颖佳袁金玲朱娟
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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