Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Anti-respiratory tract positive bacterium infection composition for livestock and poultry and application thereof

An anti-respiratory and positive bacteria technology, applied in the field of biomedicine, can solve the problems of unsatisfactory treatment effect and complex formula, and achieve the effect of good clinical treatment effect, good stability and reduction of economic loss.

Inactive Publication Date: 2020-12-18
山东齐发药业有限公司
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The veterinary doxycycline hydrochloride injection in this patent has an effect on upper respiratory tract infection caused by gram-positive cocci, but its formula is complicated and the therapeutic effect is still not ideal

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-respiratory tract positive bacterium infection composition for livestock and poultry and application thereof
  • Anti-respiratory tract positive bacterium infection composition for livestock and poultry and application thereof
  • Anti-respiratory tract positive bacterium infection composition for livestock and poultry and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1. The mensuration of minimum inhibitory concentration (MIC) and zone of inhibition in vitro

[0031] 1. Experimental materials

[0032] Test strain:

[0033] Staphylococcus aureus (S.aureus), methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE), Bacillus subtilis (B.subtilis) and large intestine Bacillus (Escherichia coli, E. coli).

[0034] Test drug:

[0035] APTM, doxycycline and 5 groups of compositions prepared by APTM and doxycycline.

[0036] The mass proportions of the specific APTM and doxycycline compositions are respectively:

[0037] Compatibility 1: APTM: doxycycline = 80:20,

[0038] Combination 2: APTM: doxycycline = 60:40,

[0039] Combination 3: APTM: doxycycline = 50:50,

[0040] Compatibility 4: APTM: doxycycline = 40:60,

[0041] Compatibility 5: APTM: doxycycline = 20:80.

[0042] Preparation method: Weigh 12.8 mg of APTM and doxycycline according to the above compatibility,...

Embodiment 2

[0061] Embodiment 2.APTM and APTM+doxycycline compound preparation are to the therapeutic effect test of mouse MRSA infection model

[0062] 1. Experimental materials

[0063] Test strain:

[0064] Methicillin-resistant Staphylococcus aureus (MRSA), catalog number: ATCC43300.

[0065] experimental drug

[0066] A compound preparation made of a composition for resisting respiratory positive bacteria infection for livestock and poultry, the preparation method of the compound preparation comprises the following steps:

[0067] Weigh 0.48g, 0.9g, 1.2g, 1.5g, 2.4g of APTM and 0.36g, 0.6g, 0.8g, 1g, 1.6g of doxycycline, mix the two components according to the mass ratio of compatibility 2, Then add 50mL dimethyl sulfoxide and 100mL Tween-80 respectively, mix and stir to dissolve completely; then add 850mL water for injection and stir evenly, adjust the pH to 7.5 with ethanolamine to obtain the total concentration of APTM and doxycycline Respectively 0.8, 1.5, 2, 2.5, 4mg / mL comp...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an anti-respiratory tract positive bacterium infection composition for livestock and poultry and application of the anti-respiratory tract positive bacterium infection composition. The composition comprises APTM and doxycycline, wherein mass ratio of the APTM to the doxycycline is (20-80): (20-80). Meanwhile, the invention also provides application of the composition in preparation of a composite preparation. According to the composition, APTM and doxycycline are combined for use, the APTM and the doxycycline can achieve a synergistic effect to show a good clinical treatment effect, under the same dosage, the composition is obviously superior to single use of APTM or doxycycline, and has a remarkable effect on respiratory tract infection caused by positive cocci.

Description

technical field [0001] The invention relates to a composition for resisting respiratory positive bacterial infection for livestock and poultry and application thereof, belonging to the field of biomedicine. Background technique [0002] Respiratory diseases of livestock and poultry are caused by one or several kinds of bacteria, viruses, parasites, chlamydia, environmental factors and other synergistic effects. It is the main disease currently affecting the development of my country's breeding industry. The morbidity and mortality of the disease are high , and easily secondary to other diseases, according to reports, the incidence of pig farms is 30-60%, the mortality rate is 5-30%, the mortality rate of chicken farms is 10-20%, and if mixed with other diseases, the mortality rate reaches 50%. % above, often causing huge economic losses to the aquaculture industry. Some zoonotic diseases also threaten human health, which has attracted widespread attention. Therefore, it is ve...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/505A61K31/65A61P31/04A61P11/00
CPCA61K31/505A61K31/65A61P11/00A61P31/04A61K2300/00
Inventor 王守奎尚若锋耿英明李霞王晓敏张淼王洛菊
Owner 山东齐发药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com