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Anti-fatigue all-hydrogel composite material as well as preparation method and application thereof

A composite material and hydrogel technology, applied in the fields of additive processing, medical science, prosthesis, etc., can solve the problems of complex simulation shape, and achieve the effect of easy industrial production and simple operation

Pending Publication Date: 2020-12-22
苏州凝智新材料发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For a long time, people have been working to develop hydrogels that can mimic or even replace the structure and function of biological tissues. The main challenge is to simulate tissues with complex shapes and cyclic loads, such as heart valves, muscles and vocal cords.

Method used

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  • Anti-fatigue all-hydrogel composite material as well as preparation method and application thereof
  • Anti-fatigue all-hydrogel composite material as well as preparation method and application thereof
  • Anti-fatigue all-hydrogel composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] This embodiment provides a kind of anti-fatigue all-hydrogel artificial heart valve, and its preparation method is as follows:

[0077] (1) The CT images of heart valves obtained in actual cases (such as figure 1 shown in A) and convert it into a fully editable 3D model (such as figure 1 shown in B); further extract features to form a frame model with a fiber structure.

[0078] (2) Use deionized water to prepare the hydrogel skeleton pre-polymerization solution, the proportion is acrylamide (AAm) 29wt%, acrylic acid (AA) 3.1wt%, lithium chloride (LiCl) 4wt%, N,N'- Methylbisacrylamide (MBAA) 0.116wt%, TPO modified photoinitiator 0.1wt% and tartrazine photoinhibitor 0.78×10 -4 g / mL.

[0079] (3) The above-mentioned pre-polymerization solution was mixed at a speed of 2000 rpm using a planetary mixer, and after removing air bubbles for 2 minutes, it was poured into a light-curing 3D printer. Here, we use an ENCA printer with a UV light intensity of 3.51mW / cm2. Import ...

Embodiment 2

[0086] This embodiment provides a kind of anti-fatigue all-hydrogel artificial heart valve, and its preparation method is as follows:

[0087] (1) Same as embodiment 1.

[0088] (2) Use deionized water to prepare the hydrogel skeleton pre-polymerization solution, the proportion is polyethylene glycol diacrylate (M-PEG, molecular weight 10000) 30wt%, acrylic acid (AA) 3.1wt%, polyethylene glycol diacrylate Acrylate (PEGDA, molecular weight 1000) 0.15 wt%, α-ketoglutaric acid 0.5 wt%.

[0089] (3) The above-mentioned pre-polymerization solution was mixed at a speed of 1000 rpm using a planetary mixer and debubbled for 4 minutes, and then poured into a light-curing 3D printer. Here, we use ENCA printer, the UV light intensity is 3.51mW / cm 2 . Import the model file to be printed obtained in step (1) into a 3D printer for slicing, with a layer thickness of 50 μm. Using the pre-polymerization solution in step (2) as a printing material, a hydrogel skeleton with this shape is obt...

Embodiment 3

[0095] This embodiment provides a kind of anti-fatigue all-hydrogel artificial heart valve, and its preparation method is as follows:

[0096] (1) Same as embodiment 1.

[0097] (2) Use deionized water to prepare the hydrogel skeleton pre-polymerization liquid, the proportion is 24wt% of acrylamide (AAm), 2.8wt% of acrylic acid (AA), 0.1 of N,N'-methylenebisacrylamide (MBAA) wt%, modified TPO photoinitiator 0.1wt% and curcumin photoinhibitor 0.6×10 -4 g / mL.

[0098] (3) The above-mentioned pre-polymerization solution was mixed at a speed of 3000rpm using a planetary mixer, and after removing air bubbles for 1min, it was poured into a light-curing 3D printer. Here, we use ENCA printer, the UV light intensity is 3.51mW / cm 2 . Import the model file to be printed obtained in step (1) into a 3D printer for slicing, with a layer thickness of 50 μm. Using the pre-polymerization solution in step (2) as a printing material, a hydrogel skeleton with this shape is obtained.

[0099...

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Abstract

The invention relates to an anti-fatigue all-hydrogel composite material as well as a preparation method and application thereof. The anti-fatigue all-hydrogel composite material comprises a hydrogelskeleton and a hydrogel matrix filling in and bonded in the hydrogel skeleton, wherein the modulus of the hydrogel skeleton is 10 times or more the modulus of the hydrogel matrix. The all-hydrogel composite material is composed of the hydrogel skeleton and the hydrogel matrix with large modulus contrast, and polymer networks of the hydrogel skeleton and the hydrogel matrix are topologically entangled; the composite material can effectively limit crack propagation, and compared with a skeleton material and a matrix material, the all-hydrogel composite material has moderate modulus, but the fracture performance of the all-hydrogel composite material exceeds 4000 J / m<2> and is greatly improved; and the fatigue threshold value of the composite material exceeds 400 J / m<2>, so the composite material has important significance for an application scene in need for bearing of cyclic load. The composite material has the same fatigue resistance as a mechanical valve and the same biocompatibilityas a tissue valve.

Description

technical field [0001] The invention belongs to the technical field of biological tissue materials, in particular to an all-hydrogel composite material and its preparation method and application, especially to an all-hydrogel composite material with complex structure, good fatigue resistance and designability and Its preparation method and application. Background technique [0002] The normal physiological function of vascular valves is to open and close periodically during blood circulation, allowing blood to flow in one direction. The valve structure bears cyclic loads and has good fatigue resistance. Hydrogels have a good similarity with biological tissues, which usually consist of a large amount of water (30-80wt%) and a polymer network. Water provides a liquid environment in which other substances can exchange and react. The polymer network maintains a solid form, resulting in properties such as modulus, toughness and fatigue resistance. Biological tissues often hav...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08F220/56C08F220/06C08F222/38C08F290/06C08F299/02B33Y70/00C08L33/26C08L51/08C08L55/00C08K3/16A61L27/52A61L27/50A61L27/48
CPCC08J3/075C08F220/56C08F290/062C08F299/026B33Y70/00A61L27/52A61L27/50A61L27/48A61L27/507C08J2333/26C08J2351/08C08J2355/00C08K3/16A61L2430/20A61L2430/30A61L2430/00C08F220/06C08F222/385
Inventor 杨航夏崟唐敬达
Owner 苏州凝智新材料发展有限公司
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