Construction and application of multifunctional hollow cerium nano-particles and hollow cerium nano-composite drug loading system
A nanocomposite and nanoparticle technology, applied in the direction of nanomedicine, nanotechnology, nanotechnology, etc., can solve the problems of restricting widespread use, and achieve the effect of improving water solubility and drug efficacy
Inactive Publication Date: 2020-12-25
CHONGQING MEDICAL UNIVERSITY
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Problems solved by technology
[0005] Chlorin e6 is an FDA-approved photosensitizer for photodynamic therapy of tumors, but it is water-insoluble, which limits its widespread use to some extent.
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Embodiment 1
[0033] Step 1. Prepare hollow cerium nanoparticles with different hollow degrees by using a one-pot hydrothermal method. First, dissolve 1.085g of cerium nitrate hexahydrate solid in 5mL ultrapure water to prepare 0.5M cerium nitrate, and then carry out 5 parallel processes. The reactions are named reactions ①, ②, ③, ④, ⑤, respectively. Next, briefly stir the mixed solution of 30mL ethylene glycol and 1mL 0.5 M cerium nitrate in a beaker at room temperature for 5min, then continue to add 2mL (0M), 0.5M, 3.5M, 7.5M, and 15M ultrapure water in parallel respectively. 2mL pure aqueous solution to react ①, ②, ③, ④, ⑤, stir briefly for 5min. Subsequently, the reaction liquids of reactions ①, ②, ③, ④, and ⑤ were transferred into the reactor, and the reactor was placed in a muffle furnace for 12 hours at 180°C. Finally, after the reaction was completed and cooled to room temperature, the reaction solution was centrifuged and washed with an appropriate amount of absolute ethanol at 50...
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The invention discloses construction and application of multifunctional hollow cerium nano-particles and a hollow cerium nano-composite drug-loading system, and relates to the technical field of advanced nano-composite materials. Due to the fact that cerium nano-particles have excellent mimic enzyme activity, in order to improve the application of the cerium nano-particles in tumor treatment, thehollow cerium nano-particles are developed to serve as a drug delivery platform. The hollow cerium nano-particles are prepared by adopting a one-pot hydrothermal method, synthesis raw materials are easy to obtain, the method is simple and rapid, the hollow degree of the hollow cerium nano-particles can be accurately controlled, the method can be used for industrial production, and a product has strong biomimetic enzyme activity; and the constructed hollow cerium nano-composite drug loading system is good in stability, keeps the bionic enzyme activity, improves the water solubility and drug effect problems of drugs, responds to selective oxygen supply in a tumor acidic microenvironment, and improves the photodynamic curative effect.
Description
Technical field: [0001] The invention relates to a preparation method and application of nanomaterials for clinical treatment of solid tumors, especially bionic hollow cerium nanoparticles synthesized based on a one-pot hydrothermal method, and surface biological modification to construct nanocarriers to form hollow cerium Nanocomposite, loaded with therapeutic drugs to construct a drug-loaded system to achieve visual tracking, and exert a powerful photodynamic therapy effect on tumors. The synthesis method reported in the present invention can realize precise control of the hollow degree of hollow cerium nanoparticles, and the product has strong biomimetic enzyme activity; the constructed hollow cerium nanocomposite drug-loading system has good stability, maintains biomimetic enzyme activity, improves The problem of water solubility and efficacy of the drug, and the selective oxygen supply in response to the tumor micro-acid environment can improve the photodynamic efficacy; ...
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IPC IPC(8): A61K33/244A61K47/54A61K47/69A61P15/14A61P35/00B22F1/00B22F9/24B82Y5/00B82Y40/00
CPCA61K33/244A61K47/545A61K47/6949A61P15/14A61P35/00B22F9/24B82Y5/00B82Y40/00B22F1/07B22F1/054
Inventor 阳章友周丽于超
Owner CHONGQING MEDICAL UNIVERSITY