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Synthesis method and application of biodegradable high-molecular-weight polyester

A high molecular weight, biodegradable technology, applied in the field of biodegradable high molecular weight polyester preparation, can solve the problems of large capillary phenomenon, inability to process films, dark polyester color, etc., achieve excellent mechanical and thermal properties, improve biodegradation The effect of improving performance and thermal decomposition temperature

Pending Publication Date: 2020-12-29
WUHAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2,5-furandicarboxylic acid (FDCA) and ethylene glycol (EG) can be derived from biomass, which can reduce the dependence of the production of polyester products on petroleum-based raw materials, but the use of ethylene glycol and 2,5-furandicarboxylic acid as The raw material is polyester synthesized by esterification and polycondensation method, which has poor transparency, darker color and low molecular weight, which cannot meet the requirements for chromaticity and mechanical properties of surgical sutures, and has a large capillary phenomenon , prone to infection complications ［2］ ([2] Cui Hongxing, Zhang Qian. Research progress of surgical sutures [J]. Biotechnology, 2005, 2005(07): 25-31.) Moreover, the obtained polyester has poor tensile properties and cannot be processed into super thin film

Method used

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  • Synthesis method and application of biodegradable high-molecular-weight polyester

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: 1.000 g (6.0 mmol) of 2,6-dipicolinic acid, 0.667 g (6.0 mmol) of 2,4-dihydroxypyridine and 0.002 g of ethyl titanate were sequentially added to a 50 mL single-necked flask, and the reaction The used mixture was reacted for 4.0 h at 165° C. under the protection of nitrogen. Then raise the temperature to 210° C., and react for 3.0 h under a pressure environment of 15 KPa to obtain a crude polymer product. After cooling the crude polymer product, add a certain amount of chloroform, shake to promote dissolution, and add isopropanol to the filtrate after filtration until the precipitate produced no longer increases. The filter residue obtained after filtration was washed with ethanol, and then vacuum-dried at 60°C for 3.0h to obtain polyester P 1 , its weight-average molecular weight is 279,330Da, the molecular weight distribution is 4.9, and the yield is 90.05%.

[0025] Polyester P 1 High molecular weight, transparent, used as the main component of surgical ...

Embodiment 2

[0030] Example 2: Add 1.000g (6.0 mmol) of 2,6-dipicolinic acid, 0.678g (6.1mmol) of 2,5-dihydroxypyridine and 0.002g of ethyl titanate to a 50mL single-necked flask in sequence. The mixture was reacted at 165°C for 4.0 h under nitrogen protection. Then raise the temperature to 210° C., and react for 3.0 h under a pressure environment of 15 KPa to obtain a crude polymer product. After cooling the crude polymer product, add a certain amount of chloroform, shake to promote dissolution, and add isopropanol to the filtrate after filtration until the precipitate produced no longer increases. The filter residue obtained after filtration was washed with ethanol, and then vacuum-dried at 60°C for 3.0h to obtain polyester P 2 , its weight average molecular weight is 263,3227Da, the molecular weight distribution is 3.6, and the yield is 90.09%.

[0031] Polyester P 2 High molecular weight, transparent, used as the main component of surgical suture processing, the method is as follows...

Embodiment 3

[0033] Example 3: 1.000 g (6.0 mmol) of 2,6-dipicolinic acid, 0.678 g (6.1 mmol) of 2,3-dihydroxypyridine and 0.002 g of bis(triethanolamine) titanic acid were sequentially added to a 50 mL single-necked flask Diisopropyl ester, the reaction mixture was reacted at 165°C for 4.0h under the protection of nitrogen. Then raise the temperature to 210° C., and react for 3.0 h under a pressure environment of 15 KPa to obtain a crude polymer product. After cooling the crude polymer product, add a certain amount of chloroform, shake to promote dissolution, and add isopropanol to the filtrate after filtration until the precipitate produced no longer increases. The filter residue obtained after filtration was washed with ethanol, and then vacuum-dried at 60°C for 3.0h to obtain polyester P 3 , its weight average molecular weight is 230,338Da, the molecular weight distribution is 3.0, and the yield is 91.05%.

[0034] Polyester P 3 High molecular weight, transparent, used as the main c...

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Abstract

The invention discloses a synthesis method and application of biodegradable high-molecular-weight polyester, and belongs to the field of polyester synthesis. 2, 6-pyridine dicarboxylic acid and a dihydroxyl compound are used as raw materials, and a series of novel biodegradable high-molecular-weight polyesters are synthesized by adopting a melt polymerization method. The synthesis method comprisesthe following steps: under the protection of N2, stirring the raw materials at 160-185 DEG C under the action of a catalyst to react for 4.0-5.0 hours, heating to 200-220 DEG C, reacting for 2.0-3.5hours in a 5-15 KPa environment, and vacuumizing for 2.0-3.0 hours to obtain a polymer crude product; cooling the crude product, adding chloroform, dissolving, filtering, and adding ethanol or propanol and other low-carbon alcohols into the filtrate until no precipitate is generated; centrifugally filtering, washing the obtained precipitate with ethanol to remove impurities, and carrying out vacuum drying at 50-60 DEG C for 3.0-4.0 hours to obtain the required high-molecular-weight polyester. The weight-average molecular weight Mw value of the obtained polyester is 210,000 280,000 Da, and themolecular weight distribution Mw / Mn value is as wide as 3.0-4.9. The high-molecular-weight polyester prepared by the invention can be used as a main component of a medical material surgical suture andcan also be used as a flexible and foldable curved display panel base material.

Description

technical field [0001] The invention belongs to the technical field of biodegradable polyester, and in particular relates to a preparation method of biodegradable high molecular weight polyester. Using 2,6-pyridinedicarboxylic acid and nitrogen-containing dihydroxy compounds as raw materials, a series of polymer biodegradable new polyesters are synthesized by melt polymerization, which can be used as the main component of medical materials and surgical sutures, and can also be used as Substrates for flexible foldable curved curved display panels. Background technique [0002] With the development of the plastics industry, synthetic polymer materials play an extremely important role in various fields of industrial and agricultural production and daily life. However, due to some excellent properties of plastic, it is not easy to rot after use, and it accumulates over time, seriously affecting the ecological environment of the earth. It is urgent to seek an environmentally ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/685C08G63/90C08G63/85A61L17/10C08J7/044C08J7/06C08J5/18G09F9/30C08L67/02
CPCC08G63/6856C08G63/90C08G63/85A61L17/105A61L17/10C08J7/044C08J7/06C08J5/18G09F9/301C08J2367/02C08L67/02C08L31/04C08L29/04C08L29/14C08L23/34
Inventor 程正载熊景陈俊马里奥高斯尔孙欣贾如艳袁贝贝天威
Owner WUHAN UNIV OF SCI & TECH
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