Method for preparing nicotinamide mononucleotide

A single nucleotide and nicotinamide technology, applied in the direction of fermentation, etc., can solve the problems of high cost of NMN process, achieve the effect of reducing production cost, complete conversion of raw materials, and simple operation of synthesis reaction
CN112159831AActive Publication Date: 2021-01-01湖州颐盛生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
湖州颐盛生物科技有限公司
Publication Date
2021-01-01

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Abstract

The invention provides a method for preparing nicotinamide mononucleotide. The method is characterized by using hypoxanthic acid and / or guanylic acid, ATP and nicotinamide as raw materials, carrying out combined catalytic reaction by using ribosidase, ribose pyrophosphate kinase and nicotinamide ribose phosphate transferase, and synthesizing by using a one-pot method to obtain nicotinamide mononucleotide. The method opens up a new way for synthesizing nicotinamide mononucleotide by an enzyme method, and significantly reduces the production cost.
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Description

Technical field

[0001] The invention belongs to the technical field of biocatalysis, and relates to a method for preparing nicotinamide mononucleotide, and specifically, to a new method for enzymatically synthesizing nicotinamide mononucleotide.Background technique

[0002] Nicotinamide mononucleotide (β-Nicotinamide mononucleotide, referred to as β-NMN or NMN) is an endogenous substance in the human body. It is the product of nicotinamide phosphoribosyl transferase reaction and participates in intracellular nicotinamide purine dinucleoside Acid (NAD+The synthesis of) is its important and most direct prerequisite substance. In the human body, NMN is converted into NAD+Exercising its physiological functions, such as activating NAD+The substrate-dependent enzyme Sirt1 (histone deacetylase, also known as sirtuin), regulates cell survival and death, and maintains redox state. But it will gradually decrease with age. Thanks to NAD+The molecular weight is too large to be absorbed by the human b...

Claims

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