Targeted antibiosis and in-situ osteogenesis promoting bifunctional material as well as preparation method and application thereof

A dual-functional material and bone-promoting technology, which can be used in pharmaceutical formulations, prostheses, drug delivery, etc., can solve problems such as poor treatment effect, inability to fully fill periodontal defects, and reduced patient comfort and compliance
CN112220967AActive Publication Date: 2021-01-15SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2021-01-15

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Abstract

The invention provides a targeted antibiosis and in-situ osteogenesis promoting bifunctional material as well as a preparation method and application thereof, and belongs to the technical field of periodontal tissue repair and regeneration. The bifunctional material comprises a gel scaffold and SDF-1, wherein the gel scaffold is formed by cross-linking PEG-DA and Peptide, has a temperature-sensitive characteristic and can respond to gingipains, and the SDF-1 is further loaded by the material and has a recruited stem cell homing function. By developing and preparing the gingipain response typetemperature-sensitive gel material, long-acting targeted antibiosis and in-situ regeneration promotion of a periodontal defect part can be realized simultaneously along with release of short antibacterial peptide and the SDF-1. Tests prove that the PEG-DA-Peptide@SDF-1 bifunctional material prepared by the invention is temperature-sensitive and can be applied by injection, and has good long-actingtargeted antibiosis and in-situ regeneration promoting effects, so that the bifunctional material has good practical application value.
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Description

Technical field

[0001] The invention belongs to the technical field of periodontal tissue repair and regeneration, and specifically relates to a targeted antibacterial and in-situ bone-promoting dual-function material, and a preparation method and application thereof.Background technique

[0002] Disclosure of the background information is only intended to increase the understanding of the overall background of the present invention, and is not necessarily regarded as an acknowledgement or in any form suggesting that the information constitutes the prior art known to those of ordinary skill in the art.

[0003] Periodontitis is a periodontal disease caused by the infection of various anaerobic pathogens such as Porphyromonasgingivalis (P.gingivalis). The alveolar bone resorption caused by it is considered to be adult loss of teeth The main reason. Periodontitis not only causes bleeding, ulceration and loose teeth in the gums, but also has a close relationship with systemic diseases such as di...

Claims

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