Shape memory polymer material for esophageal stent, preparation method and application method

A memory polymer and control method technology, applied in the field of polymer materials, can solve problems such as difficult implantation positions, tissue thermal damage, and precise adjustment, and achieve the effects of simple preparation process, high tensile stress, and high application prospects

Active Publication Date: 2021-01-22
ZHEJIANG UNIV
View PDF14 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the shape memory materials reported so far still face many shortcomings, making it difficult to apply to the human body.
First of all, the shape memory response temperature of most current shape memory polymer materials is much higher than the normal body temperature of the human body, so that they cannot be triggered to expand by themselves after being implanted in the human body to realize the support of the...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Shape memory polymer material for esophageal stent, preparation method and application method
  • Shape memory polymer material for esophageal stent, preparation method and application method
  • Shape memory polymer material for esophageal stent, preparation method and application method

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0081] 5. Application of the shape memory polymer material made by the preparation method of the shape memory polymer material

[0082] Application of shape memory polymer materials in esophageal stents.

[0083] Embodiments of the present invention are as follows:

Embodiment 1

[0085] 331.0 mg of polytetrahydrofuran diacrylate, 220.4 mg of polyethylene glycol diacrylate, 45.8 mg of pentaerythritol tetra-3-mercaptopropionate, and 5.5 mg of benzoin dimethyl ether were dissolved in 1.1 ml of chloroform solution. After ultrasonically obtaining a uniform transparent precursor solution, inject the precursor solution into the transparent mold, remove air bubbles, and seal. Place the mold under a 365nm ultraviolet lamp for cross-linking and polymerization for 1.5 hours, then take out the fully cross-linked polymer from the mold and vacuum-dry it in a 40°C oven to constant weight to obtain a two-way reversible shape memory with human body temperature response and human body temperature, Water-responsive triple shape memory polymer material.

[0086] The polytetrahydrofuran diacrylate used in this example has a molecular weight of 2900 g / mol and a melting point of 26.0 °C. The polyethylene glycol diacrylate used had a molecular weight of 4000 g / mol and a melt...

Embodiment 2

[0095] 275.4 mg of polytetrahydrofuran diacrylate, 274.9 mg of polyethylene glycol diacrylate, 43.9 mg of pentaerythritol tetra-3-mercaptopropionate, and 5.5 mg of benzoin dimethyl ether were dissolved in 1.1 ml of chloroform solution. After ultrasonically obtaining a uniform transparent precursor solution, inject the precursor solution into the transparent mold, remove air bubbles, and seal. Place the mold under a 365nm ultraviolet lamp for cross-linking polymerization for 1.5 hours, then take out the fully cross-linked polymer from the mold and vacuum-dry it in a 40°C oven to constant weight to obtain a two-way reversible shape memory with human body temperature response and human body temperature, Water-responsive triple shape memory polymer material. The material exhibits good two-way shape memory properties between -20 °C and 37 °C, with a reversible strain of 9.73%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Melting pointaaaaaaaaaa
Melting pointaaaaaaaaaa
Melting pointaaaaaaaaaa
Login to view more

Abstract

The invention discloses a shape memory polymer material for an esophageal stent and a preparation method thereof. The shape memory polymer material is prepared from, by mass, 30-60 parts of hydrophilic crystallizable macromonomer, 40-70 parts of hydrophobic crystallizable macromonomer and 1-10 parts of cross-linking agent through a polymerization reaction, wherein the hydrophilic crystallizable macromonomer is polyethylene glycol diacrylate, the hydrophobic crystallizable macromonomer is polytetrahydrofuran diacrylate, and the cross-linking agent is pentaerythritol tetra-3-mercaptopropionate.The material is simple to prepare, light and soft in texture and degradable, has the self-unfolding, adjustable and drug sustained-release capacity in a human body environment when serving as an esophageal stent material and shows a higher application prospect.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a shape-memory polymer material used for esophageal stents, a preparation method and an application method thereof. Background technique [0002] Esophageal cancer is a cancer with a high incidence in my country, and the five-year survival rate of patients is less than 15%. Esophageal stent implantation is an important means of palliative treatment for patients with advanced esophageal cancer. However, traditional esophageal stent materials commonly used in clinical practice are mostly metal materials, which will cause greater pain to patients because of their high rigidity after being implanted into the human body. Metal stents are difficult to degrade and face problems of rectification and recycling once released in the human body. In addition, the traditional esophageal stent can only play a simple supporting role, and can only relieve the symptoms of e...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L31/06A61L31/14C08F299/02
CPCA61L31/06A61L31/14A61L2400/16C08F2/48C08F299/024C08F299/028C08L71/02
Inventor 俞豪杰梁瑞雪王立
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap