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Two-dimensional nanomaterial vascular plaque scavenger, M2 macrophage inducer and cell autophagy modulator

A two-dimensional nanomaterial, vascular plaque technology, applied in the field of atherosclerotic drugs, to achieve the effect of promoting autophagy, increasing fluidity, and good biological activity

Pending Publication Date: 2021-02-02
SHENZHEN PKU HKUST MEDICAL CENT +1
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  • Claims
  • Application Information

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Problems solved by technology

[0006] In view of this, the present invention provides two-dimensional nanomaterial vascular plaque remover, two-dimensional nanomaterial M2 macrophage inducer and two-dimensional nanomaterial cell autophagy regulator, to solve the technical problems existing in the prior art

Method used

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  • Two-dimensional nanomaterial vascular plaque scavenger, M2 macrophage inducer and cell autophagy modulator
  • Two-dimensional nanomaterial vascular plaque scavenger, M2 macrophage inducer and cell autophagy modulator

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Embodiment Construction

[0021] Drug efficacy test: APOE- / - mice were fed with common feed as the control group, and APOE- / - mice were fed with high-fat feed as the model group. After 12 weeks, the AS mouse model was successfully established, and the concentrations were injected through the tail vein respectively. 0.1 mg / ml of three kinds of two-dimensional nanoparticles, blood samples were collected after 1 week, and then the mice were sacrificed, the aortic tree was completely stripped, and stained with Sudan IV staining solution.

[0022] Data processing: SPSS20.0 statistical analysis software was used to conduct statistical analysis on the data, and the independent sample t test method was used to conduct statistical analysis on the experimental results, and the statistical data selection (mean ± standard deviation) was expressed. Plaque area size was calculated using Image J. Blood samples were analyzed for macrophage content and serum oxidation rate using hematology analyzer, ultraviolet spectro...

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Abstract

The invention belongs to the technical field of atherosclerosis drugs, and particularly relates to a two-dimensional nanomaterial vascular plaque scavenger, an M2 macrophage inducer and a cell autophagy modulator. Three atherosclerosis drugs all adopt boron alkene nanoparticles and / or black scale nanoparticles as main components. The two-dimensional nanomaterial atherosclerosis drugs provided by the invention can promote the autophagy process of cells through the peroxidation effect of surface active groups, can induce more M2 macrophages to be released in the degradation process, can purify blood through the physical adsorption effect, and can increase the flowability of blood, and therefore, the effect of quickly removing atherosclerosis lesion lipid waste to intervene and control plaqueformation can be achieved. Meanwhile, the black phosphorus nanoparticles and the boron alkene nanoparticles also have very good biological activity, biocompatibility and natural degradability, and donot cause any drug damage to a human body.

Description

technical field [0001] The invention belongs to the technical field of atherosclerosis medicines, and in particular relates to a two-dimensional nanomaterial vascular plaque remover, a two-dimensional nanomaterial M2 macrophage inducer and a two-dimensional nanomaterial cell autophagy regulator. Background technique [0002] Atherosclerosis (AS) is a chronic inflammatory disease that mainly occurs in middle-aged and elderly people. The basis of its pathological changes is derived from the initial lipid metabolism. Accumulate and form a lipid core; inflammation and hemodynamic factors lead to plaque rupture, leading to ulcers and fissures, loss of normal endothelial cells, and exposure of necrotic lipid core; proliferation and rupture of new blood vessels in the plaque lead to intraplaque hemorrhage, cause thrombosis. The core material of the plaque is the continuous accumulation of foam cells evolved from a large amount of lipid waste. One of the key factors to reduce plaq...

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Application Information

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IPC IPC(8): A61K33/22A61K33/42A61P9/10B82Y5/00
CPCA61K33/22A61K33/42A61P9/10B82Y5/00A61K2300/00
Inventor 陈芸郑婷婷彭佼张雪陈珂珂宋宇健崔光辉成官迅戚玉龙陈办成
Owner SHENZHEN PKU HKUST MEDICAL CENT
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