Preparation method and application of bioactive material containing nano calcium fluoride

A bioactive, calcium fluoride technology, applied in pharmaceutical formulations, dental preparations, molded cups, etc., can solve problems such as gingival irritation, inability to release periodontal tissue biological ions, progress of periodontitis, etc., to promote tooth formation Osteogenic differentiation, good mechanical properties, and the effect of promoting osteogenic differentiation

Active Publication Date: 2021-02-05
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current filling resin materials are irritating to the gums, which will lead to the further development of periodontal inflammation. At the same time, ordinary filling materials cannot release biological ions that are beneficial to the regeneration of periodontal tissue.

Method used

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  • Preparation method and application of bioactive material containing nano calcium fluoride
  • Preparation method and application of bioactive material containing nano calcium fluoride
  • Preparation method and application of bioactive material containing nano calcium fluoride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A preparation method of a biologically active material containing nano-calcium fluoride, comprising the steps of:

[0034] (1) Glycidyl methacrylate and triethylene glycol dimethacrylate are mixed at a mass ratio of 1:1, called BT, and then BT is mixed with camphorquinone and 4-(N,N-diethylamino ) ethyl benzoate is mixed, and the mass ratio of the three is 100:0.2:0.8 to obtain mixture A.

[0035] (2) Mix barium boroaluminosilicate glass particles with 3-(methacryloyloxy)propyltrimethoxysilane and n-n-propylamine in a mass ratio of 100:4:2, then stir with magnetic force Stir in a mixer at room temperature overnight until the liquid is clear and transparent to obtain mixture B.

[0036] (3) The bioactive material containing nano-calcium fluoride is obtained after mixing the nano-calcium fluoride with the mixture A and the mixture B, and the mass ratio of the three is 10:30:60.

[0037] (4) Molding the bioactive material prepared above: ①Use the lid of a sterile 96-well...

Embodiment 2

[0039] In step (3), the mass ratio of nano-calcium fluoride to mixture A and mixture B is 15:30:55, and all the other operations are the same as in Example 1.

Embodiment 3

[0041] In step (3), the mass ratio of nano-calcium fluoride to mixture A and mixture B is 20:30:50, and all the other operations are the same as in Example 1.

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Abstract

The invention discloses a preparation method and application of a bioactive material containing nano calcium fluoride, and belongs to the technical field of dental biomaterials. The preparation methodcomprises the following steps: mixing glycidyl methacrylate and triethylene glycol dimethacrylate in a mass ratio of 1: 1 to obtain a mixture called BT, and then mixing the BT with camphorquinone and4-(N,N-diethylamino) ethyl benzoate in a mass ratio of 100: 0.2: 0.8 to obtain a mixture A; mixing the aluminoborosilicate barium glass particles with 3-(methacryloyloxy) propyltrimethoxysilane and n-propylamine and then performing stirring with a magnetic stirrer, and standing overnight at normal temperature until liquid is clear and transparent to obtain a mixture B; and mixing the nano calciumfluoride with the mixture A and the mixture B. Compared with the prior art, the preparation method has the beneficial effects that the bioactive material into which the nano calcium fluoride is addednot only has a good mechanical property, but also can slowly release fluorine ions and calcium ions, and is beneficial to regeneration of periodontal tissues.

Description

technical field [0001] The invention relates to the technical field of dental biomaterials, in particular to a preparation method and application of a bioactive material containing nanometer calcium fluoride. Background technique [0002] Periodontitis and root caries are mutually causal. The occurrence of root caries is related to age and the amount of cementum exposed in the oral cavity. Periodontitis will also be aggravated by the retention of food and plaque caused by root caries. Periodontitis can lead to gingival recession, exposing the root surface, and increasing the occurrence of root caries. Filling treatment is still the main method at present. [0003] The materials used for filling are amalgam, composite resin and glass ionomer composite, the most commonly used of which is composite resin. Composite resin is composed of resin matrix and inorganic fillers. It has greater tensile strength and less expansion, shrinkage and deformation during curing. Its most prom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/887A61K6/831A61K6/836A61K6/60
CPCA61K6/887A61K6/836A61K6/831A61K6/60C08L33/14C08L35/02
Inventor 刘瑾徐华焜李昂代泉
Owner XI AN JIAOTONG UNIV
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