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Asiaticoside gel dressing for external use and preparation method thereof

A technology of asiaticoside and gel is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. Removal, easy application, prolonged effect

Pending Publication Date: 2021-02-05
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide an asiaticoside external gel dressing that can promote rapid wound healing and a preparation method thereof, using the gel dressing as a carrier, designing an asiaticoside external drug delivery system based on the gel dressing carrier, It aims to solve the problems that traditional dressings are easy to stick to the wound surface, and it is easy to cause secondary damage to the wound surface when changing the dressing, and to develop a topical drug delivery system for asiaticoside with compliance, effectiveness and safety.

Method used

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  • Asiaticoside gel dressing for external use and preparation method thereof
  • Asiaticoside gel dressing for external use and preparation method thereof
  • Asiaticoside gel dressing for external use and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Preparation of asiaticoside gel dressing for external use based on carboxymethyl chitosan, sodium alginate, glycerol and potassium sorbate.

[0025] Table 1 prescription composition

[0026] composition Proportion(%) Asiaticoside 0.2 PEG400 0.006 Carboxymethyl chitosan 0.3 sodium alginate 0.6 glycerin 3 Potassium sorbate 0.24 CaCl 2

[0027] According to the prescription ratio in Table 1, add carboxymethyl chitosan and sodium alginate to distilled water under constant stirring, and stir overnight until the matrix is ​​fully swollen, then mix sodium alginate solution and carboxymethyl chitosan solution Evenly, add glycerin and potassium sorbate and mix evenly, add pH regulator to adjust the pH value to near neutral, add asiaticoside PEG400 solution, mix evenly, slowly add CaCl dropwise under high-speed stirring 2 And EDTA-2Na, which should be clear and transparent, uniform and fine, moderate fluidity, moderate viscos...

Embodiment 2

[0029] Preparation of asiaticoside gel dressing for external use based on carboxymethyl chitosan, sodium alginate, glycerol and potassium sorbate.

[0030] Table 2 Prescription Composition

[0031]

[0032]

[0033] According to the prescription ratio in Table 3, respectively add carboxymethyl chitosan and sodium alginate to distilled water under constant stirring, and stir overnight until the matrix is ​​fully swollen, then mix the sodium alginate solution and carboxymethyl chitosan solution Evenly, add glycerin and potassium sorbate and mix evenly, add pH regulator to adjust the pH value to near neutral, add asiaticoside PEG400 solution, mix evenly, slowly add CaCl dropwise under high-speed stirring 2 And EDTA-2Na, which should be clear and transparent, uniform and fine, moderate fluidity, moderate viscosity semi-solid hydrogel, to achieve the original purpose of the design.

Embodiment 3

[0035] Preparation of asiaticoside gel dressing for external use based on carboxymethyl chitosan, sodium alginate, glycerol and potassium sorbate.

[0036] Table 3 prescription composition

[0037] composition Proportion(%) Asiaticoside 0.2 PEG400 0.006 Carboxymethyl chitosan 0.3 sodium alginate 0.6 glycerin 6 Potassium sorbate 0.24 CaCl 2

[0038] According to the prescription ratio in Table 3, respectively add carboxymethyl chitosan and sodium alginate to distilled water under constant stirring, and stir overnight until the matrix is ​​fully swollen, then mix the sodium alginate solution and carboxymethyl chitosan solution Evenly, add glycerin and potassium sorbate and mix evenly, add pH regulator to adjust the pH value to near neutral, add asiaticoside PEG400 solution, mix evenly, slowly add CaCl dropwise under high-speed stirring 2 And EDTA-2Na, which should be clear and transparent, uniform and fine, moderate fluidity...

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Abstract

The invention discloses asiaticoside gel dressing for external use and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. According to the invention, an original ointment is improved by combination with the properties of medicines and the characteristics of surgical local application, and the asiaticoside gel dressing for external use is prepared by taking a gel dressing as a carrier. The external hydrogel dressing is simple in prescription and process, high in water content, capable of providing a mild and moist healing environment for a wound surface, and suitable for symptoms such as burns, wounds, keloids and scleroderma.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to an asiaticoside external gel dressing capable of promoting rapid wound healing and a preparation method thereof. Background technique [0002] Asiaticoside (Asiaticoside, AC), also known as Asiaticoside or Asiaticoside, is the main active ingredient of the traditional Chinese medicine Centella asiaticoside, and its molecular formula is C 48 h 78 o 19 , the molecular weight is 959.123. Asiaticoside is light yellow powder, odorless and tasteless, easily soluble in methanol, insoluble in ether and chloroform, the equilibrium solubility at 25°C is 305.02μg / mL, and the oil-water distribution coefficient in n-octanol-water is 2.248. Studies have shown that asiaticoside has pharmacological effects such as promoting wound healing, preventing scars, anti-inflammation, anti-depression, and anti-tumor; and asiaticoside has also been shown to be effective i...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61K9/06A61K47/36A61K47/10A61K31/7024A61P17/02
CPCA61L26/008A61L26/0066A61L26/0023A61L26/0019A61K9/06A61K9/0014A61K47/36A61K47/10A61K31/7024A61P17/02A61L2300/23A61L2300/412
Inventor 蒋曙光涂迎盈赵新宇
Owner CHINA PHARM UNIV
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