Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Vitamin oral liquid as well as preparation method and application thereof

A vitamin and oral liquid technology, applied in the field of vitamin oral liquid and its preparation, can solve the problems of low bioavailability, reduced fat solubility, reduced permeability, etc., and achieve improved product safety, good stability, and microbial stability good effect

Active Publication Date:
View PDF7 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the vitamin is salted, its water solubility is greatly improved, and its fat solubility is reduced. During the transmembrane transport, its permeability will also be greatly reduced, resulting in the problem of low bioavailability.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Vitamin oral liquid as well as preparation method and application thereof
  • Vitamin oral liquid as well as preparation method and application thereof
  • Vitamin oral liquid as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] This embodiment provides a vitamin oral liquid of the present invention and a preparation method thereof. Vitamin oral liquid is shown in Table 1.

[0044] Table 1

[0045]

[0046] Weigh 60% of the prescribed amount of purified water, add the prescribed amount of sorbitol, heat and stir to dissolve (the temperature is controlled at 80-90° C.). Then add the prescribed amount of B vitamins 2 Stir to dissolve. After dissolving, the liquid was cooled to room temperature to obtain mixed solution 1;

[0047] Add the prescribed amount of vitamin E into the prescribed amount of Tween 80 and stir to dissolve to obtain the mixed solution 2. Afterwards, it is transferred to the mixed solution 1 to obtain the mixed solution 3;

[0048] Add the prescribed amount of edetate disodium, acesulfame potassium, and carboxymethyl cellulose sodium into the mixed solution 3 and stir to dissolve to obtain the mixed solution 4;

[0049] Weigh the prescribed amount of vitamin D 3 Form...

Embodiment 2

[0054] This embodiment provides a vitamin oral liquid of the present invention and a preparation method thereof. It is the same as Example 1, the only difference is that the concentration of sorbitol in the vitamin oral liquid is 250g / L, and the mass ratio of vitamin E (content is 15mg / 15ml), sorbitol and Tween 80 is 1:250 :6. The content of sodium carboxymethyl cellulose is 153mg / 15ml, that is, the mass-to-volume ratio of sodium carboxymethyl cellulose to water in the mixed liquid three is 17 mg / mL. Vitamin D 3 The mass ratio to carboxymethyl cellulose sodium is 1:10000. The viscosity of the prepared vitamin oral liquid at 30° C. is 50 cp.

Embodiment 3

[0056] This embodiment provides a vitamin oral liquid of the present invention and a preparation method thereof. It is the same as Example 1, except that the concentration of sorbitol in the vitamin oral liquid is 350g / L, and the mass ratio of vitamin E (content is 15mg / 15ml), sorbitol and Tween 80 is 1:350 :8. The content of sodium carboxymethyl cellulose is 207mg / 15ml, that is, the mass-to-volume ratio of sodium carboxymethyl cellulose to water in the mixed liquid three is 23 mg / mL. Vitamin D 3 The mass ratio to carboxymethyl cellulose sodium is 1:14000. The viscosity of the prepared vitamin oral liquid at 30° C. is 220 cp.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention relates to the technical field of medicinal preparation processing, and particularly discloses vitamin oral liquid as well as a preparation method and application thereof. The vitamin oral liquid includes vitamin B2, vitamin D and vitamin E, and its preparation method comprises the following steps: (1) mixing an aqueous solution of sorbitol with vitamin B2 to obtain a mixed solutionI; (2) mixing vitamin E with a surfactant to obtain a mixed solution II, and adding the mixed solution II into the mixed solution I to obtain a mixed solution III; (3) adding a thickening agent into the mixed solution III to obtain a mixed solution IV; and (4) adding an ethanol solution of vitamin D into the mixed solution IV. The oral liquid containing the water-soluble vitamin and the fat-soluble vitamins, obtained by the invention, has good physicochemical and microbial stability.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparation processing, in particular to a vitamin oral liquid and its preparation method and application. Background technique [0002] Vitamin is a general term for a series of organic compounds. They are trace nutrients needed by the human body, but generally cannot be produced by the human body itself, and need to be obtained through diet and other means. Vitamins regulate the metabolism of the human body. [0003] Vitamins can be divided into water-soluble and fat-soluble vitamins according to their solubility. Fat-soluble vitamins include vitamin A, vitamin D, vitamin E and vitamin K, and the rest are water-soluble vitamins. When multivitamins are prepared in tablet form, they tend to be poorly absorbed in the body. And when it is prepared into an oral solution, its stability problem is particularly prominent. [0004] Chinese patent CN103690561A discloses a preparation method of...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/59A61K31/525A61K31/355A61K45/06A61K9/08A61K47/26A61K47/38A61P3/02
CPCA61K31/525A61K31/59A61K31/355A61K9/0095A61K45/06A61K47/26A61K47/38A61P3/02A61K2300/00
Inventor 田兵黄娜李磊米俊成王娟
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com