1, 2, 4-triazole derivative compound and application thereof in treating inflammatory bowel disease

A technology of derivatives and compounds, applied in the direction of drug combinations, anti-inflammatory agents, digestive system, etc., can solve problems that have not been reported, achieve good preventive or therapeutic effects, and good development prospects
CN112341399APending Publication Date: 2021-02-09王剑
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
王剑
Publication Date
2021-02-09

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Abstract

The invention belongs to the field of medicines, and relates to a 1, 2, 4-triazole derivative compound and application thereof in treatment of inflammatory bowel diseases. The structural formula of the 1, 2, 4-triazole derivative compound is shown as a formula I. In a 3% dextran sodium sulfate induced mouse ulcerative colitis model, the compound prepared by the invention has a remarkable improvement effect.
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Description

technical field

[0001] The invention belongs to the field of medicine and relates to a 1,2,4-triazole derivative compound and its application in treating inflammatory bowel disease. Background technique

[0002] Inflammatory bowel disease involves chronic inflammation of all or part of the digestive tract. The two main forms of inflammatory bowel disease are ulcerative colitis and Crohn's disease. The most common symptoms of ulcerative colitis are diarrhea and blood in the stool. The disease is of unknown etiology, the result of an interaction of environmental, genetic, and microbial factors, and is characterized by periodic quiescence and outbreaks. Ulcerative colitis has no sex difference, and the peak age of onset is between 30 and 40 years old. Currently, the incidence and prevalence of ulcerative colitis are increasing worldwide.

[0003] Clinically, the purpose of drug therapy for ulcerative colitis is mainly to relieve clinical symptoms, that is, to stop blood in ...

Claims

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