Rhodamine-benzothiazole functionalized photosensitive probe as well as synthesis method and application thereof

A technology of benzothiazole and synthesis method, which is applied in the field of chemical detection to achieve the effects of improving stability, broad application and promotion prospects, and wide applicable pH range
CN112341471AActive Publication Date: 2021-02-09XIAN UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XIAN UNIV OF SCI & TECH
Publication Date
2021-02-09

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Abstract

The invention belongs to the technical field of chemical detection, and relates to a rhodamine-benzothiazole functionalized photosensitive probe, and a synthesis method and application thereof. The structure of the rhodamine-benzothiazole functionalized photosensitive probe can be used for ClO<-> detection and detection of ClO<-> in cells. The rhodamine-benzothiazole functionalized photosensitiveprobe provided by the invention has a six-membered spirohydrazide structure, the stability of probe molecules is high, the reaction binding sites of the probe are increased,and good biocompatibility is obtained; and the probe can be used for detecting ClO<-> in environment and biological cells, has the characteristics of good anti-interference capability, short response time, long fluorescence duration, wide pH application range, high detection sensitivity and wide detection concentration range, and presents important scientific research value and wide application and popularization prospects.
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Description

technical field

[0001] The invention belongs to the technical field of chemical detection, and relates to a rhodamine-benzothiazole functionalized photosensitive probe, a synthesis method and an application. Background technique

[0002] Reactive oxygen species (ROS), including superoxide radicals (O 2 ·- ), hydroxyl radical (OH·), peroxyl radical (ROO·), hydrogen peroxide (H 2 o 2 ), singlet oxygen ( 1 o 2 ) and hypochlorous acid and hypochlorite (HClO / ClO - ), are closely related to numerous physiological and pathological processes such as signal conversion, neuropathic injury, inflammation and carcinogenesis. Hypochlorous acid and hypochlorite exist together to regulate physiological pH and are an important ROS. As a very effective antibacterial agent and bleaching agent in daily life, hypochlorous acid is widely used in the disinfection of water quality such as tap water and swimming pools. In cells, it can quickly oxidize the amino groups in amino acids to chlor...

Claims

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