A kind of preparation method of 2-fluoro-5-formyl chloride pyridine
A technology of formyl chloride pyridine and picoline, which is applied in the field of preparation of 2-fluoro-5-formyl chloride pyridine, can solve the problems that there is no very mature process technology report, and achieve the effect of low production cost and high conversion rate
Active Publication Date: 2022-03-04
内蒙古佳瑞米精细化工有限公司
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Abstract
The invention relates to a preparation method of 2-fluoro-5-formyl chloride pyridine, which belongs to the technical field of organic chemistry. The method steps are: 1) using 2-fluoro-5-picoline as a raw material, reacting in the presence of potassium permanganate or sodium permanganate to obtain 2-fluoro-5-picoic acid pyridine; 2) using 2- Fluoro-5-formyl pyridinium and thionyl chloride or oxalyl chloride are refluxed in a chlorinated solvent. After the reaction is over, after the solvent is distilled under reduced pressure, add an alkane solvent to freeze and filter to obtain a 2-fluoro-5-formyl chloride pyridine solution. Rectification under reduced pressure gives 2-fluoro-5-formyl chloride pyridine. The invention has the advantages of high conversion rate, the purity of the obtained product is as high as 99.0 percent, the purity of the product is less than 0.5 percent, the production cost is low, and it is suitable for industrialized production.
Application Domain
Organic chemistry
Technology Topic
Sodium permanganateFormic acid +8
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PUM
Property | Measurement | Unit |
Melting point | 275.0 ~ 278.0 | °C |
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