An adhesive layered matrix and uses thereof
A technology of adhesive layer and multi-layer matrix, applied in the direction of synthetic resin layered products, applications, surgical adhesives, etc., which can solve the problems of damage, slow down time, etc.
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Embodiment 1
[0354] Electrospun elastic sheets were prepared as previously described (WO 2015 / 092797). The following polymers were electrospun using the general procedure described previously (molecular weights herein refer to weight average molecular weight unless otherwise stated):
[0355] PLLA-poly(L-lactic acid) homopolymer (molecular weight 150±5kDa);
[0356] PLLA / CL-poly(L-lactic acid-co-ε-caprolactone) (molar ratio 70:30 lactic acid: caprolactone, molecular weight 210±10kDa);
[0357] PCL / LLA / GA / TMC – poly(ε-caprolactone-co-L-lactic acid-co-glycolic acid-co-trimethylene carbonate) linear block copolymer (35:34:17 molar ratio: 14 caprolactone: lactic acid: glycolic acid: trimethylene carbonate, the molecular weight is 165 ± 5kDa, the number average molecular weight is 90 ± 5kDa);
[0358] Next, viscoelastic sheets were prepared by film casting or electrospinning as previously described in WO 2015 / 092797.
Embodiment 2
[0360] Activated adhesive layer
[0361] After irradiation to activate the adhesive layer, the nanofiber patches were subjected to lap shear testing. Patches are silane-treated to increase adhesion to the adhesive.
[0362] Material:
[0363] Fiber patch; High Q bond – permanent adhesive resin cement (dual cure) – BJM Laboratories; 3-methacryloxypropyl-trimethoxysilane (MEMO); N-2-aminoethyl - 3-Aminopropyltrimethoxysilane (DAMO).
[0364] method:
[0365] Silane solutions were prepared using 1 and 2% DAMO and MEMO silanes in a mixture of 99% ethanol and 1% water. The patches were immersed in the silane solution and dried at room temperature (RT) for 24 hours, and the contact angle was measured.
[0366] figure 1 with 2 A schematic of a monolithic 3-layer matrix with an adhesive layer that can be selectively activated by radiation curing in selected areas is presented.
[0367] Double lap shear samples were prepared using PC strips as a substrate, as can be found in ...
Embodiment 3
[0376] Adhesion test
[0377] Adhesion of the nanofiber patches to fascial tissue was tested in a lap shear test. Patches are silane-treated to increase adhesion to the adhesive. Comparison of treated and untreated patch silanes. Samples without adhesive were also tested for comparison.
[0378] Material:
[0379] Nanofiber patch; High Q bond – permanent adhesive resin cement (dual cure) – BJM Laboratories; 3-methacryloxypropyl-trimethoxysilane (MEMO); bovine fascia tissue.
[0380] method:
[0381] Silane solutions were prepared using 2% MEMO in a mixture of 99% ethanol and 1% water. The patches were dipped in the silane solution and allowed to dry at room temperature for 24 hours. Such as Figure 4 Lap-shear samples were prepared using strips of the nanofiber patch as shown in . Strips (7mm L x 3mm W) from nanofiber patches (silane-treated and non-treated) were cut, and an area of -4mmL x 3mm W was bonded to the fascial tissue. Expose the sample to a UV lamp for 5...
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