Isothiazolinone compound soluble powder and preparation process thereof

Abstract

The invention provides isothiazolinone compound soluble powder which is prepared from the following components: a main drug: 2.5-20g of an isothiazolinone compound, 2.5-20g of a cosolvent, 6-30g of apolymer solubilizing and stabilizing agent composition, wherein the polymer solubilizing and stabilizing agent composition is a mixture obtained by uniformly mixing and stirring a polymer compound 1 and a polymer compound 2 according to a ratio of 2: 1, and the auxiliary material is 50.0-89.0, and the total weight of the components is 100g after the components are mixed; appropriate additives suchas the cosolvent, the polymer solubilizer and the stabilizer are selected out through screening, and the obtained finished product can be quickly dissolved in tap water in use and can be used for purifying a poultry drinking water pipeline; the preparation process is simple and convenient, the quality is controllable, and the safety is high; the isothiazolinone compound soluble powder is stable in property in a three-year storage process and good in stability within one week when being dissolved in water, and the defect that a conventional solution of the compound is unstable is overcome.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a soluble powder of isothiazolinone compounds and a preparation process thereof. Background technique [0002] In various farms such as large-scale chicken farms, a lot of biofilm, dirt, drug residues and other substances are often accumulated in water supply pipelines and drinking fountains, which breed a large number of pathogenic microorganisms such as bacteria, fungi, algae, etc., causing water tanks , water line, and drinking fountains are blocked, resulting in no water from the drinking fountains, or the water is too slow, making it impossible for livestock and poultry to drink water normally. In addition, with unclean pipelines, livestock and poultry will be forced to drink polluted water, which will cause chickens to get sick, thereby reducing production performance and increasing costs. Although the use of antibacterial drugs for chickens can treat diseases ...

AI Technical Summary

Problems solved by technology

However, these compounds are insoluble in water and unstable in water

At present, the used or published patent inventions are mainly liquid preparations, such as chloromethylisothiazolinone / methylisothiazolinone (CMIT / MIT) solution, benzisothiazolinone (BIT ) solution, etc., but its storage period is short (only 1 year), and stabilizers (metal nitrates, formaldehyde, metal bromates, copper salts, etc.) need to be added. These stabilizers have safety problems for poultry. In addition Organic solvents used in the preparation of solutions should not be used in poultry drinking water lines