Application of fluorine-substituted 2-aminothiazole-5-aromatic carboxamide

Abstract

The application of the invention relates to an application of a compound of a formula I or pharmaceutically acceptable salt, ester, solvate, prodrug, active metabolite, crystal, stereoisomer, tautomeror geometric isomer thereof, or a medical composition comprising the compound of the formula I or the pharmaceutically acceptable salt, the ester, the solvate, the prodrug, the active metabolite, thecrystal, the stereoisomer, the tautomer or the geometrical isomer to preparation of drugs for preventing or treating tyrosine kinase related diseases.

Description

technical field

[0001] The application belongs to the field of medicinal chemistry, in particular to a fluorine-substituted 2-aminothiazole-5-aromatic carboxamide for the treatment and prevention of diseases and disorders or its pharmaceutical composition in diseases associated with tyrosine kinases (such as immune preventive or therapeutic use in diseases such as diseases, tumors and neurological diseases). Background technique

[0002] Protein kinases are a class of enzymes that catalyze the phosphorylation of proteins, thereby altering their substrate activity or ability to bind to other proteins. Kinase signaling is the most common form of reversible post-translational modification and controls many aspects of cellular function. Aberrant activation of protein kinases is a major hallmark of malignancy, including alterations in cell proliferation, survival, motility, and metabolism, as well as disorders such as angiogenesis and evasion of antitumor immune responses. [0...

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