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New application of stachyose in the preparation of drugs for preventing and/or treating polycystic ovary syndrome

A polycystic ovary and stachyose technology, applied in the field of stachyose, can solve the problems of dose dependence and large side effects in the human body, and achieve the effects of promoting rapid proliferation, restoring ovulation function, and reducing the number of populations

Active Publication Date: 2021-11-30
BEIJING OBSTETRICS & GYNECOLOGY HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a new application of stachyose in the preparation of medicines for the treatment and / or prevention of polycystic ovary syndrome, so as to solve the problem that the medicines commonly used in the symptomatic treatment of polycystic ovary syndrome have large side effects on the human body and have high doses. dependence and other issues, the present invention uses stachyose for the treatment of polycystic ovary syndrome for the first time

Method used

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  • New application of stachyose in the preparation of drugs for preventing and/or treating polycystic ovary syndrome
  • New application of stachyose in the preparation of drugs for preventing and/or treating polycystic ovary syndrome
  • New application of stachyose in the preparation of drugs for preventing and/or treating polycystic ovary syndrome

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The construction of embodiment 1 animal model

[0067] Three-week-old SD rats were divided into three groups: the control group, the PCOS model group, and the stachyose treatment group, with 9-11 rats in each group. The construction method of each group of rat models is as follows:

[0068] (1) Control group (Oil+Saline group): 200 μL of sesame oil was subcutaneously injected for 21 consecutive days, followed by intragastric administration of normal saline for 12 consecutive days.

[0069] (2) PCOS model group (DHEA+Saline group): Subcutaneous injection of dehydroepiandrosterone (DHEA) (Solarbio, D8950) 6 mg / 100 g, 200 μL, continuous injection for 21 days, followed by intragastric administration of normal saline for 12 consecutive days.

[0070] (3) Stachyose treatment group (DHEA+STA group): subcutaneous injection of dehydroepiandrosterone (DHEA) (6mg / 100g, 200μL), after continuous injection for 21 days, stachyose (TCI, S0397 ) (200mg / kg).

[0071] Weighing was perf...

Embodiment 2

[0072] Example 2 The observation of rat estrous cycle, the observation of ovarian histomorphology and the measurement and analysis of serum hormones 1, the observation of rat estrous cycle

[0073] Rats are animals with multiple estrus throughout the year and have a relatively stable sexual cycle, which is divided into: preestrus (P), estrus (E), postestrus (M) and diestrus (D). The vaginal mucosa of each period is Typical changes occur, which stage can be judged according to the cytological characteristics of the vaginal smear. In this embodiment, 3 rats in the control group (Oil+Saline group), PCOS model group (DHEA+Saline group), and stachyose treatment group (DHEA+STA group) three groups of experimental animals were treated at the same time every afternoon. The vaginal cell smears were taken for 10 consecutive days, stained with Wright's staining solution (LEAGENE, 1029A20) to observe the cell morphology, and the experimental results were recorded and counted.

[0074] 2....

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Abstract

The present invention discloses a new application of stachyose in the preparation of drugs for preventing and / or treating polycystic ovary syndrome. The present invention applies stachyose extracted from natural plants to research related to polycystic ovary syndrome for the first time. It is also proved for the first time that stachyose can significantly improve the ovulation dysfunction of PCOS and restore the ovulation function of rats. Compared with the traditional medicines currently commonly used for symptomatic treatment, stachyose will not cause any side effects and dependence on the human body, and stachyose can be well and rationally utilized by intestinal beneficial bacteria, which is beneficial to clinical treatment. And / or adjuvant treatment of PCOS is of great significance.

Description

technical field [0001] The present invention relates to the new application of stachyose, especially the new application of stachyose in the preparation of drugs for preventing and / or treating polycystic ovary syndrome. Background technique [0002] Stachyose (STA) is a tetrasaccharide with a structural formula of fructose-glucose-galactose-galactose and a molecular formula of C 24 h 42 o 21 . The sugar is a functional oligosaccharide without any dependence, and its calories are 1.5-2.4kcal / g. It is refined and extracted from natural plants. The pure product is a white powder with a slightly sweet taste, which is 22% of that of sucrose. It has a pure taste without any bad taste or peculiar smell. It can enter the colon and be fermented and utilized by intestinal bacteria. Stachyose has a very obvious proliferation effect on beneficial bacteria such as bifidobacteria and lactobacilli in the human gastrointestinal tract, and can quickly improve the environment in the huma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/702A61P15/08A61P1/00
CPCA61K31/702A61P1/00A61P15/08
Inventor 李天鹤阴赪宏刘瑞霞高惠民
Owner BEIJING OBSTETRICS & GYNECOLOGY HOSPITAL CAPITAL MEDICAL UNIV