Transdermal penetration-promoting composition and application thereof in timolol preparation

Abstract

The invention provides a transdermal penetration-promoting composition for improving the transdermal absorption effect of timolol. The transdermal penetration-promoting composition is prepared from 65-98wt% of albolene and 2-35wt% of wax substances. The transdermal penetration-promoting composition can achieve the cumulative penetration amount of timolol of about 92.61 micrograms per square centimeter within 8 hours without additionally using other conventional transdermal penetration-promoting agents, the transdermal absorption promoting effect is remarkable, the skin irritation is low, and the safety is higher.

Description

technical field

[0001] The invention relates to a transdermal penetration enhancer, in particular to a composition mainly composed of various substances, which is beneficial to drug transdermal absorption, and its application in timolol preparations. Background technique

[0002] Infantile hemangiomas (IH) are one of the most common childhood benign tumors in the world. According to literature reports, the incidence rate of common neonatal hemangiomas is 1.1% to 2.6%, and premature infants can reach 10% or even higher. The incidence rate of girls is three times that of boys (Chinese Journal of Oral and Maxillofacial Surgery, 2011, 9(1): 61-67). Early literature reports that most infantile hemangiomas do not require treatment, but about 12% of high-risk patients may have to receive treatment due to the impact on organ function or even life-threatening. At present, in view of the potential harm of IH to children's physiology and psychology, especially the special site and spe...

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