Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Stoma skin protective agent and preparation method thereof

A technology of skin protectant and antiseptic, applied in the field of stoma skin protectant and its preparation, can solve the problem of no curative effect of intestinal stoma, achieve the effect of increasing antibacterial and anti-inflammatory ability, alleviating skin inflammation, and low cost

Inactive Publication Date: 2021-03-12
湖北省亨德利医疗器械有限公司
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this composition is only effective for urostomy, and has no effect on intestinal stoma

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Stoma skin protective agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. Formula

[0032] The stoma skin protection agent of this embodiment is composed of the following components: 70 g of distilled water, 5 g of glycerin, 0.5 g of chitosan, 0.5 g of lactic acid, 10 g of panthenol, 0.1 g of preservative phenoxyethanol, and 1 g of purslane extract .

[0033] 2. Preparation method:

[0034] 2.1 Preparation of purslane extract

[0035] (1) Take 20g of purslane powder, add it into 70vol% ethanol solution according to the ratio of material to liquid of 1:10, heat and stir for extraction, and keep warm at 80°C for two hours;

[0036] (2) Filtration of the extract in step (1), adding 0.5wt% activated carbon to the filtrate, and incubating at 60°C for half an hour;

[0037] (3) The material in step (2) is centrifugally filtered to obtain a purslane extract solution; concentrated, evaporated to dry ethanol, and the concentrated solution is freeze-dried to obtain a purslane extract.

[0038] 2.2 Hydrogel Preparation

[0039] (1) Take 0.425-0....

Embodiment 2

[0045] 1. Formula

[0046] The stoma skin protection agent of this embodiment is composed of the following components: 75g of distilled water, 8g of glycerin, 5g of chitosan, 2g of lactic acid, 5g of panthenol, 0.5g of preservative phenoxyethanol, and 4.5g of purslane extract.

[0047] 2. Preparation method:

[0048] 2.1 The preparation of purslane extract is the same as in Example 1.

[0049] 2.2 Hydrogel Preparation

[0050] (1) Take 1.7-1.9g lactic acid and fully dissolve in distilled water to form an acid solution, dissolve glycerin in the acid solution, and fully homogenize;

[0051] (2) under continuous stirring condition, chitosan is slowly added in the solution that step (1) obtains, until dissolving completely;

[0052] (3) Add preservatives, purslane extract and panthenol to the solution obtained in step (2) successively, and fully dissolve;

[0053](4) adding the remaining lactic acid to the solution in step (3) to adjust the pH of the solution to 5.0 to 6.0;

...

Embodiment 3

[0056] 1. Formula

[0057] The stoma skin protection agent of the present embodiment is composed of the following components: 80 g of distilled water, 7 g of glycerin, 8 g of chitosan, 5 g of malic acid, 1 g of panthenol, 5 g of antiseptic polyaminopropyl biguanide, and 10 g of purslane extract .

[0058] 2. Preparation method:

[0059] 2.1 The preparation of purslane extract is the same as in Example 1.

[0060] 2.2 Hydrogel Preparation

[0061] (1) Get 4.25-4.75g malic acid and fully dissolve in distilled water to form an acid solution, dissolve glycerin in the acid solution, and fully homogenize;

[0062] (2) under continuous stirring condition, chitosan is slowly added in the solution that step (1) obtains, until dissolving completely;

[0063] (3) Add preservatives, purslane extract and panthenol to the solution obtained in step (2) successively, and fully dissolve;

[0064] (4) adding the remaining malic acid to the solution of step (3) to adjust the pH of the solut...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a stoma skin protective agent and a preparation method thereof, chitosan is fully dissolved in water, chitosan is used as a hydrogel matrix, hydrogel is obtained by using chitosan with molecular weight of 25000g / mol to 150000g / mol and deacetylation grade higher than 85%, and the stoma skin protective agent has better antibacterial effect compared with many hydrogel such asPVA and PVP hydrogel on the market; in order to improve the properties of the hydrogel, purslane and at least one preservative are added, so that the antibacterial and anti-inflammatory effects are further improved; meanwhile, the panthenol is added and interacts with other components, so that the damaged skin can be repaired, and the generation of new cells is accelerated. The protective agent disclosed by the invention is good in treatment effect, can effectively relieve skin inflammation of a stoma patient, and particularly can effectively help healing when the skin of the stoma patient isulcerated.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a stoma skin protectant and a preparation method thereof. Background technique [0002] The stoma is caused by diseases of the digestive system or urinary system. It is necessary to separate the intestinal tube through surgical treatment, and lead one end of the intestinal tube to the body surface (anus or urethra is moved to the abdominal wall) to form an opening to achieve intestinal decompression, Reduce obstruction, protect the anastomosis or damage of the distal intestine, promote the recovery of intestinal and urinary tract diseases, and even save the patient's life. Stomas are generally for rectal and bladder lesions (such as rectal cancer, bladder cancer, intestinal obstruction, etc.). In order to save the patient's life, the doctor surgically removes the lesion. For example, rectal cancer will remove the rectum and anal canal, and bladder cancer will remove ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/34A61K36/185A61K31/722A61K31/164A61P17/02
CPCA61K9/0014A61K9/06A61K31/164A61K31/722A61K36/185A61K47/34A61K47/36A61P17/02A61K2300/00
Inventor 陈雷
Owner 湖北省亨德利医疗器械有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com