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Fluorescent antibacterial carbon dot as well as preparation method and application thereof

A carbon dot and fluorescence technology, applied in antibacterial drugs, nano-carbon, pharmaceutical formulations, etc., can solve the problems of cumbersome preparation method of fluorescent antibacterial carbon dots, low antibacterial activity of carbon dots, and easy formation of drug resistance, etc. Bactericidal efficacy, avoidance of drug resistance, high antibacterial activity

Active Publication Date: 2021-03-16
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Description
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Problems solved by technology

[0005] In view of the defects of the prior art, the object of the present invention is to provide a fluorescent antibacterial carbon dot, its preparation method and application, aiming to solve the tedious preparation method of the prior art fluorescent antibacterial carbon dot, the prepared carbon dot antibacterial activity is not high or Technical problems such as high toxicity and easy formation of drug resistance

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  • Fluorescent antibacterial carbon dot as well as preparation method and application thereof
  • Fluorescent antibacterial carbon dot as well as preparation method and application thereof
  • Fluorescent antibacterial carbon dot as well as preparation method and application thereof

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preparation example Construction

[0042]In the prior art, carbon dots are usually coupled and modified with substances with antibacterial function to achieve bacterial imaging and inhibition, or fluorescent antibacterial carbon dots are prepared through cumbersome preparation methods, but most of the prepared carbon dots have low antibacterial activity. Poor biocompatibility, poor stability, etc. In view of these problems, the present invention creatively proposes a preparation method of fluorescent antibacterial carbon dots, by specially selecting chitosan quaternary ammonium salt or chitosan as a carbon source to heat and prepare carbon dots, which can be synthesized in one step to obtain At the same time, blue luminescent carbon dots for imaging and killing bacteria can be realized, and the preparation method is simple and green. The prepared antibacterial functional carbon dots not only have high antibacterial activity, but also have good water dispersibility, low cost, low cytotoxicity and hemolysis. The ...

Embodiment 1

[0066] (1) Weigh 200 mg of chitosan quaternary ammonium salt and disperse it in 20 mL of ultrapure water, then stir under a magnetic stirrer to obtain a uniformly dispersed transparent solution.

[0067] (2) Transfer the transparent solution obtained in step (1) to a polytetrafluoroethylene reactor, and react in an oven at 200° C. for 4 hours to obtain a carbon dot solution, whose fluorescence spectrum is as follows: figure 2 As shown, the particle size characterization results are shown in image 3 .

[0068] (3) Put the carbon dot solution obtained in step (2) directly into a 500D dialysis bag for 24 hours of dialysis and then dry to obtain solid carbon dots.

Embodiment 2

[0070] (1) Weigh 200 mg of chitosan quaternary ammonium salt and disperse it in 20 mL of ultrapure water, then stir under a magnetic stirrer to obtain a uniformly dispersed transparent solution.

[0071] (2) Transfer the transparent solution obtained in step (1) to a polytetrafluoroethylene reactor, and react in an oven at 200° C. for 6 hours to obtain a carbon dot solution, whose fluorescence spectrum is as follows: figure 2 As shown, the fluorescence intensity is relatively weak compared with Example 1, and its MIC to Staphylococcus aureus is 40 μg / mL.

[0072] (3) Put the carbon dot solution obtained in step (2) directly into a 500D dialysis bag for 24 hours of dialysis and then dry to obtain solid carbon dots.

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Abstract

The invention belongs to the technical field of nano functional materials, and particularly relates to a fluorescent antibacterial carbon dot as well as a preparation method and application thereof. Chitosan quaternary ammonium salt or chitosan is specially selected as a carbon source to be heated to prepare the carbon dot, the blue light-emitting carbon dot capable of imaging and killing bacteriaat the same time can be synthesized in one step, and the preparation method is simple. The prepared functional carbon dot is high in antibacterial activity, good in water dispersibility, low in cost,low in cytotoxicity and low in hemolytic activity.

Description

technical field [0001] The invention belongs to the technical field of nano functional materials, and more specifically relates to a fluorescent antibacterial carbon dot, its preparation method and application. Background technique [0002] In recent years, with the development and popularization of antibiotics, some diseases caused by bacterial infections have been suppressed to a large extent. However, due to some complex mechanisms, pathogens can destroy the host's immune system and cause transport obstacles, so that small molecule antibacterial agents such as antibiotics cannot effectively reach the affected area to inhibit the bacteria; at the same time, due to the abuse of antibiotics, bacterial resistance has also caused Therefore, the development of new antibacterial agents is an urgent challenge nowadays. [0003] With the rise of nanomaterials, nanomaterials have been widely used in biomedicine related fields due to their modifiability, quantum size effect, abilit...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61P31/04A61K49/00C01B32/15
CPCA61K33/44A61P31/04A61K49/0019C01B32/15Y02A50/30
Inventor 赵丹刘雪梅郝健
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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