Bionic nano delivery system and preparation method and application thereof

A delivery system, biomimetic nanotechnology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problem that the loading efficiency of magnetic nanoparticles is difficult to reach a high level, and achieve the effect of inhibiting tumor growth and proliferation

Pending Publication Date: 2021-03-16
GUANGZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The existing technology uses cancer cell membranes to modify magnetic nanoparticles loaded with chemotherapy drugs. Doxorubicin is also highly toxic, and the loading efficiency of magnetic nanoparticles is difficult to reach a high level.

Method used

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  • Bionic nano delivery system and preparation method and application thereof
  • Bionic nano delivery system and preparation method and application thereof
  • Bionic nano delivery system and preparation method and application thereof

Examples

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Embodiment 1

[0073] This example is used to illustrate the preparation of the homotype targeting biomimetic nano-delivery system of the present invention.

[0074] (1) Preparation of mesoporous silica-coated gold nanorods (MSG). First, sodium borohydride (NaBH 4 ) to tetrachloroauric acid (HAuCl 4 ) for chemical reduction to prepare cetyltrimethylammonium bromide (CTAB)-coated gold seeds. 7.5mL 0.1MCTAB mixed with 250μL 10mM HAuCl 4 Add water to 9.4 mL. Then add ice-cold NaBH at a concentration of 0.01M 4 Solution 0.6mL, stir well. Dissolve 240 μL gold seeds in 100 mL 0.1M CTAB, 5 mL 0.01M HAuCl 4 ,0.8mL10mM AgNO 3 ,2mL0.5M H 2 SO 4 And 800μL 0.1M ascorbic acid mixed solution, the temperature was kept at 30 ℃ under the condition of constant growth, to generate gold nanorod particles. Centrifuge at 9500rpm for 25 minutes to collect gold nanorod particles, dilute the precipitate with 20mL of water, then add 200μL of 0.1M sodium hydroxide solution and stir evenly. Add 60 μL methano...

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Abstract

The invention provides a bionic nano delivery system. The bionic nano delivery system comprises a core formed by gold nanorods wrapped by mesoporous silica, and the core is wrapped by a mixed membraneof cancer cell membranes and erythrocyte membranes; the bionic nano delivery system has a photothermal effect under irradiation of near-infrared light, preferably 808nm laser. The invention further provides a preparation method and application of the bionic nano delivery system. The bionic nano delivery system can specifically recognize homologous cancer cells and accumulate the cancer cells, after the cancer cells enter the cells, drugs are accurately and efficiently released under irradiation of 808nm laser, cancer cell apoptosis is caused, cancer tissue is ablated, and therefore tumor growth is inhibited.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to a bionic mesoporous nano-delivery system and its preparation method and application. Background technique [0002] Based on studies of tumor pathogenesis, chemotherapy is an effective and widely used cancer treatment. However, successful chemotherapy, such as the widely used doxorubicin hydrochloride, kills cancer cells as well as damages normal cells. [0003] In the past 20 years, nanomedicine has made great progress in cancer diagnosis and treatment. However, there is still a gap between nanoparticle-based therapeutic platforms and the goals of clinical cancer treatment. The main challenge is that nanoparticles for in vivo application must cross several biological barriers to reach tumor cells, including systemic blood circulation, tumor accumulation, tumor penetration, cellular internalization, and intracellular drug release. [0004] Thermal chemotherapy med...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/04A61K47/46A61P35/00B82Y5/00B82Y40/00A61K31/704
CPCA61K41/0052A61K31/704A61K47/02A61K47/46A61P35/00B82Y5/00B82Y40/00A61K2300/00
Inventor 张灵敏余细勇李欢林忠晓
Owner GUANGZHOU MEDICAL UNIV
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