Sulfadiazine silver cream and preparation method thereof

A technology of silver sulfadiazine and sulfadiazine, which is applied in the field of preparation of medicinal cream, can solve problems affecting product quality and safety of clinical medication, easy discoloration of silver sulfadiazine cream, rapid increase in impurity content, etc., to reduce sulfadiazine Redox reaction between pyrimidine silver and external metal ions, maintaining color and quality, and high product quality

Pending Publication Date: 2021-03-19
广东恒健制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinically used products have uneven drug dispersion, coarse paste particle size, and poor spreadability, which increases the risk of secondary injury to patients with severe burns
In addition, silver sulfadiazine cream is easy to change color, and the impurity content rises rapidly, which affects the product quality and the safety of clinical medication

Method used

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  • Sulfadiazine silver cream and preparation method thereof
  • Sulfadiazine silver cream and preparation method thereof
  • Sulfadiazine silver cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] This embodiment provides a silver sulfadiazine cream and its preparation method. The silver sulfadiazine cream includes the following raw materials: silver sulfadiazine 1kg, edetate disodium 0.01kg, dibutyl hydroxytoluene 0.05kg, ethylparaben 0.05kg, glyceryl monostearate 3.5kg, glycerin 8.5kg , cetostearyl alcohol 6.2kg, white petrolatum 3.6kg, light liquid paraffin 6.5kg, stearic acid 3.5kg, sodium lauryl sulfate 2.3kg and purified water 64.79kg. A total of 100kg.

[0051] The preparation method of sulfadiazine silver emulsifiable paste comprises the following steps carried out in sequence:

[0052] (1) Add silver sulfadiazine to glycerin, stir to make the two disperse evenly, and set aside;

[0053] (2) Cetostearyl alcohol, glyceryl monostearate, stearic acid, white vaseline, dibutyl hydroxytoluene, light liquid paraffin and ethylparaben are added to the oil phase pot, heated and dissolved, and Insulate at 85°C for 30 minutes, and cool to about 75°C after the end ...

Embodiment 2

[0062] This embodiment provides a silver sulfadiazine cream and its preparation method. Silver sulfadiazine cream includes the following raw materials: silver sulfadiazine 1kg, disodium edetate 0.03kg, dibutyl hydroxytoluene 0.02kg, ethylparaben 0.1kg, glyceryl monostearate 2.5kg, glycerin 8.5kg , cetostearyl alcohol 7.5kg, white petrolatum 4.5kg, light liquid paraffin 8.5kg, stearic acid 2.5kg, sodium lauryl sulfate 1kg and purified water 63.85kg. A total of 100kg.

[0063] The preparation method of sulfadiazine silver emulsifiable paste comprises the following steps carried out in sequence:

[0064] (1) Add silver sulfadiazine to glycerin, stir to make the two disperse evenly, and set aside;

[0065] (2) Cetostearyl alcohol, glyceryl monostearate, stearic acid, white vaseline, dibutyl hydroxytoluene, light liquid paraffin and ethylparaben are added to the oil phase pot, heated and dissolved, and Insulate at 85°C for 30 minutes, and cool to about 75°C after the end of the ...

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Abstract

The invention discloses a sulfadiazine silver cream and a preparation method thereof, and relates to the technical field of medicinal cream preparation. The cream is high in stability, not prone to discoloring and high in product quality. Meanwhile, the invention also provides a preparation method of the sulfadiazine silver cream, and the sulfadiazine silver cream prepared by the method is uniformin content, smooth and fine, moderate in consistency, good in spreading property and relatively fine in medicine granularity, and meets the standard requirements of pharmacopeia.

Description

technical field [0001] The invention relates to the technical field of medicinal cream preparation, in particular to a silver sulfadiazine cream and a preparation method thereof. Background technique [0002] Silver sulfadiazine cream has the dual effects of sulfadiazine and silver salt, it has a broad antibacterial spectrum, has antibacterial activity against most Gram-positive and Gram-negative bacteria, and has astringent effect, which can make the wound dry, scab and heal early . Clinically, silver sulfadiazine cream is mostly used to treat secondary wound infection of burns. Because of its definite curative effect, it has been included in the National Essential Drug List. The products currently in clinical use have uneven drug dispersion, coarse paste particle size, and poor spreadability, which increases the risk of secondary injury to patients with severe burns. In addition, silver sulfadiazine cream is easy to change color, and the impurity content rises rapidly, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K9/06A61K47/18A61K47/14A61K47/20A61K47/10A61P31/04A61P17/02A61K31/635
CPCA61K33/38A61K31/635A61K9/06A61K47/183A61K47/18A61K47/14A61K47/20A61K47/10A61P31/04A61P17/02
Inventor 韩垂银陈少波施慧敏陈妙秀吴焕玲陈彩焕邓浩健马均乐
Owner 广东恒健制药有限公司
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