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Compound, traditional Chinese medicine probiotic fermentation product and application thereof to preparation of medicine or health care product with senescence delaying effect

A technology of fermentation products and compounds, which is applied in the field of biomedicine, can solve the problems of low absorption and utilization, and achieve the effects of reducing MDA content, delaying aging, and improving antioxidant capacity

Pending Publication Date: 2021-03-19
刘志刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these methods have certain innovations, they still use the traditional extraction and preparation methods, and the absorption and utilization rate of the human body is low, so there are certain limitations.

Method used

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  • Compound, traditional Chinese medicine probiotic fermentation product and application thereof to preparation of medicine or health care product with senescence delaying effect
  • Compound, traditional Chinese medicine probiotic fermentation product and application thereof to preparation of medicine or health care product with senescence delaying effect
  • Compound, traditional Chinese medicine probiotic fermentation product and application thereof to preparation of medicine or health care product with senescence delaying effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] The preparation of embodiment 1 formula (I) compound

[0077] (1) Take Chinese medicine raw materials and add 10 times of water to extract, soak for 60 minutes, and ultrasonically extract for 60 minutes; concentrate the extract to 1 / 3 volume to obtain a concentrated solution; then add fermented nutrients to the concentrated solution; then add probiotics at a temperature of Ferment for 36 hours at 37°C and pH 7.0 to obtain a fermentation broth;

[0078] (2) centrifuging the fermentation broth at 8000r / min for 30min, removing the precipitate and retaining the supernatant, and freeze-drying the supernatant to obtain a crude product;

[0079] (3) separating the crude product by chromatographic techniques to obtain the compound of formula (I);

[0080] The traditional Chinese medicine raw materials described in step (1) are composed of perilla, astragalus, lily, rhodiola rosea, privet lucidum, panax notoginseng, ginkgo biloba, mint and gorgon in a weight ratio of 1:1:1:1:1:...

Embodiment 2

[0087] The preparation of embodiment 2 traditional Chinese medicine probiotic fermentation product

[0088] (1) Take Chinese medicine raw materials and add 10 times of water to extract, soak for 60 minutes, and ultrasonically extract for 60 minutes; concentrate the extract to 1 / 3 volume to obtain a concentrated solution; then add fermented nutrients to the concentrated solution; then add probiotics at a temperature of Ferment for 36 hours at 37°C and pH 7.0 to obtain a fermentation broth;

[0089] (2) centrifuging the fermented liquid at 8000r / min for 30 min, removing the precipitate and retaining the supernatant, and freeze-drying the supernatant to obtain a traditional Chinese medicine probiotic fermentation product;

[0090] The traditional Chinese medicine raw materials described in step (1) are composed of perilla, astragalus, lily, rhodiola rosea, privet lucidum, panax notoginseng, ginkgo biloba, mint and gorgon in a weight ratio of 1:1:1:1:1:1: 1:1:1 composition (that ...

experiment example 1

[0095] Experimental example 1 Experiment of oxidative damage induced by D-galactose on mice induced by fermented products of traditional Chinese medicine probiotics and monomeric compounds of formula (I)

[0096] (1) Animal grouping and feeding

[0097] 70 healthy mice were taken, fed at 18-22°C under natural light, free to eat and drink, and fed with common feed for 5 days under these conditions. The mice were randomly divided into 5 groups, (normal control group (Control), and model control group (DG), Chinese medicine extract group (TCM) prepared in Comparative Example 1, Chinese medicine probiotic fermentation product group prepared in Example 2 (TCMPM) and the monomer compound group (TPMSC) with the structure of formula (I), except the normal control group, the other groups received abdominal injection of 700 mg / (kg·d) D-galactose to establish the oxidative damage model, and the traditional Chinese medicine extract group , the traditional Chinese medicine probiotic ferme...

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Abstract

The invention relates to the technical field of biomedicine, and particularly discloses a compound, a traditional Chinese medicine probiotic fermentation product and application thereof to preparationof a medicine or a health care product with a senescence delaying effect. The traditional Chinese medicine probiotic fermentation product comprises a compound as shown in a formula (I) in the description. A preparation method of the compound comprises the following steps: (1) taking traditional Chinese medicine raw materials, and fermenting the traditional Chinese medicine raw materials with probiotics to obtain fermentation liquor; and (2) drying the fermentation liquor to obtain the traditional Chinese medicine probiotic fermentation product; wherein the traditional Chinese medicine raw materials in the step (1) comprise perilla frutescens, astragalus membranaceus, lily, rhodiola rosea, fructus ligustri lucidi, pseudo-ginseng, folium ginkgo, herba menthae and semen euryales. The compound shown in the formula (I) and the traditional Chinese medicine probiotic fermentation product have excellent effects of resisting oxidation and delaying senescence, and can be used for preparing themedicine and the health-care product.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a compound, a traditional Chinese medicine probiotic fermentation product and its application in the preparation of medicines or health care products with the effect of delaying aging. Background technique [0002] As the individual grows with age, there will be graying of hair, tooth loss, muscle atrophy, hardening of blood vessels, slow sensory response, memory decline, decline in metabolic function and other aging conditions. Usually people refer to the phenomenon of irreversible functional decline and gradual death of various organs, tissues and cells in the body as the age increases, which is called the aging of the body. Collective aging has its cellular biological basis. During the aging process, the cells of tissues and organs also experience a gradual decline in morphological structure and physiological functions. With age, the ability of cells to self-renew, proli...

Claims

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Application Information

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IPC IPC(8): C07K5/065C12P21/02C07K1/16A61K38/05A61K36/8967A61P39/06A23L33/00A23L33/135A61K35/745A61K35/747
CPCC07K5/06078C12P21/02A61K36/535A61K36/481A61K36/8967A61K36/41A61K36/638A61K36/258A61K36/16A61K36/534A61K36/62A61K35/745A61K35/747A61P39/06A23L33/00A23L33/135A61K38/00A61K2236/19A23V2002/00A23V2400/513A23V2400/529A61K2300/00A23V2200/302
Inventor 刘志刚刘杰刘晓宇
Owner 刘志刚
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