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Silk fiber reinforced base meniscus composite scaffold with multilayer bionic structure and preparation method thereof

A silk fiber and composite stent technology, applied in the field of biomedical materials, can solve the problem of not being suitable for the mechanical performance requirements of the meniscus stent, and achieve the effects of excellent biocompatibility, improved mechanical performance, and biological requirements.

Active Publication Date: 2021-03-30
NANTONG TEXTILE & SILK IND TECH RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as a SF / WK composite porous material with excellent biocompatibility, but without fiber reinforcement, it is not suitable for the mechanical performance requirements of the meniscal scaffold

Method used

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  • Silk fiber reinforced base meniscus composite scaffold with multilayer bionic structure and preparation method thereof
  • Silk fiber reinforced base meniscus composite scaffold with multilayer bionic structure and preparation method thereof
  • Silk fiber reinforced base meniscus composite scaffold with multilayer bionic structure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] This implementation case shows a silk fiber-reinforced meniscus composite scaffold with a multi-layer bionic structure. see figure 1 , figure 1 It is a structural schematic diagram of a silk fiber-reinforced meniscus composite scaffold with a multi-layer bionic structure according to the present invention. Such as figure 1 As shown, firstly, the raw material of the outer layer 2 is a non-oriented regenerated SF electrospun fiber membrane; the middle layer 3 is a silk short fiber reinforced base SF / WK porous bionic matrix, and the middle layer 3 is provided with radially arranged reinforcing fibers 4; Layer 5 is an oriented regenerated SF electrospun fiber membrane. The preparation sequence is the outer layer 2 (SF electrospinning), then the inner layer 5 (SF electrospinning), and finally stacked together in the order of outer layer 2-intermediate layer 3-inner layer 4 and freeze-dried to prepare a complete meniscal scaffold 1. Specifically include the following step...

Embodiment 2

[0044] Such as figure 1 As shown, this implementation case shows a silk fiber-reinforced meniscus composite scaffold with a multi-layer bionic structure. The meniscus support described in this embodiment is a silk fiber reinforced base meniscus composite support with a multi-layer bionic structure. First, the raw material of the outer layer 2 is non-oriented PLA melted electrospun fiber membrane; the middle layer 3 is a SF / collagen composite porous biomimetic matrix, and the middle layer 3 is provided with radially arranged reinforcing fibers 4; the inner layer 5 is oriented regenerated SF Electrospun fiber membrane. The preparation sequence is the outer layer 2 (PLA electrospinning), then the inner layer 5 (SF electrospinning), and finally in the order of outer layer 2-intermediate layer 3-inner layer 5 by stacking together at -40 to -80 degrees Celsius, 36 The complete meniscal scaffold was prepared by freeze-drying under the condition of ~60h. Specifically include the fo...

Embodiment 3

[0050] Such as figure 1 As shown, this implementation case shows a silk fiber-reinforced meniscus composite scaffold with a multi-layer bionic structure. The meniscus bracket manufactured in this example is a composite bracket of silk fiber reinforced meniscus with a multi-layer bionic structure. First, the raw material of the outer layer 2 is a non-oriented SF / PCL electrospun fiber film; the middle layer 3 is a silk short fiber reinforced base SF / WK porous bionic matrix, and the middle layer 3 is provided with reinforcing fibers 4 arranged radially; the inner layer 5 It is an oriented pure SF aqueous solution electrospun fiber membrane. The preparation sequence is the outer layer 2 (SF / PCL electrospinning), then the inner layer 5 (SF electrospinning), and finally in the order of outer layer 2-intermediate layer 3-inner layer 5 by layering together at -40 to -80 degrees Celsius , freeze-dried under the condition of 36-60h to prepare the complete meniscal scaffold. Specifica...

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Abstract

The invention discloses a silk fiber reinforced base meniscus composite scaffold with a multilayer bionic structure and a preparation method thereof; the silk fiber reinforced base meniscus compositescaffold comprises an outer layer, a middle layer and an inner layer; the outer layer is any one of a non-oriented silk fibroin fiber membrane, a non-oriented polylactic acid melt electrostatic spinning fiber membrane or a silk fibroin / polycaprolactone electrostatic spinning fiber membrane; the middle layer is a silk short fiber reinforced base silk fibroin / wool protein porous bionic matrix or a silk fibroin / collagen composite porous bionic matrix, and reinforcing fibers arranged in the radial direction are arranged in the middle layer; the inner layer is an oriented silk fibroin fiber membrane or an oriented pure silk fibroin aqueous solution electrostatic spinning fiber membrane; and the meniscus scaffold is obtained through freeze drying after sequential stacking and compounding of theouter layer, the middle layer and the inner layer, and the meniscus scaffold has excellent mechanical properties, biocompatibility and tissue regeneration induction capacity.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a silk fiber-reinforced meniscus composite bracket with a multi-layer bionic structure and a preparation method thereof. Background technique [0002] The meniscus is the semilunar cartilage plate between the femoral condyle and the tibial plateau of the knee joint, which belongs to fibrocartilage tissue, including the medial meniscus and the lateral meniscus, surrounded by a relatively small amount of fibrochondrocytes and abundant extracellular matrix Formed, its matrix mainly consists of collagen and proteoglycans. Its function is to reduce the pressure on the knee joint, absorb the shock, buffer the force, maintain the coordination of movement, and lubricate the joint. There are many reasons for meniscus damage, but most of them are caused by torsional external force. Due to the unique anatomical structure of the meniscus and the non-healing ability...

Claims

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Application Information

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IPC IPC(8): B32B9/02A61L27/18A61L27/22A61L27/24A61L27/50A61L27/56D04H1/4326D04H1/435D04H1/541D04H1/728
CPCA61L27/18A61L27/227A61L27/24A61L27/50A61L27/56A61L2430/06B32B9/02D04H1/4326D04H1/435D04H1/541D04H1/728C08L89/00C08L67/04
Inventor 李刚周宇航郑兆柱王晓沁
Owner NANTONG TEXTILE & SILK IND TECH RES INST
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