Periodontal pathogen infection marker detection kit and detection method

A technology for detecting reagents and pathogenic bacteria, applied in the field of biological and medical detection, can solve the problems of lack of guiding significance in the detection of infection markers and formulation of treatment measures, and achieve the effect of preventing the occurrence of AD and preventing the deterioration of the disease.
CN112608976AActive Publication Date: 2021-04-06珠海市德灏生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
珠海市德灏生物科技有限公司
Publication Date
2021-04-06

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Abstract

The invention discloses a periodontal pathogen infection marker detection kit, which comprises a sample eluent, a myeloperoxidase detection reagent and a gingival protease detection reagent, and is characterized in that the sample eluent is an aqueous solution of tris(hydroxymethyl) aminomethane, 3-morpholine propanesulfonic acid, 4-hydroxyethyl piperazine ethanesulfonic acid, piperazine-N, N'-bis (2-ethylsulfonic acid) or 2-(N-morpholine) ethanesulfonic acid; the myeloperoxidase detection reagent comprises oxidase, a substrate corresponding to the oxidase and a color developing agent A, hydrogen peroxide can be generated after the oxidase meets the substrate corresponding to the oxidase, and the color developing agent A comprises a Trinder reaction chromogen substrate; the gingival protease detection reagent is a gingival protease detection reagent I or II, the gingival protease detection reagent I comprises a substrate BAEE, ethanol oxidase and a color developing agent B, and the color developing agent B comprises peroxidase and a Trinder reaction chromogen substrate; and the gingival protease detection reagent II comprises BANA and a diazonium salt color developing agent.
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Description

technical field

[0001] The invention relates to the technical field of biological and medical detection, in particular to a detection kit and a detection method for infection markers of periodontal pathogenic bacteria. Background technique

[0002] Alzheimer's disease (AD) is a degenerative disease of the central nervous system, accounting for 60-70% of senile dementias. The main clinical manifestations are neuropsychiatric symptoms such as progressive memory impairment, cognitive dysfunction, personality changes and language barriers. The characteristic pathological changes are extracellular senile plaques formed by the deposition of β-amyloid protein (Aβ), neurofibrillary tangles (NFTs) in nerve cells formed by hyperphosphorylation of tau protein, and neuron loss with glial cell proliferation.

[0003] The exact etiology and pathogenesis of AD have not yet been fully elucidated, but it is agreed that the occurrence of AD is the result of the joint action of genetic factor...

Claims

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