Preparation method of Xinnaoxin tablets

A heart-brain and centrifugal filtration technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of lycium barbarum decocting operation, low curative effect, long production cycle, etc. , to achieve the effect of improving the decoction efficiency, reducing the extraction yield and increasing the production volume

Pending Publication Date: 2021-04-09
成都晶博生物科技有限责任公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many factors that affect the extraction yield of Xinnaoxin Tablets, such as the extraction methods of Lycium barbarum and Rhodiola rosea, different sources of Lycium barbarum, different apertures and space wrapping of Lycium barbarum, spray drying parameters, etc. The production process of the existing technology is relatively traditional. The production cycle is long, the curative effect is low, and the technology needs to be improved
[0003] And in the processing process of Lycium barbarum, it is found that the production efficiency of the tablet is seriously affected in the production of the tablet. Inner wall adhesion, long-term use will affect the decoction effect of wolfberry, correspondingly also have a greater impact on the quality of the tablet, while the existing decoction device has a greater impact on the decoction operation of wolfberry impact, reducing tablet production efficiency

Method used

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  • Preparation method of Xinnaoxin tablets
  • Preparation method of Xinnaoxin tablets
  • Preparation method of Xinnaoxin tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] (1) Take 800g Rhodiola rosea, add 5 times the amount of 70% ethanol to reflux and extract twice, the first time is 3 hours, the second time is 2 hours, combine the extracts, recover the ethanol and use it for later use;

[0111] (2) Take 400g wolfberry, add 5 times the amount of water to decoct twice, combine the decoction, each time for 2 hours, combine the decoction, and the filtrate for later use;

[0112] (3) 130g of seabuckthorn fresh pulp is mixed with the above-mentioned alcohol extract and water extract, concentrated to 50°C, and a clear paste with a relative density of 1.05~1.10;

[0113] (4) Centrifuge the above clear paste at 2000r / min for 5 minutes, add β-cyclodextrin and appropriate amount of starch accounting for 8% of the clear paste, heat and mix, and spray dry. The spray drying parameters are: air inlet temperature 160°C, The air outlet temperature is 75-85°C, the atomization is 320Hz for atomization, the liquid inlet speed is 10-20Hz, and the heating k...

Embodiment 2

[0143] (1) Take 1200g of Rhodiola rosea, add 15 times the amount of 70% ethanol to reflux and extract twice, the first time is 3 hours, the second time is 2 hours, combine the extracts, and recover the ethanol for later use;

[0144] (2) Take 600 g of wolfberry, add 10 times the amount of water to decoct twice, combine the decoction for 2 hours each time, combine the decoction, and use the filtrate for later use. decoction operation;

[0145] (3) Mix 150g of seabuckthorn fresh pulp with the above-mentioned alcohol extract and water extract, concentrate to 50°C, and make a clear paste with a relative density of 1.05~1.10;

[0146] (4) Centrifuge the clear paste at 4000r / min for 20 minutes, add β-cyclodextrin and an appropriate amount of starch accounting for 30% of the clear paste, heat and mix, and spray dry. The spray drying parameters are: inlet air temperature 160°C, outlet air temperature The air temperature is 75-85℃, the atomization is 320Hz for atomization, the liquid ...

Embodiment 3

[0149] As a preferred embodiment of this application,

[0150] (1) Take 1000g of Rhodiola rosea, add 10 times the amount of 70% ethanol to reflux and extract twice, the first time is 3 hours, the second time is 2 hours, combine the extracts, and recover the ethanol for later use;

[0151] (2) Take 500 g of wolfberry, add 8 times the amount of water to decoct twice, combine the decoction for 2 hours each time, combine the decoction, and use the filtrate for later use. decoction operation;

[0152] (3) Mix 140g of seabuckthorn fresh pulp with the above-mentioned alcohol extract and water extract, concentrate to 50°C, and make a clear paste with a relative density of 1.05~1.10;

[0153] (4) Centrifuge the clear paste at 3000r / min for 10 minutes, add β-cyclodextrin and appropriate amount of starch accounting for 15% of the clear paste, heat and mix, and spray dry. The spray drying parameters are: inlet air temperature 160°C, outlet air temperature The air temperature is 75-85℃, ...

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Abstract

The invention discloses a preparation method of Xinnaoxin tablets. The preparation method comprises the following steps: taking 1000g of rhodiola rosea, adding 10 times of 70% ethanol, carrying out reflux extraction twice, combining the extracting solutions, and recovering ethanol for later use; taking 500g of fructus lycii, adding 8 times of water to decoct twice, combining the decoctions, filtering the decoctions by using a 200-mesh stainless steel screen, and reserving the filtrate for later use; mixing 140 g of fresh sea buckthorn pulp with alcohol extract and water extract, and concentrating the mixture into clear paste with the temperature of 50 DEG C and the relative density of 1.05-1.10; centrifugally filtering the clear paste for 10 minutes at the speed of 3000r / min, adding beta-cyclodextrin accounting for 15% of the amount of the clear paste and a proper amount of starch, and carrying out heating, uniform mixing and spray drying; and adding pvpp and lactose which respectively account for 0.5% of the total quantity of the semi-finished product, adding a proper amount of starch, carrying out uniform mixing and granulating, preparing 1000 tablets, and coating the tablets with film coatings to obtain the Xinnaoxin tablets. The optimal preparation condition is explored through multiple tests, the material atomization effect is relatively good, the materials can be sieved into powder, the materials can be collected normally, tower sweeping is easy, the industrial production efficiency is improved, and the cost is reduced.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method of Xinnaoxin Tablets. Background technique [0002] Clinically, Xinnaoxin Tablets is a Chinese patent medicine preparation mainly made of Lycium barbarum, Rhodiola rosea and seabuckthorn fresh pulp. It has the effects of nourishing qi and nourishing yin, promoting blood circulation and resolving phlegm. , headache, palpitations, asthma, fatigue, polycythemia caused by hypoxia see the above syndrome. There are many factors affecting the extraction yield of Xinnaoxin Tablets, such as the extraction methods of Lycium barbarum and Rhodiola rosea, different sources of Lycium barbarum, different apertures and space wrapping of Lycium barbarum, spray drying parameters, etc. The production process of the existing technology is relatively traditional. The production cycle is longer, the curative effect is lower, and the technology needs to be im...

Claims

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Application Information

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IPC IPC(8): A61K9/30A61J3/00A61K36/815A61P1/08A61P25/00A61P9/06A61P11/00A61P39/00A61K9/14A61K47/40A61K47/36
CPCA61K9/2095A61J3/00A61K36/41A61K36/815A61K36/185A61K9/2059A61K9/2018A61K9/282A61P1/08A61P25/00A61P9/06A61P11/00A61P39/00A61K9/146A61K47/40A61K47/36A61K2300/00
Inventor 王芹胡义新
Owner 成都晶博生物科技有限责任公司
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