Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Traditional Chinese medicine composition for treating insulin resistance of type 2 diabetes mellitus and preparation method and application thereof

A technology for type 2 diabetes and insulin resistance, applied in the field of pharmacy, can solve problems such as deterioration and progression to uremia, and achieve no adverse reactions and reduce podocyte damage.

Pending Publication Date: 2021-04-09
NANJING DRUM TOWER HOSPITAL
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for patients with diabetic kidney damage, once they enter the period of massive proteinuria, their renal function will deteriorate sharply and rapidly progress to uremia

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Traditional Chinese medicine composition for treating insulin resistance of type 2 diabetes mellitus and preparation method and application thereof
  • Traditional Chinese medicine composition for treating insulin resistance of type 2 diabetes mellitus and preparation method and application thereof
  • Traditional Chinese medicine composition for treating insulin resistance of type 2 diabetes mellitus and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of Chinese medicine composition pill of the present invention

[0035] Take 60g of hollyhock flower, 60g of Shiwei, 60g of hedyotis diffusa, 15g of berberine, and 60g of motherwort.

[0036] Take each component and add 8 times the amount of water, 60g of hollyhock flower, 60g of Shiwei, 60g of Hedyotis diffusa, 15g of Coptis chinensis, 60g of Motherwort, decoct and extract 2-3 times, 1-3 hours each time, combine the decoction, Concentrate, heat polyoxyethylene monostearate and glycerol behenate in a water bath, add colloidal silicon dioxide under stirring, continue stirring, slowly add Chinese medicine extract, mix evenly, and obtain a melt. Drop the melt into the simethicone condensate, condense into pills, wash the pills with simethicone, and then wipe off the simethicone on the surface of the pills to prepare pills.

Embodiment 2

[0038] The preparation of Chinese medicine composition tablet of the present invention

[0039] Take 40g of hollyhock flower, 40g of Shiwei, 40g of Hedyotis diffusa, 10g of Coptis chinensis, and 40g of Motherwort.

[0040] Take each component and add 12 times the amount of water, add 40g of hollyhock flower, 40g of Shiwei, 40g of Hedyotis diffusa, 10g of Coptis chinensis, and 40g of motherwort, decoct (the time is the same as above), combine the decoction, concentrate to obtain the extract, and dry , crushed to obtain dry powder, add 1.4 times the amount of dextrin, mix well, add 75% ethanol in an appropriate amount, let it stand for 12-24 hours, filter, recover ethanol from the filtrate, granulate, dry, sieve, and then add flow aid Appropriate amount, compressed into tablets.

Embodiment 3

[0042] The preparation of Chinese medicine composition granule of the present invention

[0043] Take 30g of hollyhock flower, 30g of Shiwei, 30g of hedyotis diffusa, 10g of berberine, and 30g of motherwort.

[0044] Take each component and add 12 times the amount of water, 30g of hollyhock flower, 30g of Shiwei, 30g of Hedyotis diffusa, 10g of Coptis chinensis, 30g of motherwort, decoct (the time is the same as above), combine the decoction, concentrate to obtain the extract, dry, Pulverize to obtain a dry powder, add 1.4 times the amount of dextrin, mix well, add an appropriate amount of 75% ethanol, granulate, dry, and make granules.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a traditional Chinese medicine composition for treating insulin resistance of type 2 diabetes mellitus and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-60 parts of abelmoschus manihot flowers, 15-60 parts of pyrrosia lingua, 15-60 parts of oldenlandia diffusa, 5-15 parts of coptis chinensis and 15-60 parts of leonurus. The traditional Chinese medicine composition disclosed by the invention has the effects of clearing heat and promoting diuresis as well as dispersing blood stasis and dredging collaterals, and is used for treating insulin resistance and microalbuminuria of type 2 diabetes mellitus. Clinical pharmacodynamic tests show that the traditional Chinese medicine composition has a multi-target treatment function on insulin resistance and microalbuminuria of patients suffering from type 2 diabetes mellitus, and is free of adverse reaction in the testing process; in-vivo pharmacological tests show that the traditional Chinese medicine composition is capable of alleviating insulin resistance of diabetes mellitus, improving structures and functions of foot cells and reducing microalbuminuria; and a novel option is provided for clinical treatment on early kidney injury of type 2 diabetes mellitus with refractory proteinuria as characteristics.

Description

technical field [0001] The invention belongs to pharmaceutical technology, and in particular relates to a traditional Chinese medicine composition for treating insulin resistance of type 2 diabetes and its preparation method and application. Background technique [0002] At present, the high incidence of diabetes in my country has become a public health problem that affects national economic and social development and seriously endangers national health. Among them, type 2 diabetic kidney injury is the most common clinical complication and an important cause of diabetes patients progressing to uremia. For this group of people, "refractory proteinuria (including microalbuminuria and overt proteinuria)" is the main clinical feature and intervention target in the early stage of disease. Therefore, "reducing proteinuria" should become a routine means to improve early kidney damage in type 2 diabetes. Studies have shown that the kidney is the target organ of insulin and has abu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/748A61P3/10A61P13/12A61P5/50
CPCA61K36/185A61K36/12A61K36/748A61K36/718A61K36/533A61P3/10A61P13/12A61P5/50A61K2236/331A61K2236/39A61K2236/55A61K2300/00
Inventor 万毅刚涂玥吴薇刘莹露房其军刘不悔王美子
Owner NANJING DRUM TOWER HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com