Preparation method of levofloxacin hydrochloride tablet
A technology for levofloxacin hydrochloride tablets and levofloxacin hydrochloride, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve problems such as poor microbial limit test accuracy and unsatisfactory finished product content.
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[0038] The present invention will be further elaborated below in conjunction with embodiment.
[0039] The invention discloses a levofloxacin hydrochloride tablet. The levofloxacin hydrochloride tablet consists of the following ingredients per 1000 tablets by weight:
[0040] Raw material: levofloxacin hydrochloride 100g, calculated as levofloxacin;
[0041] Filling agent: pregelatinized starch 163.8g, carboxymethyl starch sodium 5g; pregelatinized starch viscosity 5-20cps;
[0042] Adhesive: Povidone K30 4.5g;
[0043] Disintegrant: sodium starch glycolate 5g;
[0044] Lubricants: stearic acid 3.7g, talcum powder 9g.
[0045] The preparation method of above-mentioned levofloxacin hydrochloride tablet is as follows:
[0046] (1) Povidone K30 is mixed with the adhesive solution that mass concentration is 9%, for subsequent use;
[0047] (2) Adopt high-efficiency wet granulator to prepare mixed wet granules, and its parameters are set as follows: stirring low speed setting ...
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