NMN slow-release enteric microcapsule and preparation method thereof

A microcapsule and enteric-coated technology, which is applied in the field of NMN slow-release enteric-coated microcapsules and its preparation, achieves high yield, good product stability, and improved bioavailability

Inactive Publication Date: 2021-04-20
XIAMEN KINGDOMWAY BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the defect that the existing NMN is used in the form of a mixed composition to make it more sensitive to factors such as temperature, light and oxygen, and to provide a new NMN slow-release enteric microcapsule and its preparation method, the yield of this method is high, and the obtained NMN slow-release enteric-coated microcapsules can not only effectively overcome the instability of MNM itself, improve the sensitivity to factors such as temperature, light and oxygen, but also have good slow-release enteric-coated microcapsules. Solubility, can effectively improve the bioavailability of NMN

Method used

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  • NMN slow-release enteric microcapsule and preparation method thereof
  • NMN slow-release enteric microcapsule and preparation method thereof
  • NMN slow-release enteric microcapsule and preparation method thereof

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preparation example Construction

[0053] The present invention also provides a preparation method of NMN slow-release enteric-coated microcapsules, the method comprising:

[0054] S1. Disperse NMN, emulsifier and other oil-soluble components in the auxiliary agent in the carrier oil to form an oil phase mixture, and the oil phase mixture is atomized and adsorbed on the adsorbent to form core particles; the wall material I and The water-soluble components in the wall material II and other additives are dissolved in water to form an aqueous phase solution, which is heated to 40-50°C and kept warm for later use; the wall material I is non-protein carbohydrate and / or vegetable glue wall material, so The wall material II is a wall material having an electric charge opposite to that of the emulsifier, and the other additives are selected from at least one of antioxidants, colorants, sunscreens and food flavors and fragrances;

[0055] S2, mixing the core particles with the aqueous phase solution, shear emulsificatio...

Embodiment 1

[0065] Formula composition

[0066] recipe ingredients Feed amount (weight part) NMN 1 MCT 5 Calcium stearoyl lactylate 0.1 fumed silica 10 Modified starch (Cargill 12670) 40 Maltodextrin 39.9 Chitosan 4

[0067] S1. Uniformly disperse 1 part of NMN pure product and 0.1 part of calcium stearoyl lactylate in 5 parts of carrier oil MCT through a nano grinder to form an oil phase mixture, and atomize the oil phase mixture on 10 parts of fumed silica adsorbent Adsorbed on top to form core particles; dissolve 40 parts of modified starch, 39.9 parts of maltodextrin, and 4 parts of chitosan in 110 parts of pure water at 40-50°C, mix well to prepare an aqueous phase solution, and store at 40-50°C The lower heat preservation spare;

[0068] S2. Mix the core particles and the aqueous solution, and shear for 15 minutes at a speed of 10,000 rpm to obtain a stable NMN emulsion;

[0069] S3. Perform low-temperature electrostatic spr...

Embodiment 2

[0071] Formula composition

[0072] recipe ingredients Feed amount (weight part) NMN 1 MCT 20 Calcium stearoyl lactylate 0.5 fumed silica 20 Modified starch (Cargill 12670) 40 Maltodextrin 14.5 Chitosan 4

[0073] S1. Uniformly disperse 1 part of NMN pure product and 0.5 part of calcium stearoyl lactylate in 20 parts of carrier oil MCT through a nano grinder to form an oil phase mixture, and atomize the oil phase mixture on 20 parts of fumed silica adsorbent Adsorbed on top to form core particles; dissolve 40 parts of modified starch, 14.5 parts of maltodextrin, and 4 parts of chitosan in 110 parts of pure water at 40-50 °C, mix well to prepare an aqueous phase solution, and store at 40-50 °C The lower heat preservation spare;

[0074] S2. Mix the core particles and the aqueous solution, and shear for 15 minutes at a speed of 10,000 rpm to obtain a stable NMN emulsion;

[0075] S3. Perform low-temperature electrostatic...

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Abstract

The invention belongs to the field of NMN application and relates to an NMN slow-release enteric microcapsule and a preparation method thereof. The preparation method of the NMN slow-release enteric microcapsule comprises the following steps: dispersing NMN, an emulsifier and oil-soluble components in other assistants into carrier oil, and atomizing and adsorbing an obtained oil-phase mixture onto an adsorbent to form core particles; dissolving a wall material I, a wall material II and water-soluble components in other assistants into water to form a water-phase solution; and mixing the core particles with the water-phase solution, shearing and emulsifying an obtained mixture, and carrying out low-temperature electrostatic spray-drying on the obtained NMN emulsion to prepare the NMN slow-release enteric microcapsule. The provided method has relatively high yield. Besides, the obtained microcapsule can avoid influences of water, oxygen, light, temperature and the like in an external environment on NMN, improves storage stability, also can further reduce a release rate in the stomach, has a relatively high release rate in the small intestine in a relatively short time, and is beneficial to improving bioavailability.

Description

technical field [0001] The invention belongs to the application field of NMN, and in particular relates to an NMN slow-release enteric-coated microcapsule and a preparation method thereof. Background technique [0002] Nicotinamide mononucleotide (NMN, nicotinamide mononucleotide) is a naturally occurring biologically active nucleotide. NMN exists in two irregular forms, α and β. Among them, the β isomer is the active form of NMN. NMN is the precursor of NAD+, and its function is mainly reflected by NAD+. NAD+, also known as coenzyme I, is the full name of nicotinamide adenine dinucleotide. It is widely distributed in all cells of the human body and participates in thousands of biocatalytic reactions. It is an essential coenzyme in the human body. NAD+ specifically participates in the following reactions: growth, DNA repair (PARPs-mediated), SIRTs protein, and NADP(H) synthesis. NMN is widely distributed in tissues and organs throughout the body, and exists in various ce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/706A61K47/04A61K47/40A61K47/36A61K47/38A61K47/54A61K47/61
Inventor 刘锦洪林木荣王文积王雪瑞
Owner XIAMEN KINGDOMWAY BIOTECH CO LTD
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