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A brushite bone cement and its preparation method and application

A technology of brushite and bone cement, applied in prosthesis, medical science, etc., can solve the problems of decreased injectability, inability to apply clinically, and no major breakthrough in mechanical properties, etc., to achieve good injectability, aspect The effect of clinical operation

Active Publication Date: 2022-04-12
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Over the years, many scholars have reduced the particle size of reactants [Acta Biomater 2009,5(1),43-49], fiber reinforcement [Acta Biomater 2018,79,182-201], or used citric acid [Philos Trans A Math Phys Eng Sci 2010,368,1937-1961] and pyrophosphate [J Am Chem Soc 2005,88(11),3096-3103] and other admixtures to enhance brushite bone cement, but no major breakthrough has been made in its mechanical properties
Moreover, in order to improve the mechanical strength of bone cement, a smaller water-cement ratio is often used, resulting in reduced injectability, which cannot be applied clinically.

Method used

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  • A brushite bone cement and its preparation method and application
  • A brushite bone cement and its preparation method and application
  • A brushite bone cement and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 Preparation and performance of novel brushite bone cement

[0027] In this example, calcium dihydrogen phosphate was used as the acidic calcium source, and β-tricalcium phosphate was used as the basic calcium source. The two raw materials were sieved with a screen of about 50 μm and mixed at a mass ratio of 1:1. After the mixed solid is mixed with 0.3mol / L ammonium acetate solution at a liquid-solid ratio of 1:3 (mass ratio), the curing time is 20 minutes, the compressive strength is 50MPa, and the final product is brushite. The X-ray diffraction pattern of the prepared calcium phosphate bone cement solidification product is as follows figure 1 The scanning electron micrographs of the microscopic morphology are shown in figure 2 shown.

Embodiment 2

[0028] Example 2 High-strength brushite bone cement for load-bearing parts

[0029] In this example, ammonium bicarbonate was added to brushite bone cement as an admixture. The preparation process of the bone cement was the same as in Example 1. Mix a certain concentration of ammonium bicarbonate solution with calcium phosphate raw material (the mass ratio of calcium dihydrogen phosphate to β-tricalcium phosphate is 1:1) according to the liquid-solid ratio of 1:3, and fill the mixed cement slurry into In a cylinder with a diameter of 6 mm and a height of 1 mm, its mechanical strength was tested using a universal mechanical testing machine. The experimental results show that the concentration of ammonium bicarbonate has a significant effect on its mechanical characteristics. When the concentration of ammonium bicarbonate is 0.09mol / L, its compressive strength can reach 75MPa. The specific experimental results are as follows:

[0030] Ammonium bicarbonate concentra...

Embodiment 3

[0031] Example 3 Injectable Brushite Bone Cement for Minimally Invasive Repair

[0032] In this embodiment, polyaspartic acid is added to brushite bone cement as an admixture to enhance its injectability and anti-collapse performance, wherein the mass concentration of polyaspartic acid is 7.5%. The preparation process of brushite bone cement is the same as that in Example 1. Such as image 3 and Figure 4As shown, the bone cement added with polyaspartic acid has good injectability, and its anti-collapse performance has been greatly improved.

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Abstract

The invention discloses a novel brushite bone cement, its preparation and its application in the fields of bone repair and bone regeneration. Brushite bone cement includes: at least one acidic calcium phosphate compound, accounting for 10% to 90% of the total mass of brushite bone cement; at least one basic calcium phosphate compound, accounting for the total mass of brushite bone cement 10% to 90% of the total mass of brushite bone cement; at least one soluble ammonium salt accounts for 10% to 90% of the total mass of brushite bone cement. The brushite bone cement prepared by the present invention has excellent mechanical properties, the highest compressive strength can reach 75MPa, and can be used for bone repair in load-bearing parts; it has controllable curing time, which can be adjusted to 10 according to application requirements. Between minutes and 1; it has good injectability, is convenient for clinical operation, and can be used for minimally invasive treatment of bone injuries.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a novel brushite bone cement, its preparation and its application in the fields of bone repair and bone regeneration. Background technique [0002] Bone cement is widely used clinically in orthopedics. Polymethyl methacrylate [Poly(methylmethacrylate), PMMA] is the earliest developed and most widely used bone cement. In 1996, British doctor Charnley used it for the first time to fix orthopedic implants. It consists of two parts: solid and liquid, and the solid phase includes PMMA powder, initiator, and X-ray blocking agent. The solution includes methyl methacrylate monomer, accelerator and stabilizer. After mixing the two phases, after a certain period of time, it can polymerize and solidify into polymer PMMA by itself. It has excellent mechanical properties and can well restore its load-bearing function when used in stressed parts such as the vertebral body. In addition,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/18A61L27/16A61L27/24A61L27/22A61L27/20A61L27/50C04B12/02
Inventor 陈嵩李斌丁路光
Owner SUZHOU UNIV