Preparation method of regional function specific clinical periodontal defect repair module

A specific and functional technology, applied in medical science, prosthesis, etc., can solve the problems that the barrier film affects the healing effect of periodontal regeneration, cannot restore the physiological function of periodontal tissue, and has limited regeneration effect of periodontal ligament tissue. Reduce technical sensitivity, simplify periodontal regeneration surgery, and improve the effect of vertical increments

Active Publication Date: 2021-04-20
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The shift and collapse of postoperative barrier membrane will affect the healing effect of periodontal regeneration
[0004] In addition, the above two treatment methods have limited effect on inducing periodontal ligament tissue regeneration, and long junctional epithelial healing is still the most common healing method after periodontal surgery.
Long junctional epithelial healing cannot restore the physiological function of the periodontal tissue to withstand the external force of mastication in all directions, and lacks long-term stability. When it is stimulated by repeated inflammation, it is very easy to cause periodontal tissue damage again

Method used

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  • Preparation method of regional function specific clinical periodontal defect repair module
  • Preparation method of regional function specific clinical periodontal defect repair module
  • Preparation method of regional function specific clinical periodontal defect repair module

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0043] Production of regional function-specific clinical periodontal defect repair module

[0044] (1) Preparation of functional domains for alveolar bone regeneration

[0045] A. Synthesis of wollastonite powder doped with magnesium

[0046] Prepare 2.0L of 1M Na 2 SiO 3 Aqueous solution (liquid A), simultaneously prepare 2.0L of Ca(NO 3 ) 2 with Mg(NO 3 ) 2 Mix the solution (molar ratio Ca:Mg=94:6, solution B), stir until the powder is completely dissolved in the solution, and the solution is clear and transparent. Use ammonia water to adjust the pH of solution B to 9.5. Drop liquid B into liquid A at a rate of 2 drops / second, keep stirring and maintain the pH of liquid B with ammonia water. After the dropwise addition was complete, the suspension was continued to be stirred for 24 hours. The reaction suspension was filtered by vacuum filtration, and the obtained white precipitate was washed three times with deionized water and absolute ethanol, and dried in an oven...

Embodiment 2

[0069] Example 2 Production and Application of Regional Function-Specific Clinical Periodontal Defect Repair Module

[0070] (1) Production and application of regional function-specific clinical periodontal defect repair module

[0071] According to the clinical periodontal defect design area function specific clinical periodontal defect repair module, refer to Figure 4 A. Figure 4 B; Divide the prosthetic module into two parts, the lip and buccal side, and the lingual and palatal side to design and manufacture respectively, see Figure 4 C. Figure 4 D. The regional function-specific clinical periodontal defect repair module is composed of alveolar bone regeneration functional domain, periodontal ligament regeneration functional domain and barrier membrane functional domain. The specific design and production process refer to "Example 1".

[0072] The regional function-specific clinical periodontal defect repair module can be used to repair clinical periodontal defects, ...

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Abstract

The invention provides a preparation method of a regional function specific clinical periodontal defect repair module. The module comprises an alveolar bone regeneration functional domain, a periodontal ligament regeneration functional domain and a barrier membrane functional domain. The method comprises the following steps of firstly, carrying out 3D printing on the personalized magnesium-doped wollastonite alveolar bone regeneration functional domain according to clinical alveolar bone defects; and taking MNBG-modified improved PCL / gelatin electrospun membrane as the periodontal ligament regeneration functional domain and Si-HPMC / MA-CMCS hydrogel formed by photocuring as the barrier membrane functional domain, and integrating the alveolar bone regeneration functional domain, the periodontal ligament regeneration functional domain and the barrier membrane functional domain. Imitation periodontal fiber guide structure design and MNBG modification of the periodontal ligament regeneration functional domain provide guidance and support for secretion and integration of collagen matrixes, and MNBG modification can induce proliferation and vertical migration of periodontal ligament fibroblasts, so that vertical increment of periodontal ligament tissue in a defect area is improved, the regeneration of a periodontal tissue complex is promoted, the determinacy of periodontal tissue regeneration is improved, and the technical sensitivity of a periodontal regeneration operation is reduced.

Description

technical field [0001] The invention belongs to the field of dental restoration materials, and relates to a preparation method of a regional function-specific clinical periodontal defect restoration module. Background technique [0002] Periodontitis is one of the most common oral diseases, which can cause progressive and irreversible destruction of periodontal supporting tissues such as gums, alveolar bone, periodontal ligament, and cementum, leading to gingival swelling and bleeding, gingival recession, and alveolar bone resorption , loose teeth shift, and even tooth loss. At present, periodontitis has become the primary cause and main cause of adult tooth loss in my country and even in the world. The ideal periodontitis treatment is not only to remove the etiology and risk factors to eliminate inflammation and control the development of the disease; more importantly, it is to repair and rebuild the damaged periodontal tissue structure, that is, to achieve periodontal tis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/20A61L27/02A61L27/10A61L27/18A61L27/50A61L27/58
Inventor 雷利红韦应明韩佳吟蒋晓健陈莉丽孙伟莲
Owner ZHEJIANG UNIV
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