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Hyaluronic acid modified FeCo bimetal synergistic monatomic catalyst as well as preparation method and application thereof

A hyaluronic acid modification, bimetallic synergy technology, applied in the field of medical materials, can solve the problems of low selectivity, low catalytic efficiency, poor activity and so on

Pending Publication Date: 2021-04-20
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention proposes a hyaluronic acid-modified FeCo bimetallic synergistic single-atom catalyst and its preparation method and application, which solves the problems of low catalytic efficiency, poor activity and low selectivity in current nanocatalytic medicine, and overcomes the toxicity of metal elements problems, maximize the utilization of atoms, and at the same time solve the problems in the application of single-atom catalysts in the biomedical field

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  • Hyaluronic acid modified FeCo bimetal synergistic monatomic catalyst as well as preparation method and application thereof
  • Hyaluronic acid modified FeCo bimetal synergistic monatomic catalyst as well as preparation method and application thereof
  • Hyaluronic acid modified FeCo bimetal synergistic monatomic catalyst as well as preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The preparation method of the hyaluronic acid-modified FeCo bimetallic synergistic single-atom catalyst, the steps are:

[0042] S1. According to Zn(NO 3 ) 2 ·6H 2 O0.8g, Co(NO 3 ) 2 ·6H 2 O0.03g, Fe(acac) 3 0.3g, dissolved in methanol; the mass of 2-methylimidazole is 1.8g, dissolved in methanol, poured into the precursor solution, vigorously stirred at 30°C for 12h;

[0043] S2. Centrifuge 10000rpm of the solution obtained in step S1 for 10 min, repeat 3 times, and dry, and the obtained solid is FeCo co-doped ZIF-8;

[0044] S3. Activate the FeCo co-doped ZIF-8 at 50°C for 12 h;

[0045] S4. Redisperse the solid obtained in step S3 into 60ml of methanol, and ultrasonically disperse at 20°C for 10min;

[0046] S5. adding 60ml ultrapure water to the solid dispersion obtained in step S4, adding 2ml concentration is 10mg / ml hexadecyltrimethylammonium bromide dispersion, then adding 5ml 2mg / ml sodium hydroxide aqueous solution, then adding 0.5 ml of tetraethyl ort...

Embodiment 2

[0054] The preparation method of the hyaluronic acid-modified FeCo bimetallic synergistic single-atom catalyst, the steps are:

[0055] S1. According to Zn(NO 3 ) 2 •6H 2 O2.4g, Co(NO 3 ) 2 •6H 2 O 1.4g, Fe(acac) 3 1.4g, dissolved in methanol; the mass of 2-methylimidazole is 7.6g, dissolved in methanol, poured into the precursor solution, and vigorously stirred at 30°C for 48h;

[0056] S2. 15000rpm of the solution obtained in step S1, centrifuged for 30 min, repeated 3 times, dried, and the obtained solid was FeCo co-doped ZIF-8;

[0057] S3. Activate the FeCo co-doped ZIF-8 at 300°C for 48 h;

[0058] S4. The solid obtained in step S3 was redispersed in 180ml of methanol, and ultrasonically dispersed at 50°C for 60min;

[0059] S5. adding 180ml ultrapure water to the solid dispersion obtained in step S4, adding 10ml concentration is 50mg / ml cetyltrimethylammonium bromide dispersion, then adding 20ml 12mg / ml sodium hydroxide aqueous solution, then adding Dissolve 3 m...

Embodiment 3

[0067] Preparation of FeCo bimetallic synergistic single-atom catalysts

[0068] 1. Preparation of FeCo co-doped ZIF-8

[0069] S1. According to Zn(NO 3 ) 2 ·6H 2 O1.601g, Co(NO 3 ) 2 ·6H 2 O0.783g, Fe(acac) 3 0.7g, dissolved in methanol. The mass of 2-methylimidazole is 3.7g, dissolved in methanol, poured into the precursor solution, and vigorously stirred at 30°C for 24h;

[0070] S2. Centrifuge 12000rpm of the solution obtained in step S1 for 20 min, repeat 3 times, and dry, and the obtained solid is FeCo co-doped ZIF-8;

[0071] 2. SiO2 x Preparation of wrapped FeCo co-doped ZIF-8

[0072] S1. Activate FeCo co-doped ZIF-8 at 50-300°C for 24h;

[0073] S2. Redisperse the solid obtained in step S1 into 120ml of methanol, and ultrasonically disperse at 30°C for 30min;

[0074] S3. adding 120ml ultrapure water to the solid dispersion obtained in step S2, adding 6ml concentration is 25mg / ml hexadecyltrimethylammonium bromide dispersion, then adding 10ml concentratio...

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Abstract

The invention belongs to the technical field of medical materials, and relates to preparation of drugs for catalytic treatment of tumors, in particular to a hyaluronic acid modified FeCo bimetal synergistic monatomic catalyst as well as a preparation method and application of the hyaluronic acid modified FeCo bimetal synergistic monatomic catalyst. The hyaluronic acid modified FeCo bimetal synergistic monatomic catalyst is prepared by the following steps: firstly, synthesizing a FeCo bimetal synergistic monatomic catalyst; the FeCo bimetal synergistic monatomic catalyst can play a synergistic role, so that the catalytic efficiency is remarkably improved. By adopting the hyaluronic acid coated FeCo bimetal synergistic monatomic catalyst, the antitumor activity is remarkably improved and the toxicity to normal tissues is effectively avoided while the catalytic activity is not influenced and the water solubility is increased, so that the biomedical application of the FeCo bimetal synergistic monatomic catalyst is expanded, efficient catalytic tumor treatment is realized, great potential and prospects are realized in the aspect of tumor treatment application.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and relates to the preparation of catalyzed drugs for treating tumors, in particular to a hyaluronic acid-modified FeCo bimetallic synergistic single-atom catalyst and its preparation method and application. Background technique [0002] According to the 2018 Global Cancer Statistics, there were 18.1 million new cancer cases and 9.6 million cancer deaths in 2018. Cancer morbidity and mortality are increasing rapidly worldwide. Cancer is still a major disease threatening human health. At present, the main treatment methods for cancer are still surgery, chemical drug therapy (chemotherapy) and radiation therapy (radiotherapy). Surgical treatment is a local treatment method, which is mainly aimed at the local excision of early tumors with clear boundaries, while the treatment effect on advanced tumors is limited. Chemotherapy and radiotherapy are systemic treatments, which can harm norm...

Claims

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Application Information

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IPC IPC(8): B01J23/75B01J31/06B01J35/00B01J37/00B01J37/08A61K33/26A61K47/36A61P35/00
Inventor 赵永星赵孟阳陈德良杨芮庚魏月茹
Owner ZHENGZHOU UNIV
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