Application of apelin protein in preparation of reagents for diagnosing respiratory diseases

Abstract

The invention discloses the application of Apelin protein in preparing reagents for diagnosing respiratory system diseases. The present invention is the first discovery that Apelin-13, especially the combination of Apelin-13, GP73 (Golgi apparatus transmembrane glycoprotein) and Cys-C (cystatin C) can be used as a diagnosis of respiratory diseases, especially the diagnosis of acute lung injury Markers can effectively improve the detection specificity of acute lung injury.

Description

Technical field [0001] The invention belongs to the field of medical detection, in particular the application of Apelin protein in the preparation of diagnosed respiratory disease reagents. Background technique [0002] Respiratory diseases are common diseases, multi-pathogenesis, main lesions in tracheal, bronchi, lungs, and chest, sorcerer, chest pain, respiratory affected, severe breathing, hypoxia, even respiratory failure. The mortality rate in the city accounts for the third place, while in the countryside. More attention is to pay attention to atmospheric pollution, smoking, population aging and other factors, so that the chronic obstructive pulmonary disease at home and abroad (referred to as chronic bronchitis, emphysema, pulmonary heart disease), bronchial asthma, lung cancer, Pulmonary diffuse measuring fibrosis, as well as the incidence of diseases such as pulmonary infection, and the mortality increases. [0003] According to the statistics of the death of some of th...

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Problems solved by technology

[0005] Although after nearly half a century of research, people have a deep understanding of the pathogenesis, pathophysiology, diagnosis and treatment of acute lung injury, but the mechanism of acute lung injury is very complex, involving infection, inflammation, immunity and tissue Most of the patients are already in the severe stage of acute lung injury when they see a doctor, which is very difficult in the clinical diagnosis and treatment. is less than 30 times / min), its oxygenation index is generally between 200-300mmHg, the body is not seriously hypoxic, and can basically meet the normal needs of organ functions or the body's various organ functions are in the compensatory period. The symptoms of patients in this stage are not typical, which are often ignored by clinicians. If they cannot be effectively identified and effective intervention measures are taken, patients tend to develop in a more serious direction and develop into the stage of ARDS with typical symptoms. serious, the mortality rate increased significantly

At present, there is still no effective method for early identification of acute lung injury and reduction of mortality in clinical practice

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