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A kind of Shanzhuang Jiangzhi pellets and preparation method thereof

A pellet and lipid-lowering technology, which is applied in Shanzhuang Jiangzhi pellets and its preparation field, can solve the problems of long disintegration time, low availability of active ingredients of drugs, volatilization and decomposition of active ingredients of drugs, etc., so as to avoid reaction and shorten Effect of disintegration time and improvement of utilization rate

Active Publication Date: 2021-11-19
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing Shanzhuang Jiangzhi tablets are sugar-coated tablets, which have disadvantages such as long disintegration time and low availability of active ingredients of the drug.
In addition, when preparing the existing Shanzhuang Jiangzhi Tablets, add water to decoct cassia seeds, hawthorn, and lotus leaves to extract active ingredients. The temperature during decoction is high, which will cause the active ingredients of some drugs to volatilize and decompose.

Method used

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  • A kind of Shanzhuang Jiangzhi pellets and preparation method thereof
  • A kind of Shanzhuang Jiangzhi pellets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A preparation method of Shanzhuang lipid-lowering pellets, comprising the following steps:

[0024] R1. Respectively select cassia seed, hawthorn and lotus leaf, cleanly select and dry;

[0025] R2. Weigh the components according to the following weight: 1240g cassia seed, 620g hawthorn, 420g lotus leaf, 150g dextrin, 20g sucrose, 15g konjac gum, 18g hydroxypropyl methylcellulose;

[0026] R3. Semen cassia and lotus leaves were crushed separately, soaked in 80v / v% ethanol aqueous solution A for 40min, the amount used was 8 times the total weight of cassia seeds and lotus leaves, ultrasonically extracted for 45min, filtered, ethanol was recovered from the extract, and concentrated to a thick paste;

[0027] R4. Crush hawthorn, mix with 1-butyl-3-methylimidazole acetate 1.3 times the weight of hawthorn, ultrasonically extract at 55°C for 45 minutes, concentrate and dry the filtrate, add 50v / v% ethanol aqueous solution B to dissolve, and use an amount of hawthorn 4 times ...

Embodiment 2

[0033] A preparation method of mountain villa lipid-lowering pellets, comprising the following steps:

[0034] R1. Respectively select cassia seed, hawthorn and lotus leaf, cleanly select and dry;

[0035] R2. Weigh the components according to the following weight: 1240g cassia seed, 620g hawthorn, 420g lotus leaf, 260g dextrin, 30g sucrose, 26g konjac gum, 23g hydroxypropyl methylcellulose;

[0036] R3. Cassiae seeds and lotus leaves were crushed separately, soaked in 70v / v% ethanol aqueous solution A for 100min, the amount used was 9 times the total weight of cassia seeds and lotus leaves, ultrasonically extracted for 65min, filtered, ethanol was recovered from the extract, and concentrated to a thick paste;

[0037] R4. Crush hawthorn, mix with 1-butyl-3-methylimidazole acetate 1.5 times the weight of hawthorn, ultrasonically extract at 50°C for 60 minutes, concentrate and dry the filtrate, add 58v / v% ethanol aqueous solution B to dissolve, and use an amount of hawthorn 6 ...

Embodiment 3

[0043] A preparation method of Shanzhuang lipid-lowering pellets, comprising the following steps:

[0044] R1. Respectively select cassia seed, hawthorn and lotus leaf, cleanly select and dry;

[0045] R2. Weigh the components according to the following weight: 1240g cassia seed, 620g hawthorn, 420g lotus leaf, 320g dextrin, 36g sucrose, 32g konjac gum, 25g hydroxypropyl methylcellulose;

[0046] R3. Semen cassia and lotus leaves were crushed separately, soaked in 70v / v% ethanol aqueous solution A for 120min, the amount used was 10 times the total weight of cassia seeds and lotus leaves, ultrasonically extracted for 90min, filtered, ethanol was recovered from the extract, and concentrated to a thick paste;

[0047] R4. Hawthorn is crushed and mixed with an ionic liquid of 1.5 times the weight of hawthorn. The ionic liquid is composed of 1-butyl-3-methylimidazole acetate and 1-enbutyl-3-methylimidazolium chloride in a ratio of 1:1 Composition: Ultrasonic extraction at 60°C for...

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Abstract

The invention discloses a Shanzhuang Jiangzhi pellet and a preparation method thereof. The pellet is made of the following raw materials in parts by weight: 1240 parts of cassia seed, 620 parts of hawthorn, 420 parts of lotus leaf, 150-320 parts of dextrin, and 20-20 parts of sucrose 36 parts, 15-32 parts of konjac gum, 18-25 parts of hydroxypropyl methylcellulose. The content of active ingredients in the Shanzhuang Jiangzhi pellets prepared by the process of the present invention is relatively high, chrysophanol, orange cassiatin; the active ingredient of lotus leaf is nuciferine, which is a kind of alkaloid, and it is extracted separately from hawthorn to avoid possible The reaction with acid can improve the active ingredients of the pellets; the hawthorn is extracted with ionic liquid, which can make the flavonoids in the hawthorn more fully extracted; the use of pellets can shorten the disintegration time of the drug in the human body and improve the efficacy of the drug. utilization rate.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to Shanzhuang Jiangzhi pellets and a preparation method thereof. Background technique [0002] Shanzhuang Jiangzhi Tablets are composed of cassia seed, hawthorn, lotus leaf and other three herbs. It is used for hypertension and hyperlipidemia caused by phlegm turbidity and stasis, and has a certain effect on the prevention of atherosclerosis. The active ingredients of Cassia Cassiae, the king drug in the recipe, are anthraquinone compounds, of which chrysophanol and arurinaceous cassiatin are relatively high in content. The existing Shanzhuang Jiangzhi tablets are sugar-coated tablets, which have the disadvantages of long disintegration time and low availability of active ingredients of the medicine. In addition, when the existing Shanzhuang Jiangzhi Tablets are prepared, water is added to decoct cassia seeds, hawthorn, and lotus leaves to extract active in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/734A61K47/36A61P3/06A61K9/50A61K47/38A61K36/482A61K36/62
CPCA61K36/482A61K36/734A61K36/62A61K9/5042A61K9/5036A61K47/36A61P3/06A61K2236/333A61K2300/00
Inventor 刘景萍刘全国陈克领王家李党
Owner HAINAN HULUWA PHARMA GRP CO LTD
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