Novel injection puncture needle and tumor light biopsy technology thereof

Abstract

The invention relates to a novel injection puncture needle and a tumor light biopsy technology thereof. The novel injection puncture needle comprises a micro puncture needle, a hose, a micropipettor, an optical nano probe, a micromanipulation platform and a fluorescence imaging system. The novel puncture needle is formed by combining a miniature puncture needle, a hose, a micropipettor and a micromanipulation platform, and after the novel puncture needle sucks and quantitatively modifies an optical nano probe capable of specifically recognizing tumor cells through the micropipettor, the micromanipulation platform controls the miniature puncture needle to accurately move and directly pierce a target tissue area, the quantitative optical nano probe in the micropipettor is injected into the target area, and the target tumor is specifically connected with the optical nano probe. The fluorescence imaging system performs fluorescence imaging on the target area to judge whether the target area has a lesion or not and judge the lesion area. The method has the characteristics of small wound surface and high detection efficiency. The product is small in size, light in weight, convenient to carry and wide in application. The product is suitable for sampling and inspection in different places and remote areas.

Description

technical field [0001] The invention belongs to the field of optical biological imaging, and relates to a novel injection puncture needle and its optical tumor biopsy technology. Background technique [0002] Puncture is a commonly used biopsy method, which has the advantages of low invasiveness, small wound, and the ability to directly remove secretions for pathological examination. However, follow-up pathological diagnosis based on needle biopsy usually takes a long time and is difficult to perform intraoperatively. [0003] Optical biopsy refers to the technique of obtaining information related to tissue status in vivo or ex vivo by analyzing the interaction between light and tissue by means of optical inspection. Therefore, optical biopsy can provide a real-time, accurate and Objective advanced biopsy method. Optical biopsy is based on the optical properties of different tissues in the human body to identify and diagnose different physiological states of the tissue or ...

AI Technical Summary

Problems solved by technology

In the traditional in vivo fluorescence imaging process, optical nanoprobes are generally injected into the body through intravenous injection, and the probe particles mainly act synergistically on the tumor through passive targeting dominated by the EPR effect and active targeting dominated by specific targeting modifications. Accumulated at the tissue and endocytized by cancer cells, so it takes a long time for blood circulation to detect the fluorescent signal at the tumor site

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