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Probiotic microcapsule and preparation method thereof

A technology of probiotics and capsule cores, applied in the field of probiotic microcapsules and their preparation, can solve the problems of unsuitability for expanded production, low efficiency of extrusion method, large particle size of microcapsules, etc., and achieves controllable particle size and short usage time. , the effect of stable quality

Pending Publication Date: 2021-06-04
SHAOXING TONGCHUANG BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Various current preparation processes have certain limitations, such as the low efficiency of the extrusion method and the large particle size of the microcapsules; the emulsification method requires the use of a large amount of oil, and the separation is difficult and the steps are cumbersome; the spray drying method will cause a large number of viable bacteria death, are not suitable for expanding production

Method used

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  • Probiotic microcapsule and preparation method thereof
  • Probiotic microcapsule and preparation method thereof
  • Probiotic microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. Preparation of Lactobacillus salivarius Li01 microcapsules:

[0039] (1) Preparation of Lactobacillus freeze-dried powder: adopt existing technology, cultivate Lactobacillus by means of fermenter, and carry out freeze-drying, obtain Lactobacillus salivarius Li01 freeze-dried powder, wherein the number of viable bacteria of Li01 is greater than 10 11 CFU / g.

[0040] (2) Configuration of probiotic microcapsule material: Weigh 1 g of Li01 probiotic freeze-dried powder, 40 g of microcrystalline cellulose and 10 g of starch to prepare material A.

[0041] Weigh 1g of HPMC and add 50mL of warm water above 60°C to mix evenly to make solution B with a concentration of 0.2g / mL, and wait for B to cool down to room temperature. Pour the mixed powder A into the tray, and pour solution B several times, adding 25mL in total. well mixed. This step and the following preparation process all need to be completed in a clean room (cleanliness is 10,000 grades).

[0042] (3) Preparat...

Embodiment 2

[0064] 1. Preparation of Lactobacillus salivarius Li05 microcapsules:

[0065] (1) Preparation of Lactobacillus salivarius freeze-dried powder: adopt existing technology, cultivate Lactobacillus salivarius Li05 by means of a fermenter, and carry out freeze-drying, obtain 100g freeze-dried powder, wherein Pediococcus pentosaceae Li05 viable count is greater than 10 11 CFU / g.

[0066] (2) Configuration of probiotic microcapsule material: Weigh 2 g of Li05 probiotic freeze-dried powder, 80 g of microcrystalline cellulose and 20 g of starch to prepare material A.

[0067] Weigh 1 g of HPMC and add 50 mL of warm water above 60°C to mix evenly to make solution B with a concentration of 2 g / mL, and wait until B drops to room temperature. Pour the mixed powder A into the tray, and pour solution B several times, adding a total of 52mL. well mixed. This step and the following preparation process all need to be completed in a clean room (cleanliness is 10,000 grades).

[0068] (3) Pr...

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Abstract

The invention provides a probiotic microcapsule and a preparation method thereof, and relates to the technical field of probiotic products. The method comprises the following steps: (a) preparation of a probiotic-loaded capsule core: mixing capsule core materials including probiotic powder, microcrystalline cellulose and starch, adding a hydroxypropyl methyl cellulose solution, and uniformly mixing; preparing the obtained mixed material into a spherical particle capsule core by adopting an extrusion-spheronization method; and (b) atomizing and coating: performing single-layer or multi-layer coating on the capsule core by using the coating material solution in an atomizing manner to prepare a core-shell type microcapsule. The probiotic microcapsule is large in entrapment capacity, uniform in micro-capsule particles and controllable in particle size; is resistant to storage, targets intestinal tracts, resists gastric acid and has high-temperature stability.

Description

technical field [0001] The invention relates to the technical field of probiotic products, in particular to a probiotic microcapsule and a preparation method thereof. Background technique [0002] Probiotics are microorganisms that have beneficial effects on the intestinal tract. The "Scientific Consensus on Probiotics" points out: "The core characteristics of probiotics are sufficient quantity, viable state and health-promoting functions". "Live bacteria" is a prerequisite for probiotics to be effective, but probiotics are very sensitive to environmental conditions. Not only are the bacteria easily oxidized, but they are also easily oxidized after being ingested through the complex upper gastrointestinal environment containing gastric acid and bile salts. Inactivate. [0003] The use of microencapsulated probiotics is one of the most effective methods at home and abroad to increase the survival rate of live bacteria. Various current preparation processes have certain limi...

Claims

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Application Information

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IPC IPC(8): A23L33/135A23L29/30A23P10/30A23P20/18
CPCA23L33/135A23L29/30A23P20/18A23P10/30A23V2002/00A23V2400/145A23V2400/151A23V2400/147A23V2400/125A23V2400/123A23V2400/181A23V2400/173A23V2400/113A23V2400/175A23V2400/321A23V2400/169A23V2400/513A23V2400/515A23V2400/529A23V2400/517A23V2400/519A23V2400/249A23V2400/533A23V2200/3204A23V2250/51084A61K2035/115A23L29/262A23L29/275A61K35/747A23L29/212A61K35/745A61K35/741A61K9/5073A61K9/4808A61K9/4866A61K9/5036A61K9/5089
Inventor 姚铭飞韩圣逸金欣黄卫新谢娇娇陆艳蒙王波娜高岭俞赤慧李兰娟
Owner SHAOXING TONGCHUANG BIOTECHNOLOGY CO LTD
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