Bacterial cellulose membrane, breast patch thereof and preparation method

A technology of bacterial cellulose membrane and patch, applied in the field of medical biomaterials, can solve the problem that cells cannot grow ideally on it, and achieve the effect of helping breast repair, wide source and good fixation

Active Publication Date: 2021-06-04
NKD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The existing bacterial cellulose membrane, as a biofilm with good mechanical properties, has no immunogenicity in the process of being applied to the human body, but when it is applied to the breast patch, the cells cannot grow ideally on it, so it is urgently needed A bacterial cellulose membrane that can be used as a breast patch, and use it as a base material to develop breast patches with better performance to meet clinical needs

Method used

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  • Bacterial cellulose membrane, breast patch thereof and preparation method
  • Bacterial cellulose membrane, breast patch thereof and preparation method
  • Bacterial cellulose membrane, breast patch thereof and preparation method

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preparation example Construction

[0037] Aiming at the problems existing in the breast patch in the prior art, the present invention firstly provides a bacterial cellulose film for preparing the breast patch, the preparation method of the bacterial cellulose film comprises the following steps: preparing the bacterial fiber by rotary fermentation For plain film, during the fermentation process, macromolecular substances with a particle size of 10-500 μm are sprayed on the bacterial cellulose film, so that the macromolecular substances are distributed in the bacterial cellulose film.

[0038] The bacterial cellulose membrane has good compatibility with the human body, but the pore size of the surface of the bacterial cellulose membrane prepared by the existing method is usually micron, and cells cannot grow ideally on the surface. Adding the above-mentioned substances in the process of the plain film is conducive to the formation of certain gaps between the bacterial cellulose films of different layers, which is ...

Embodiment 1

[0068] This embodiment relates to a preparation method of a breast patch, comprising the following steps:

[0069] 1) to the rotary fermenter (the schematic diagram of its structure is as follows figure 1 ) in the tank body 1, until its height is flush with the surface of the bacterial cellulose membrane forming frame 2; the formula of the fermentation medium is that every 500mL contains: glucose 15g, maltose 10g, peptone 2.5g , 2.5g of yeast extract, 0.5g of citric acid, 1g of disodium hydrogen phosphate, 0.5g of dipotassium hydrogen phosphate and the rest of distilled water;

[0070] 2) Activating Acetobacter xylinum producing cellulose film to obtain activated strains, expanding the culture of the activated strains to obtain seed liquid, inoculating the seed liquid into fermentation medium and fermenting to obtain bacterial cellulose fermentation liquid, and fermenting for 5 days Afterwards, the bacterial cellulose film is formed on the surface of the bacterial cellulose f...

Embodiment 2

[0083] This embodiment relates to a preparation method of a breast patch, comprising the following steps:

[0084] 1) to the rotary fermenter (the schematic diagram of its structure is as follows figure 1 ) to add fermentation medium until its height is flush with the surface of the frame formed by the bacterial cellulose membrane; the formula of the fermentation medium is that every 500mL contains: glucose 20g, maltose 15g, peptone 2.5g, yeast extract 2.5g , citric acid 0.5g, disodium hydrogen phosphate 1g, dipotassium hydrogen phosphate 0.5g and the remainder of distilled water;

[0085] 2) Activating Acetobacter xylinum producing cellulose film to obtain activated strains, expanding the culture of the activated strains to obtain seed liquid, inoculating the seed liquid into fermentation medium and fermenting to obtain bacterial cellulose fermentation liquid, and fermenting for 6 days Afterwards, the bacterial cellulose film is formed on the surface of the bacterial cellulo...

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Abstract

The invention belongs to the technical field of medical biomaterials, and particularly relates to a bacterial cellulose membrane, a breast patch thereof and a preparation method. The preparation method of the bacterial cellulose membrane comprises the following steps that the bacterial cellulose membrane is prepared in a rotary fermentation mode, and macromolecular substances with the particle size of 10-500 microns are sprayed to the bacterial cellulose membrane in the fermentation process, so that the macromolecular substances are distributed in the bacterial cellulose membrane. The breast patch prepared from the bacterial cellulose membrane has no immunogenicity, has good compatibility with the human body, has good mechanical properties, meets the clinical suture strength requirement, can well fix a breast prosthesis and is beneficial to breast repair.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and in particular relates to a bacterial cellulose membrane, a breast patch and a preparation method thereof. Background technique [0002] Breast cancer is the most common malignant tumor among women all over the world, and nearly half of the women will choose to have their breasts removed during treatment. However, mastectomy will bring huge psychological pressure to the patients' normal life, so many people will choose to have breast cancer Repair and rebuild. In the process of breast reconstruction, because there are many original defects, the implantation of the prosthesis can easily lead to the displacement of the prosthesis, which requires a biological patch for fixed repair, and reduces related complications such as cysts. [0003] In response to this problem, breast patches currently on the market are divided into artificial synthetic material patches and biological materia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P19/04A61F2/00
CPCC12P19/04A61F2/0063A61F2/0059
Inventor 石凌锋张璋刘廷薇陶秀梅
Owner NKD PHARMA CO LTD
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