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Dexibuprofen injection

A technology of dextro-ibuprofen and injection, applied in the field of pharmaceutical preparations, can solve problems such as no reference value, hinder scientific research, etc., and achieve the effects of ensuring therapeutic activity, improving safety, and reducing risks

Active Publication Date: 2021-06-15
BEIJING JIACHENG MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Chinese patent review CN104546697A discloses a dextroibuprofen injection pharmaceutical composition and a preparation method thereof. In this application, it is believed that a smaller dose of dexibuprofen is used through a large number of tests and researches, i.e. It can achieve the same drug effect as the existing Dexibuprofen injection, which further discloses that every milliliter of injection contains 15-75mg Dexibuprofen, and enumerates a large number of examples for disclosure, but these examples What is the efficacy of the drug, what is the basis for the content of dexibuprofen in such an injection, and how is it equivalent to racemic ibuprofen? and has the adverse effect of hampering further research

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: formula and production process of unit preparation Dexibuprofen injection

[0038] Table 1: 1000ml Product Product Recipe Composition

[0039] ingredients Dosage Excessive addition effect Executive standard Dexibuprofen 100g none Main drug Chinese Pharmacopoeia 2020 Edition Part II and Internal Control Standards arginine 82g none Co-solvent Chinese Pharmacopoeia 2020 Edition Volume II medicinal charcoal 1g none Adsorbent Chinese Pharmacopoeia 2020 Edition Four Volumes NaOH Appropriate amount none pH regulator Chinese Pharmacopoeia 2020 Edition Four Volumes HCL Appropriate amount none pH regulator Chinese Pharmacopoeia 2020 Edition Four Volumes Water for Injection Appropriate amount none solvent Chinese Pharmacopoeia 2020 Edition Four Volumes

[0040] The process description is as follows:

[0041] 1) Weigh arginine according to the prescription amount, add it to...

Embodiment 2

[0048] Embodiment 2: 125mg unit preparation Dexibuprofen injection formula and production process

[0049] Table 2: Composition of 125mg unit formulation product formulation

[0050] ingredients Dosage Excessive addition effect Executive standard Dexibuprofen 125mg none Main drug Chinese Pharmacopoeia 2020 Edition Part II and Internal Control Standards arginine 100mg none Co-solvent Chinese Pharmacopoeia 2020 Edition Volume II medicinal charcoal 1.25mg none Adsorbent Chinese Pharmacopoeia 2020 Edition Four Volumes NaOH Appropriate amount none pH regulator Chinese Pharmacopoeia 2020 Edition Four Volumes HCL Appropriate amount none pH regulator Chinese Pharmacopoeia 2020 Edition Four Volumes Water for Injection Appropriate amount none solvent Chinese Pharmacopoeia 2020 Edition Four Volumes

[0051] 1) Weigh arginine according to the prescription amount of 1000 unit doses, add it to ...

Embodiment 3

[0058] Embodiment 3: 200mg unit preparation Dexibuprofen injection formula and production process

[0059] Table 3: 200mg unit formulation product formulation composition

[0060] ingredients Dosage Excessive addition effect Executive standard Dexibuprofen 200mg none Main drug Chinese Pharmacopoeia 2020 Edition Part II and Internal Control Standards arginine 172mg none Co-solvent Chinese Pharmacopoeia 2020 Edition Volume II medicinal charcoal 2mg none Adsorbent Chinese Pharmacopoeia 2020 Edition Four Volumes NaOH Appropriate amount none pH regulator Chinese Pharmacopoeia 2020 Edition Four Volumes HCL Appropriate amount none pH regulator Chinese Pharmacopoeia 2020 Edition Four Volumes Water for Injection Appropriate amount none solvent Chinese Pharmacopoeia 2020 Edition Four Volumes

[0061] Production technology is the same as embodiment 2

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Abstract

The invention provides a dexibuprofen injection. Compared with a corresponding racemic ibuprofen injection, the dexibuprofen injection has the advantages of improved biological activity, stable blood concentration and reduced side effects.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a pharmaceutical preparation of Dexibuprofen. Background technique [0002] Ibuprofen is a propionic acid non-steroidal anti-inflammatory drug commonly used in clinic. It has stronger anti-inflammatory, analgesic and antipyretic effects than aspirin. It is widely used clinically for various headaches, migraines, rheumatism, muscle pain, back Pain, neuralgia, dysmenorrhea, toothache, and pain and fever symptoms of colds and colds, or pain agents for various types of rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, postoperative pain, postpartum pain, and soft tissue damage. disease etc. At present, it has been widely used in the world and has become one of the best-selling over-the-counter drugs in the world. It is listed as the three pillar products of antipyretic and analgesic drugs together with aspirin and paracetamol. [0003] Although ibuprofen is considered the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/192A61K47/18A61P29/00A61P25/06A61P25/00A61P1/02A61P15/00A61P21/00A61P19/02
CPCA61K9/08A61K9/0019A61K31/192A61K47/183A61P29/00A61P25/06A61P25/00A61P1/02A61P15/00A61P21/00A61P19/02
Inventor 杨立新祁静杨洋陈东贾毓宁
Owner BEIJING JIACHENG MEDICINE