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Quaternized halamine modified graphene oxide antibacterial nanoparticles and preparation method thereof

A technology of antibacterial nano-particles and oxidized rocks, applied in the direction of botany equipment and methods, nanotechnology, nanotechnology, etc., can solve the problems that need to be improved, such as single antibacterial activity, and achieve good bactericidal effect and environment-friendly effect

Active Publication Date: 2021-06-18
CHANGCHUN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After continuous research, although graphene oxide shows high antibacterial activity among graphene-based materials, its single antibacterial activity still needs to be improved.

Method used

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  • Quaternized halamine modified graphene oxide antibacterial nanoparticles and preparation method thereof
  • Quaternized halamine modified graphene oxide antibacterial nanoparticles and preparation method thereof
  • Quaternized halamine modified graphene oxide antibacterial nanoparticles and preparation method thereof

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preparation example Construction

[0027] The present invention firstly provides a kind of preparation method of quaternized ammonium haloamine modified graphene oxide antibacterial nanoparticles, such as figure 1 As shown, the method includes:

[0028] Step 1: Prepare 3-bromopropyl-5,5-dimethylhydantoin with 1,3 dibromopropane, anhydrous potassium carbonate, and 5,5 dimethylhydantoin; the preparation process is preferably:

[0029] Weigh 5,5 dimethylhydantoin and dissolve it in solvent acetone, then add anhydrous K 2 CO 3 , condensed and refluxed at 60-70°C for 1-3 hours, then gradually added 1,3-dibromopropane, continued to reflux for 10-12 hours, filtered to remove unreacted potassium carbonate, collected the filtrate and distilled under reduced pressure to obtain a white solid crude product ; The obtained white crude product was separated with water and dichloromethane, and the organic phase was retained. After dehydration with anhydrous magnesium sulfate, the filtrate was collected and subjected to vacu...

Embodiment 1

[0040] (1) Weigh 3.2g of 5,5 dimethylhydantoin and dissolve it in 120ml of acetone, then add 10g of anhydrous K 2 CO 3 , condensed and refluxed at 70°C for 1 hour, then gradually added 2.8ml 1,3-dibromopropane, continued to reflux for 12h, filtered to remove unreacted potassium carbonate, collected the filtrate and distilled under reduced pressure to obtain a white solid crude product; The white crude product was partitioned with water and dichloromethane, and the organic phase was retained. After dehydration with anhydrous magnesium sulfate, the filtrate was collected and subjected to vacuum distillation to obtain 3-bromopropyl-5,5-dimethylhydantoin.

[0041](2) Ultrasonicate 0.2g of graphene oxide and distilled water at room temperature for 15min, add 1.5mL of 4-vinylpyridine and 0.27g of potassium persulfate to react at 65°C for 2 hours, cool the mixture to room temperature, wash with distilled water and N, N-dimethylformamide was washed alternately by centrifugation. 4-...

Embodiment 2

[0043] (1) Weigh 3.2g of 5,5 dimethylhydantoin and dissolve it in 120ml of acetone, then add 10g of anhydrous K 2 CO 3 , condensed and refluxed at 70°C for 1 hour, then gradually added 2.8ml 1,3-dibromopropane, continued to reflux for 12h, filtered to remove unreacted potassium carbonate, collected the filtrate and distilled under reduced pressure to obtain a white solid crude product; The white crude product was partitioned with water and dichloromethane, and the organic phase was retained. After dehydration with anhydrous magnesium sulfate, the filtrate was collected and subjected to vacuum distillation to obtain 3-bromopropyl-5,5-dimethylhydantoin.

[0044] (2) 0.2g graphene oxide and distilled water were sonicated at room temperature for 15min, 1.5mL of 4-vinylpyridine and 0.27g potassium persulfate were added to react at 65°C for 2 hours, the mixture was cooled to room temperature, and distilled water and N,N-dimethylformamide was alternately centrifuged and washed. 4-...

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Abstract

The invention provides a preparation method of quaternized halamine modified graphene oxide antibacterial nanoparticles, and belongs to the technical field of antibacterial material synthesis. The method comprises the following steps: firstly, modifying 5,5-dimethylhydantoin by using 1,3-dibromopropane to prepare 3-bromopropyl-5,5-dimethylhydantoin for later use; then, grating 4-vinylpyridine on graphene oxide in situ; and finally, grafting 3-bromopropyl-5, 5-dimethylhydantoin to the modified graphene oxide, and carrying out chlorination with sodium hypochlorite, so as to obtain the quaternized N-halamine modified graphene oxide antibacterial nanoparticles. The quaternized halamine modified graphene oxide antibacterial nano material disclosed by the invention has an excellent antibacterial effect and can be recycled through a sterilization-chlorination-sterilization process. Meanwhile, contact sterilization and release sterilization functions are realized.

Description

technical field [0001] The invention belongs to the technical field of antibacterial material synthesis, and relates to a quaternized ammonium haloamine-modified graphene oxide antibacterial nanoparticle and a preparation method thereof. Background technique [0002] Microbial contamination and various bacterial diseases have been threatening human health and safety, placing a heavy burden on the global economy and public health activities. However, the antibacterial mechanism of an antibacterial agent is single, and highly effective antibacterial agents with rich bactericidal pathways are urgently needed. Combined use of multiple antibacterial drugs to obtain a stronger bactericidal effect has become an important way to prepare high-efficiency antibacterial materials. Graphene oxide has been widely used in many fields due to its unique physical and chemical properties. After continuous research, although graphene oxide shows high antibacterial activity among graphene-base...

Claims

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Application Information

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IPC IPC(8): A01N43/50C07D401/14A01P1/00B82Y30/00B82Y40/00C08F292/00C08F226/06C08F8/30C08F8/20
CPCA01N43/50C07D401/14B82Y30/00B82Y40/00C08F292/00C08F8/20C08F8/30C08F226/06Y02A50/30
Inventor 肖凌寒敖玉辉卜聃琳程春霞冯恒宇王瑞强张佳良
Owner CHANGCHUN UNIV OF TECH
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