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Eye repair composition as well as preparation method and application thereof

A composition and eye technology, applied in skin care preparations, pharmaceutical formulas, cosmetic preparations, etc., can solve problems such as safety considerations, side effects, and increased eye burden, so as to improve bags under the eyes, Effective in reducing puffiness around the eyes and dark circles

Pending Publication Date: 2021-06-18
COSMAX CHINA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current eye care products on the market mainly have the following defects: ①General products cannot be well absorbed by the skin, have limited effects, and cannot penetrate deep into the dermis to fundamentally improve eye health; ②Some products have single effects, or Moisturizing, or reducing eye bags, or diluting dark circles, or improving wrinkles, all effects cannot be taken into account, and there are few products that can improve eye problems in an all-round way; ③Although some products can achieve quick results, after a period of use, they are prone to side effects. Or bring new problems such as fat particles, which increases the burden on the eyes; ④ Some products have a long onset period and need to be used for a long time. After discontinuation, problems such as eye bags, dark circles, and wrinkles will rebound; Stimulation, allergies, etc. occur, and safety needs to be considered

Method used

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  • Eye repair composition as well as preparation method and application thereof
  • Eye repair composition as well as preparation method and application thereof
  • Eye repair composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0031] The preparation method of the whitening plant extract composition is as follows: (1) dry the required plant parts, crush them, weigh them according to the required number, and mix them evenly; (2) add 25-40 times the amount of deionized water to extract, extract The temperature is 75-95°C, the extraction time is 2-4h, the number of extractions is 2-3 times, and the extracts are combined; (3) Cool the extract obtained in step (2) to 30°C or below, and use a 100-200 mesh Filtrate with gauze, filter twice, collect the filtrate to obtain the first filtrate, and let the first filtrate stand naturally for 24 hours; (4) centrifuge the solution after step (3) standing for 0.5-1 hour, the rotating speed is 2000-10000rpm, and the aperture is 0.1 -1.0 μm filter membrane is filtered, and the filtrate is collected to obtain the secondary filtrate; (5) the secondary filtrate obtained in step (4) is concentrated under reduced pressure, added polyhydric alcohol, and mixed; (6) the obtai...

experiment example 1

[0038] Experimental Example 1: Cytotoxicity Test

[0039] MTT is a yellow powder chemical reagent widely used in the detection of cytotoxicity or cell proliferation. The detection principle is that succinate dehydrogenase in the mitochondria of living cells can reduce MTT to water-insoluble blue-purple crystalline formazan and deposit it. In cells, dead cells do not have this function. Dimethyl sulfoxide (DMSO) can dissolve formazan in cells, and the number of living cells can be judged according to the measured absorbance value. The specific experimental method is as follows:

[0040] 1×10 per well in a 96-well plate 4 Each 100 μL of DMEM medium containing 10% bovine serum and human immortalized epidermal cells (HaCaT) were inoculated at a density of 1 cell, and replaced with serum-free medium after 24 hours of cultivation; 12 and the eye repair composition prepared in Comparative Example 1-3 were treated and incubated for 24 hours; the culture medium was removed and treate...

experiment example 2

[0046] Experimental Example 2: Determination of Inhibition of Tyrosinase Activity

[0047] As shown in Table 3, add the phosphate buffer solution with a pH of 6.8, the eye repair composition prepared in Examples 1-12 and Comparative Examples 1-3, and the tyrosine solution to the test tube in sequence, and bathe in water at 35°C for 10 minutes. Then add tyrosinase solution, mix well, incubate at 35°C for 30 minutes, quickly transfer to a cuvette, and measure the absorbance value at 475nm. The experimental group, negative control, and positive control were adjusted to zero with blank control 1, blank control 2, and blank control 3, respectively.

[0048] The concentrations of the eye repair composition and the arbutin solution used in the experiment were both 1 mg / mL.

[0049] Tyrosinase inhibition rate=[(A-B) / A]×100%, A is the absorbance value of the negative control, B is the absorbance value of the experimental group or the positive control.

[0050] table 3

[0051]

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Abstract

The invention discloses an eye repair composition as well as a preparation method and application thereof. The eye repair composition is prepared from the following components in parts by weight: 0.001 to 0.02 part of acetyl tetrapeptide-5, 1 to 6 parts of a whitening plant extract composition and 1 to 6 parts of a mushroom mycelium extract. The prepared eye repair composition is matched with the peptides, the plant extract and the mushroom mycelium extract, and is easily absorbed by skin, the components can achieve synergistic interaction on the premise of fully playing respective roles, and the technical effects of quickly and efficiently fading dark eye circles, relieving eye edema, reducing eye bags and improving the elasticity of the skin around the eyes are achieved. The eye repair composition prepared by the invention is mild, non-irritant, safe and free of side effects, and the preparation method is simple and convenient.

Description

technical field [0001] The invention belongs to the technical field of daily cosmetics, and relates to an eye repair composition and its preparation method and application. Background technique [0002] Eyes are the focus of a person's attention, which can intuitively reflect a person's age and mental state, and are crucial to improving the external image, overall temperament and beauty. The eye skin is the thinnest skin in the human body, there are few sweat glands and sebaceous glands in the skin around the eyes, the lack of elastic fibers and collagen structure in the dermis, the distribution of nerve fibers and capillaries in the skin around the eyes is high, and the workload of the eyes is heavy, etc. , based on the characteristics of the eye skin itself and changes in modern lifestyles, such as pollution, light, stress, staying up late, unhealthy diet, smoking, etc., the eye skin is sensitive and fragile, easy to dry, accelerated aging, eye bags, dark circles, Wrinkle...

Claims

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Application Information

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IPC IPC(8): A61K8/9728A61K8/64A61K8/9789A61K8/9794A61Q19/00A61Q19/02A61Q19/08A61Q1/14
CPCA61K8/9728A61K8/64A61K8/9789A61K8/9794A61Q19/005A61Q1/14A61Q19/02A61Q19/08A61K2800/782A61K2800/85A61K2800/5922Y02A50/30
Inventor 施丽娟周秋娜金荣熙刘攀攀尹锺赫金延埈
Owner COSMAX CHINA INC
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