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Gamithromycin sustained-release preparation and preparation method thereof

A technology for gamimycin and sustained-release preparations, which is applied in the field of gaminomycin sustained-release preparations and its preparation, can solve the problems that ordinary preparations cannot maintain effective therapeutic concentrations for a long time, drug side effects, etc., and achieve large-scale industrialization Production, high drug loading, and high safety effects

Pending Publication Date: 2021-06-18
四川恒通动保生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In practical application, the rapid release of the drug will cause the blood concentration of the drug to exceed the therapeutic range and cause side effects. In addition, common preparations cannot maintain the effective therapeutic concentration for a long time, and it is necessary to develop new preparations that can maintain the effective therapeutic concentration for a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A garamiycin sustained-release preparation is prepared from the following raw materials in parts by weight:

[0022] Gamitomycin 5g, sodium carboxymethyl cellulose 10g and glucose 85g.

[0023] (1) Ultrafine pulverization: add gamitomycin to a pulverizer for ultrafine pulverization, and control the ultrafine pulverization particle size to be below 50 μm to obtain gamitomycin ultrafine powder for subsequent use;

[0024] (2) adding the slow-release matrix material to the water and stirring to obtain a coating liquid;

[0025] (3) put the garamiycin ultrafine powder into the multifunctional fluidized bed, use the coating solution obtained in step (2) to spray-coat the erythromycin thiocyanate raw material, after the coating finishes, continue Dry for 30min and discharge;

[0026] (4) After mixing the powder obtained after spray coating in step (3) with the auxiliary materials, press into tablets to obtain the garamiycin sustained-release preparation of the present inven...

Embodiment 2

[0028] A garamiycin sustained-release preparation is prepared from the following raw materials in parts by weight:

[0029] Gamitomycin 50g, Carrageenan 40g and Jiayi Powder 10g.

[0030] (1) Ultrafine pulverization: add gamitomycin to a pulverizer for ultrafine pulverization, and control the ultrafine pulverization particle size to be below 50 μm to obtain gamitomycin ultrafine powder for subsequent use;

[0031] (2) adding the slow-release matrix material to the water and stirring to obtain a coating liquid;

[0032] (3) put the garamiycin ultrafine powder into the multifunctional fluidized bed, use the coating solution obtained in step (2) to spray-coat the erythromycin thiocyanate raw material, after the coating finishes, continue Dry for 30min and discharge;

[0033] (4) After mixing the powder obtained after spray coating in step (3) with the auxiliary materials, press into tablets to obtain the garamiycin sustained-release preparation of the present invention.

Embodiment 3

[0035] A garamiycin sustained-release preparation is prepared from the following raw materials in parts by weight:

[0036] Gamitomycin 20g, xanthan gum 30g and maltodextrin 50g.

[0037] (1) Ultrafine pulverization: add gamitomycin to a pulverizer for ultrafine pulverization, and control the ultrafine pulverization particle size to be below 50 μm to obtain gamitomycin ultrafine powder for subsequent use;

[0038] (2) adding the slow-release matrix material to the ethanol and stirring to obtain a coating liquid;

[0039] (3) put the garamiycin ultrafine powder into the multifunctional fluidized bed, use the coating solution obtained in step (2) to spray-coat the erythromycin thiocyanate raw material, after the coating finishes, continue Dry for 30min and discharge;

[0040] (4) After mixing the powder obtained after spray coating in step (3) with the auxiliary materials, press into tablets to obtain the garamiycin sustained-release preparation of the present invention.

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Abstract

The invention discloses a gamithromycin sustained-release preparation and a preparation method thereof. The gamithromycin sustained-release preparation comprises the following components in parts by weight: 5-50 parts of gamithromycin, 10-40 parts of a sustained-release framework material and 10-85 parts of auxiliary materials, the sustained-release framework material is prepared from xanthan gum, sodium carboxymethyl cellulose and carrageenan according to the mass ratio of 1: 1: 1, and the auxiliary material is prepared from soluble starch and Jiyi powder according to the mass ratio of 2: 1. The gamithromycin sustained-release preparation prepared by the invention is convenient to take, good in compliance, good in sustained-release effect, good in stability, high in drug loading capacity and high in safety; and the preparation process is convenient and rapid, and is beneficial to industrial large-scale production.

Description

technical field [0001] The invention relates to the technical field of veterinary antibiotics, in particular to a gamitomycin sustained-release preparation and a preparation method thereof. Background technique [0002] Gamimycin is a new type of semi-synthetic azalide with a 15-membered ring for animals. It mainly binds to the 50S subunit of the bacterial ribosome to prevent the elongation of the polypeptide chain and inhibit the synthesis of bacterial proteins. Gamycin acts in a bacteriostatic manner against Mannella bovis, Pasteurella multocida, Actinobacillus pleuropneumoniae, Pasteurella multocida and Haemophilus parasuis. The 7a-position of the ester ring is an alkylated nitrogen, which can be rapidly absorbed under physiological pH conditions and maintain a long-term effect in the lung tissue of target animals. For the treatment of respiratory diseases (SRD, BRD) in pigs and cattle, foot lesions and lameness in sheep. It has the advantages of fast absorption, fast o...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K47/38A61K47/36A61K31/7052A61P31/04
CPCA61K9/205A61K9/2054A61K31/7052A61P31/04
Inventor 刘起军吴成剑马亚罗敏
Owner 四川恒通动保生物科技有限公司
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