Gamithromycin sustained-release preparation and preparation method thereof

Abstract

The invention discloses a gamithromycin sustained-release preparation and a preparation method thereof. The gamithromycin sustained-release preparation comprises the following components in parts by weight: 5-50 parts of gamithromycin, 10-40 parts of a sustained-release framework material and 10-85 parts of auxiliary materials, the sustained-release framework material is prepared from xanthan gum, sodium carboxymethyl cellulose and carrageenan according to the mass ratio of 1: 1: 1, and the auxiliary material is prepared from soluble starch and Jiyi powder according to the mass ratio of 2: 1. The gamithromycin sustained-release preparation prepared by the invention is convenient to take, good in compliance, good in sustained-release effect, good in stability, high in drug loading capacity and high in safety; and the preparation process is convenient and rapid, and is beneficial to industrial large-scale production.

Description

technical field

[0001] The invention relates to the technical field of veterinary antibiotics, in particular to a gamitomycin sustained-release preparation and a preparation method thereof. Background technique

[0002] Gamimycin is a new type of semi-synthetic azalide with a 15-membered ring for animals. It mainly binds to the 50S subunit of the bacterial ribosome to prevent the elongation of the polypeptide chain and inhibit the synthesis of bacterial proteins. Gamycin acts in a bacteriostatic manner against Mannella bovis, Pasteurella multocida, Actinobacillus pleuropneumoniae, Pasteurella multocida and Haemophilus parasuis. The 7a-position of the ester ring is an alkylated nitrogen, which can be rapidly absorbed under physiological pH conditions and maintain a long-term effect in the lung tissue of target animals. For the treatment of respiratory diseases (SRD, BRD) in pigs and cattle, foot lesions and lameness in sheep. It has the advantages of fast absorption, fast o...