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Metformin hydrochloride sustained release tablet composition

A technology of metformin hydrochloride and sustained-release tablets, which is applied in the directions of drug combinations, medical preparations of inactive ingredients, coatings, etc. Problems such as poor physical properties of the coating film, to achieve the effect of overcoming easy rupture

Active Publication Date: 2021-06-18
DISHA PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the acrylic resin Kollicoat SR30D coating material, the coating film formed by ethyl cellulose has poor physical properties, is easy to break, and has low ductility and compression resistance. Slow and controlled release performance
This further limits the development of ethyl cellulose sustained-release pellets coating tablet technology
Some researchers increase the weight of the coating, that is, increase the thickness of the coating film to overcome the problem of not being able to withstand pressure, but the effect is poor

Method used

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  • Metformin hydrochloride sustained release tablet composition
  • Metformin hydrochloride sustained release tablet composition
  • Metformin hydrochloride sustained release tablet composition

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0035] Experimental example 1. Prescription:

[0036] .

[0037] Prepare 1000 tablets according to the preparation method described in the prescription dosage and the technical scheme of the instructions.

Embodiment 2

[0038] Embodiment 2. Prescription:

[0039] .

[0040] Prepare 1000 tablets according to the preparation method described in the dosage of the prescription and the technical scheme of the instruction manual.

Embodiment 3

[0041] Embodiment 3. Prescription:

[0042] .

[0043] Prepare 1000 tablets according to the preparation method described in the prescription dosage and the technical scheme of the instructions.

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PUM

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Abstract

The invention relates to a metformin multi-unit sustained release tablet composition, and belongs to the technical field of pharmaceutical preparations. The metformin hydrochloride multi-unit sustained release tablet composition comprises a plain pill core, a coating layer and a filling agent, and is specifically characterized in that the plain pill core contains 50.0 parts of metformin hydrochloride, 13.2 parts of D-trehalose and 0.8 part of hydroxypropyl cellulose LF, the coating layer contains 19.0-21.0 parts of D-trehalose, 4.2-6.2 parts of ethyl cellulose (Surelease®174) and 0.8 part of magnesium stearate, and the filling agent contains 10.0 parts of microcrystalline cellulose, and the part is mass percent. The metformin hydrochloride multi-unit sustained release tablet meeting clinical requirements is provided.

Description

technical field [0001] The invention relates to a metformin multi-unit sustained-release tablet composition, belonging to the technical field of pharmaceutical preparations. Background technique [0002] There are two final dosage forms of multi-unit preparations: one is to pack dispersed units into ordinary hollow capsules to form capsules; the other is to compress them into tablets. Pellets and tablets can be divided when taken, and clinical medication is more flexible, which has become a research hotspot. Tablets prepared from metformin hydrochloride sustained-release pellets are not currently on the market. The main technical obstacles are: ①The pellet coating is easy to be damaged during tablet compression, resulting in inconsistent drug release curves before and after tablet compression; The small and medium pellets collide and fuse with each other, and cannot quickly disintegrate into a single pellet in the gastrointestinal tract after taking it. Lead to inconsiste...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K47/36A61K47/38A61K31/155A61P3/10
CPCA61K9/205A61K9/2054A61K9/2095A61K9/2077A61K9/286A61K9/2866A61K31/155A61P3/10
Inventor 王成王江涛张友凯杨德斌
Owner DISHA PHARMA GRP
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