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Visual fucoidin embolization microsphere and preparation method thereof

A fucoidan and microsphere technology, which is applied in the field of visualized fucoidan embolization microspheres and its preparation, can solve the problems of small selectivity, few types, and high technical threshold, and achieves high-efficiency drug loading and is conducive to large-scale production. Effect

Active Publication Date: 2021-06-18
苏州微尺度科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since the embolic agents currently used clinically do not have imaging functions, it is impossible to evaluate the embolization effect. In addition, the technical threshold of embolic microsphere products is high, there are few categories, and the options are small, making the price high and greatly increasing the medical treatment of patients. cost

Method used

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  • Visual fucoidin embolization microsphere and preparation method thereof
  • Visual fucoidin embolization microsphere and preparation method thereof
  • Visual fucoidin embolization microsphere and preparation method thereof

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preparation example Construction

[0063] In this method, microspheres are carried out primarily, and polymerization reactions are achieved in this process. Specifically, the method mainly includes three steps, and decibel is: (1) preparation of the macromolysaccharide molar of unsaturated bond; (2) formation of membrane emulsification, continuous phase; (3) The dispersion phase and the continuous phase reaction obtain the embolization microspheres. Obviously, in the foregoing steps, two steps (1) and step (2) can be performed simultaneously, or other sequential performed, and is not implemented in the order described above. In other words, the preparation method proposed in the present application is a backup step, and the step of polymerizing the polymerization using the prepared material to form a plug microsphere.

[0064] Among them, the preparation method of the unsaturated bonded fucose polysaccharide macromolecule is as follows:

[0065] The first solution was obtained in a basic solution in an amount of fr...

Embodiment 1

[0086] Preparation of visualized carine polysaccharols microspheres, including the following steps:

[0087] Step 1: Preparation of functionalized carine polysaccharide mons:

[0088] 50 g of a 50 mLPH = 8.0 was dissolved in aqueous solution of 150 mLPH = 8.0, and a 20% aqueous polysaccharide solution was disposed in a mass concentration; then 10 ml of acrylic acid and 0.2 g of carboxy-modified tetrasoxide three iron nanoparticles were added to the system. The above-mentioned system temperature was raised to 65 ° C, 400 rpm was stirred for 10 h, i.e., the unsaturated bond and the tetraned iron-modified fucose polysaccharide; finally used ethanol as a precipitant, was reversed, washed, and vacuum dried to functionify Magnetic fucodaine intermediate.

[0089] Step 2: Formulation of membrane emulsification method:

[0090] Take 10G steps to dissolve the unsaturated bond in step one in 30 ml of water, stirred at 70 ° C, stirred evenly, 300 rpm is mixed, resulting in a 20% polysacchari...

Embodiment 2

[0096] Preparation of visualized carine polysaccharols microspheres, including the following steps:

[0097] Step 1: Preparation of functionalized carine polysaccharide mons:

[0098] 50 g of fucose solid was dissolved in 150 mL of pH = 8.0, a sodium carbonate water solution was configured to 25% aqueous polysaccharide solution of mass concentration; then 10 ml of acrylic acid and 0.6 g of carboxy-modified tetraned iron was added to the system. Nanoparticles.

[0099] The above-mentioned system temperature was raised to 65 ° C, 400 rpm. The mixture was stirred for 10 h, i.e., the aqueous unsaturated bonded fucosaccharide aqueous solution; finally used ethanol as a precipitant, was reversed, washed, vacuum dried to obtain a functionalized magnetic calamine. Polysaccharide intermediate.

[0100] Step 2: Formulation of membrane emulsification method

[0101] Take 10G steps to dissolve the unsaturated bond in step one in 30 ml of water, stirred at 70 ° C, stirred evenly, 300 rpm is mi...

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Abstract

The invention relates to a visual fucoidin embolization microsphere and a preparation method thereof, and belongs to the field of embolization microspheres. The embolization microsphere adopts fucoidin as a main component, and the fucoidin is functionally modified, so that the embolization microsphere has a magnetic resonance imaging function. The embolization agent is low in cost and can replace existing expensive embolization microsphere products at home and abroad.

Description

Technical field [0001] The present application relates to the field of embolism microspheres, and in particular, there is a visualized frank alginate microsphere and a preparation method thereof. Background technique [0002] TRANSCATETER ARIAL CHEMOEMBOLIZATION, referred to as TACE has gradually become preferred for the treatment of non-surgical resection tumors. The principle is that the doctor is injected into the blood vessel of the lesion to the lesion of the lesion, reaches the diseased stove blood vessels to cut the neoplastic supply of the lesion, so that the tumor is shrunk, necrosis, and finally achieve treatment. [0003] As the key to success or failure in TACE, the choice of embolism is critical. [0004] Since the current clinical embolism itself does not have imaging function, the embolus effect is not evaluated, in addition, the technological threshold of embolization microspheres is high, less type, can be selectively small, so that the price is high, greatly inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/04A61L24/00A61K49/12
CPCA61L24/08A61L24/046A61L24/0015A61L24/001A61L24/0036A61K49/126A61L2300/418A61L2300/416A61L2300/602A61L2300/232A61L2400/06C08L5/00
Inventor 党萌
Owner 苏州微尺度科技有限公司
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