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Biliary stent surface nano-coating and preparation method thereof

A nano-coating, bile duct technology, applied in coating, metal material coating process, surgery, etc., can solve problems such as health toxicity and side effects

Active Publication Date: 2021-06-18
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, silver is not an essential trace element for the human body, and the biliary stent coating made of pure silver has potential toxic and side effects on human health

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A preparation method for a nano-coating on the surface of a biliary stent, comprising the following steps:

[0020] The metal material is used as the support substrate, and the substrate is pretreated. The pretreatment includes pickling, degreasing, grinding, cleaning and drying. The pickling solution is 15% HCl solution, and the grinding is respectively 400# and 600# , 800# and 1200# sandpaper, 15% sodium carbonate solution is used for degreasing, deionized water is used for cleaning with ultrasonic auxiliary cleaning, and drying is carried out under a protective atmosphere.

[0021] Put the dried substrate into the magnetron sputtering coater, use the Ag-25at%Co composite target as the sputtering source, and use argon as the working gas to deposit the Ag-Co coating on the surface of the substrate by sputtering . When sputtering coating, the background vacuum is 5×10 -5 Pa, the argon gas flow rate is 80 sccm, the substrate temperature is 120°C, the sputtering pressur...

Embodiment 2

[0024] A preparation method for a nano-coating on the surface of a biliary stent, comprising the following steps:

[0025] The metal material is used as the support substrate, and the substrate is pretreated. The pretreatment includes pickling, degreasing, grinding, cleaning and drying. The pickling solution is 15% HCl solution, and the grinding is respectively 400# and 600# , 800# and 1200# sandpaper, 15% sodium carbonate solution is used for degreasing, deionized water is used for cleaning with ultrasonic auxiliary cleaning, and drying is carried out under a protective atmosphere.

[0026] Put the dried substrate into the magnetron sputtering coating machine, use the Ag-29at%Co composite target as the sputtering source, and use argon as the working gas to deposit the Ag-Co coating on the surface of the substrate by sputtering . When sputtering coating, the background vacuum is 5×10 -5 Pa, the argon gas flow rate is 80 sccm, the substrate temperature is 120°C, the sputterin...

Embodiment 3

[0029] A preparation method for a nano-coating on the surface of a biliary stent, comprising the following steps:

[0030] The metal material is used as the support substrate, and the substrate is pretreated. The pretreatment includes pickling, degreasing, grinding, cleaning and drying. The pickling solution is 15% HCl solution, and the grinding is respectively 400# and 600# , 800# and 1200# sandpaper, 15% sodium carbonate solution is used for degreasing, deionized water is used for cleaning with ultrasonic auxiliary cleaning, and drying is carried out under a protective atmosphere.

[0031] Put the dried substrate into the magnetron sputtering coating machine, use the Ag-35at%Co composite target as the sputtering source, and use argon as the working gas to deposit the Ag-Co coating on the surface of the substrate by sputtering . When sputtering coating, the background vacuum is 5×10 -5 Pa, the argon gas flow rate is 80 sccm, the substrate temperature is 120°C, the sputterin...

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PUM

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Abstract

The invention relates to a biliary stent surface nano-coating and a preparation method thereof. In order to overcome the toxic and side effects of a biliary stent surface nano-silver coating, metal element silver is replaced by part of metal element cobalt, and the safety of a biliary stent coating material is greatly improved at the cost of sacrificing the antibacterial property of part of the coating. Researches show that when the cobalt content in the coating is 29%, the antibacterial performance and toxic and side effects of the stent coating achieve the most excellent balance effect.

Description

technical field [0001] The invention relates to the field of nano coatings, in particular to a nano coating on the surface of a biliary stent and a preparation method thereof. Background technique [0002] The biliary system has the functions of secreting, storing, concentrating and transporting bile, and plays an important role in regulating the discharge of bile into the duodenum. However, malignant tumors such as biliary tract cancer, liver cancer, pancreatic cancer and metastatic cancer may cause biliary obstruction. The best way to relieve biliary obstruction is to place a biliary stent so that bile can flow to the intestinal lumen through the stent. In order to enhance the drainage effect, stents of various types and materials have been continuously improved, and various materials such as plastic stents, metal stents, drug-acquired stents with radioactive particles, and biodegradable stents have emerged as the times require. [0003] In clinical practice, it has been ...

Claims

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Application Information

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IPC IPC(8): A61L31/08A61L31/14A61L31/16C23C14/35C23C14/16C23C14/20C23C14/58C22C5/06
CPCA61L31/088A61L31/14A61L31/16A61L2300/102A61L2300/104A61L2300/404A61L2300/45A61L2300/606C22C5/06C23C14/165C23C14/205C23C14/35C23C14/5886
Inventor 肖瑶姚磊翟登高孙慧黄敏欧阳锡武
Owner XIANGYA HOSPITAL CENT SOUTH UNIV