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Application of niobium carbide nano-material and cell culture medium for promoting cell proliferation

A technology of cell proliferation and nanomaterials, applied in the cell culture medium that promotes cell proliferation, the application field of niobium carbide nanomaterials, can solve the problems of limited influence of biofilm and no promotion of cell proliferation, etc. Effects of normal tissue damage

Pending Publication Date: 2021-06-18
上海简巨医学生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] So far, these have been designed primarily to inhibit bacterial adhesion, with limited impact on established biofilms
In addition, due to the long-term use of traditional antimicrobial ions such as silver, silver-resistant bacteria have been reported, which warns that traditional treatment regimens may induce drug resistance
Moreover, traditional antibacterial ions such as silver generally have no promoting effect on cell proliferation.

Method used

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  • Application of niobium carbide nano-material and cell culture medium for promoting cell proliferation
  • Application of niobium carbide nano-material and cell culture medium for promoting cell proliferation
  • Application of niobium carbide nano-material and cell culture medium for promoting cell proliferation

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Embodiment 1

[0023] This embodiment provides a cell culture medium for promoting cell proliferation, which is obtained by mixing endothelial cell culture medium (ECM basal medium) without serum, double antibody and growth factor and niobium carbide nanomaterials, wherein niobium carbide The mass content of the nanomaterial is 1%, and the particle size of the niobium carbide nanomaterial is 17nm.

Embodiment 2

[0025] This embodiment provides a cell culture medium for promoting cell proliferation, which is obtained by mixing endothelial cell culture medium (ECM basal medium) without serum, double antibody and growth factor and niobium carbide nanomaterials, wherein niobium carbide The mass content of the nanometer material is 0.1%, and the particle size of the niobium carbide nanomaterial is 90nm.

Embodiment 3

[0027] This embodiment provides a cell culture medium for promoting cell proliferation, which is obtained by mixing endothelial cell culture medium (ECM basal medium) without serum, double antibody and growth factor and niobium carbide nanomaterials, wherein niobium carbide The mass content of the nanomaterial is 2%, and the particle size of the niobium carbide nanomaterial is 10nm.

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Abstract

The invention is applicable to the technical field of biomedical materials, and provides application of a niobium carbide nano-material and a cell culture medium for promoting cell proliferation, the cell culture medium for promoting cell proliferation comprises a basic culture medium and the niobium carbide nano-material, and also can comprise additives such as albumin and / or cell growth factors, wherein the concentration of the niobium carbide nano-material is 1-100 [mu] g / mL. According to the embodiment of the invention, the niobium carbide nano-material is added into the cell culture medium, which can remarkably up-regulate the expression of cell growth factors such as vascular endothelial growth factors, promote the proliferation and migration of vascular endothelial cells, and remarkably promote angiogenesis and wound healing.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to the application of a niobium carbide nanometer material and a cell culture medium for promoting cell proliferation. Background technique [0002] Cell culture medium is one of the key raw materials for biopharmaceutical production. It artificially simulates the nutritional environment in which cells grow in the body, provides cell nutrition and promotes the material basis for cell growth and proliferation, and can be widely used in biopharmaceutical industries such as vaccines and monoclonal antibodies, as well as various biomedical technology research. [0003] In the 21st century, medical implants have been widely used, and bacterial infection caused by medical implants has become an important clinical problem to be solved. Clinical medical studies have shown that invading bacteria tend to rapidly adhere to bioactive implant surfaces and form biofilms ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/071
CPCC12N5/069C12N2500/20C12N2501/998C12N2501/165
Inventor 周海铃陈怀俊
Owner 上海简巨医学生物工程有限公司